One of the popular antimicrobial drugs prescribed by doctors for a wide range of diseases is a drug presented in pharmacies under the name Augmentin. Instructions for use (tablets, suspension, powder - release form) contain clear instructions regarding the frequency of administration and characteristics of therapy with this medication. It is important to observe all these provisions so that treatment does not become a source of side effects and worsening of the patient's situation.
general information
As can be seen from the instructions, "Augmentin" (suspension, tablets) is an antimicrobial medication based on amoxicillin. This antibiotic is half synthetic in origin and is highly effective. Numerous studies have shown a high level of effectiveness of the drug when infected with microscopic life forms: gram-positive, gram-negative.
The specificity of the application described in the instructions for use "Augmentin" (875, 125 - any form) is based on the possibility of beta-lactamase effect on the active compound. Therefore, the drug will not show effectiveness if the patient is infected with bacteria that can produce this particular enzyme compound.
Professional approach
As part of the studies, it was found that clavulanic acid, which is inherently close to penicillin compounds, is capable of blocking the activity of beta-lactamase. Its activity extends to a fairly wide range of beta-lactamases. This is especially important in the treatment of patients infected with cephalosporins, penicillins. Information about the characteristics of clavulanic acid formed the basis of modern development - the drug "Augmentin." The instruction (125, 875 - of any form) clearly explains what features the pharmacological effect of the drug helps to cope with infection.
Clavulanic acid, as certified tests have shown, is resistant to plasmid beta-lactamases, due to which many bacteria get their resistance. The effectiveness of the use of the compound is slightly less pronounced if beta-lactamases belong to the first type of chromosome. The compound practically does not stop their activity. As can be seen from the instructions for the use of Augmentin (125, 875), it is thanks to the presence of such an acid that the main component receives protection from enzymatic destruction, which makes the drug as a whole applicable to a wider range of pathologies.
Pharmacy Assortment
A rather wide variety of items are on sale, so the final decision should remain with the attending doctor, who is able to determine exactly which drug is suitable in this case. Of course, it will not be superfluous to study the Augmentin instructions (875, 125 and other forms) before using it in accordance with medical recommendations, but it is categorically unreasonable to use such a tool, focusing only on information from the manufacturer. It is unacceptable to prescribe any antimicrobial formulations on your own, this applies to Augmentin, despite the prevailing opinion of its safety for humans.
One popular form is tablets containing half a gram of antibiotic and 125 mg of clavulanic acid. The cardboard box contains information on the dosage of two main substances, the number of tablets in the package (usually 14 pieces). To increase efficiency, simplify digestibility, the drug is supplemented with special compounds. All of them are listed in detail in the instructions for tablets Augmentin. A careful study of the instructions is especially important for people suffering from allergic reactions to components used in the pharmaceutical industry. If you are hypersensitive to any substance, you should warn your doctor about this.
Release Forms
In addition to the mentioned tablets, other options are also presented, for example, Augmentin 875 + 125. The instructions for use of this medication contain a decoding of digital values: 125 - the amount (in mg) of acid, 875 mg - the volume of the antibiotic. The product is available in tablets and supplemented with some specific substances that simplify the administration.
For the use of an antimicrobial preparation in the form of injections, two types of powder can be found on sale: 500 + 100 and twice as much concentration. As can be seen from the instructions for use, Augmentin for children is recommended in the form of a suspension. In this format, the tool is represented by a 70 ml bottle. 200 mg of amoxicillin accounts for 28.5 mg of clavulanic acid. To simplify the intake and increase the efficiency, digestibility of the composition, additional components have been introduced, including means to give a pleasant aroma.
Use correctly
As can be seen from the instructions, "Augmentin" is not intended for simultaneous use with preparations containing probenecid - this compound can lower the rate of secretion of the antimicrobial compound. “Augmentin”, combined with probenecid, can cause an increased concentration of amoxicillin in the patient's circulatory system (plasma). Sometimes this effect persists for an unacceptably long time. Studies have shown that probenecid does not affect the amount of clavulanic acid.
The use of amoxicillin and allopurinol is associated with an increased risk of an allergic reaction that manifests itself on the skin. The instructions of Augmentin do not clarify this risk, since there is no official information about the possibility of the mutual influence of the compounds on the patient while taking it.
Accuracy will not hurt
The described drug is recommended for the treatment of adults and children. “Augmentin” (the instruction confirms this) is a relatively safe means, however, certain side effects and a specific effect on the human body are characteristic of it, as well as any other representatives of the antimicrobial medication group. It is known that the tool can negatively affect the intestinal microflora. Under the influence of the active compound, estrogen reabsorption decreases. If the patient uses oral combined contraceptives, when using an antimicrobial agent, their effectiveness may decrease.
As can be seen from the instructions "Augmentin" (tablets 875 + 125 and other forms), due to the acid in the composition of the medication there is a chance of a connection on the red blood cell membranes of albumin, IgG. When conducting a Coombs study, the results may be positive, but this information will be false. If such a study is prescribed, but the patient is undergoing therapy using Augmentin, it is imperative to inform the doctor.
Sometimes you can’t
As can be seen from the instructions, "Augmentin" in the form of a solution for injection is not intended for simultaneous use with the introduction of blood preparations. The tool can not be used if it is necessary to enter a protein-rich liquid. The solution is not intended for the simultaneous administration of a patient with fatty emulsions into the body.
Additionally, the Augmentin instruction contains clarifications regarding the possibility of using the composition and aminoglycosides. The manufacturer focuses on the impossibility of mixing these components in containers, syringes. This may cause aminoglycoside to lose effectiveness. In addition, the tool is categorically not combined with alcohol.
Too much
The instructions for the use of Augmentin tablets (125, 875 - any form) contain mention of the possibility of using too much of the drug. In such a situation, the digestive system is the first to react, and the wrong water-electrolyte balance is observed. To eliminate the consequences of an overdose, it is necessary to take drugs in accordance with individual symptoms. There are known cases of crystalluria, sometimes provoking a failure of renal activity, but such situations are extremely rare.
Excessive dosage can lead to malfunctioning of the urinary catheter. To prevent unpleasant consequences, if necessary, the appointment of a high dose of the patient's antibiotic is put under control, regularly checking the patency of the organs. As mentioned in the instructions for use, "Augmentin" (tablets 875, 125, solution, suspension) after ingestion leads to the appearance of the active component in the circulatory system. If necessary, urgent cleaning of the body requires hemodialysis.
Features of the reception
About how to use Augmentin tablets, the instruction (875, 125 - any dosage) contains detailed and clear instructions. Prescribing an antibiotic, the doctor will give additional recommendations for the correct reception, taking into account the characteristics of the patient's condition. Normally, a tablet form of 625 mg is intended for the treatment of mild diseases, moderate forms. The drug is suitable for twelve year old patients and older. The drug is taken twice a day, one tablet.
If the disease is severe, infection of the bronchi, lungs, urinary tract is diagnosed, the infection is chronic, relapses are observed, you should take the drug three times daily in one or two capsules (the doctor will determine the specific dosage). As indicated in the instructions, Augmentin tablets (125 mg of clavulanic acid as part of the medication) are used daily in pieces twice a day if a dentoalveolar abscess is diagnosed. The duration of the therapeutic program is no more than five days.
Special occasion
As can be seen from the instructions, Augmentin (875 + 125 and in other forms) requires a special selection of the dose if the patient suffers from renal dysfunction. If this is observed in a mild form, the clearance exceeds 30 ml per minute, then a standard volume can be used. With an average level of severity, Augmentin is used daily one tablet twice. Severe form requires dose adjustment: up to one tablet daily (sometimes less if the doctor sees reasons for this).
Hemodialysis also requires adjustment of possible doses. Normally, one tablet is prescribed daily, as well as an additional dose of the drug during hemodialysis and as the procedure is completed. This is due to a decrease in the concentration of the active compound in the blood plasma of the patient.
Liver disease
In such a situation, as can be seen from the instructions for use, Augmentin should be used very carefully, constantly monitoring vital signs of the body, and liver functioning parameters. At present, a sufficiently complete information base has not been accumulated to determine specific doses for different conditions of patients.
If the course is an elderly patient, this does not require dose adjustment, but much depends on the quality of the kidneys.
Use correctly
Instructions for use "Augmentin" contains recommendations for the proper use of the medication. In particular, the tool should be used at the beginning of the meal - this helps to reduce the negative effect on the digestive tract, improves the quality of absorption of the active component in the circulatory system. The duration of the therapeutic course cannot be more than two weeks, unless a special assessment of the patient's condition is carried out. Combination of various antibiotic administration options is allowed. For example, the practice of first injecting is quite widespread, after which they gradually switch to the tablet form.
Augmentin 875 + 125: application features
Such a drug is on sale in tablets. The choice of dose remains at the discretion of the attending physician, evaluating both the characteristics of the disease and the specific parameters of the patient: age, weight, functionality of the renal system, pathology, severity of the disease. If the disease is defined as a lung of medium level, the optimal dosage for patients whose age is 12 years or older is one tablet twice a day. If the disease is severe, relapse is observed, a chronic course is established, the lungs, bronchi, and urine excretion pathways are affected, a tablet should be taken three times daily. But for patients under the age of twelve, Augmentin gram tablets should not be used.
If the patient has kidney failure, severe restrictions are placed on the possibility of using the drug. With clearance not reaching 30 ml per minute, the antibiotic is strictly prohibited. If the inferiority of the functioning of the liver is detected, the remedy is used, but the instructions for the use of "Augmentin" contain an unambiguous indication of the need for constant monitoring of the liver. Currently, there is insufficient clinical information to identify which dosages of the antimicrobial agent are optimal for which impaired hepatic function.
Suspension: how to use?
As can be seen from the instructions for use, “Augmentin” in this form for a disease in a mild or intermediate level should be consumed in an amount of 25 mg per day. Such therapy is optimal for infection of ENT organs. For a more serious disease, the dosage should be increased to 45 mg per one day of treatment. This is relevant for the detection of pneumonia that affects the bronchi, infection of the urinary organs.
Particular care requires dosage selection for the treatment of children. As can be seen from the instructions for use, Augmentin in the form of a suspension is suitable for the treatment of babies two years of age and older. The initial dose is 25 mg per day if the weight varies between 13-21 kg. From the age of seven years and older (with a weight of 22-40 kg), Augmentin can be used twice a day for 5 ml. The maximum dosage is 10 ml of suspension per day. It is very important to choose a specific option, after consulting with a doctor. The doctor will take the necessary tests, fully examine the child and select not only an effective, but also a safe option, coupled with minimal side effects.
Quite kids
Instructions for the use of Augmentin in the form of a suspension allows the use of the composition for the treatment of very young patients - already from two months of age. Dosage should be determined based on the weight of the patient. Currently, there is no official information about the consequences of using an antibiotic for treating infants younger than two months of age, respectively, there are no official recommendations regarding dose selection. If the doctor decides in favor of such a remedy, one should use the instructions for Augmentin in other forms. Without the help of a qualified specialist, using this method of treating a baby is categorically unacceptable.
Suspension: how to drink?
The rules and sequence of dilution are clearly described in the instructions for use of "Augmentin". On sale, the drug is presented in powder intended for mixing with water. In a special bottle (the product is in it), boiled water is poured strictly to the level indicated on the container, and then carefully closed with a lid. The bottle is shaken until a uniform suspension is formed. The mixture is allowed to infuse within five minutes, waiting for dispersion.
The next step of application is the introduction of an additional amount of water to the second level, also marked on the package. After that, the container is closed and shaken easily. The finished product has a white, slightly grayish tint (sometimes yellow). The finished medication is intended for storage at a temperature of two to eight degrees Celsius. The best place is the fridge. Shelf life is seven days. If the patient is two years old or younger, you can use syrup half diluted with boiled clean water. In general, as many users have noted, the instructions for using the Augmentin suspension are quite understandable, and it’s easy to follow.
Not at all
It is forbidden to use the drug in any form if a person has previously had jaundice or has suffered hepatic functional impairment while using Augmentin. Also, the drug can not be used if an increased susceptibility of beta-lactamase, cephalosporin, penicillin is detected.
Accuracy is the key to success
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Features of the therapeutic course
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When to apply?
In the form of injections, Augmentin is used in the treatment of a wide range of diseases, including gonorrhea. The tool helps to eliminate the infection of the female reproductive system, to prevent complications caused by surgical measures. Augmentin is recommended for use if surgery is performed on the pelvic organs, intestines or stomach, neck, heart, kidneys. The tool will help prevent infection during surgical procedures in the area of ​​the head, bile ducts, when changing joint areas. The medication is designed for temporary treatment, allows you to cope with bacterial infection. Effective against a specific spectrum of microscopic life forms.
"Augmentin" is used for infectious lesions of the ENT organs, respiratory tract, including sinusitis, bronchitis, pneumonia, tonsillitis, otitis media. The drug is recommended for cystitis, pyelonephritis, if diagnosed with urethritis. Proper use can prevent a negative outcome in case of burns, bites, abscesses and other infectious lesions of soft tissue, skin, subcutaneous tissue. You can use Augmentin for osteomyelitis, infection of bone, articular tissue, sepsis of various nature and shape, as well as for dental abscesses.
What are we buying?
"Augmentin" in pharmacies currently costs about 130 rubles per package, although there are more expensive options. In the absence of funds, you can replace it with some analogues. The selection of a replacement should be agreed with your doctor to avoid problems. Most often resort to the names:
- Amoxiclav;
- "Liklav";
- "Flemoklav".
Judging by the reviews, “Verklav”, “Fibell”, “Arlet” have proven themselves well. All of the funds mentioned are based on the active ingredients similar to the preparation under consideration. Among those differing in composition, but close (on the basis of belonging to one pharmaceutical group), the names “Santaz”, “Ampioks”, “Oksamsar” should be noted. Sometimes doctors recommend stopping at the means, at the pharmacy counters presented under the names Ampisid, Sultasin, Oksampitsin.
Everything has its time
The instructions clearly spell out which period Augmentin can be stored without loss of beneficial qualities. For tablets containing the active compounds 875 + 250, the time period is up to two years, a year longer, you can store the release in which amoxicillin is present in the amount of half a gram. The powder, on the basis of which the liquid is prepared for injection into a vein, is stored for two years. The same amount of powder can be stored until opening the powder for suspension, but after dilution, the composition in the refrigerator will last only seven days.
Information for Mothers
Currently, there are no strict restrictions regarding the impossibility of resorting to Augmentin during the period of gestation or breastfeeding, but the manufacturer generally does not recommend using the drug in this position. In each specific case, you should consult your doctor who is able to adequately assess the risks associated with the therapeutic course and the possible benefits of its passage. Only a qualified doctor can finally determine how reasonable the use of Augmentin in a given situation is.
Responsible approach
If Augmentin has not been used before, it is recommended that you first undergo an examination to establish the presence of hypersensitivity to the components of the drug before starting treatment. In addition, special tests should be done to confirm that pathological bacteria are sensitive to amoxicillin. Based on the information received from the laboratory, the doctor determines in what mode and in what form the medication should be used, what possible side reactions may be and how the patient should behave and their appearance.
The minimum therapeutic course lasts five days, the maximum duration is two weeks, after which a thorough study of the body's indicators should be carried out to determine how the tool affected various functions, organs.