To date, the drug "Armadin" is increasingly found in modern medical practice. Instructions for use (injections - the form we are considering) of this tool are quite difficult to master, in connection with which many prefer to search for more accessible data.
Next, we will consider how this tool works, what its advantages and disadvantages are, and also how to use it correctly.
Pharmacodynamics
"Armadin" is a specialized inhibitor of free radical processes, it is a membrane protector. In the process of taking this drug, it has a nootropic, antihypoxic, stress-protective and anxiolytic effect, the drug also significantly increases the body's resistance to the influence of various damaging factors and pathological oxygen-dependent conditions.
The instructions for use (injections) for the Armadin preparation are noted by the fact that with it the blood supply to the brain and brain metabolism improve, platelet aggregation decreases, the rheological properties of the blood, as well as its microcirculation, improve. At the same time, doctors often supplement this list with the fact that the drug is prescribed due to the stabilization of the membrane structures of blood cells during hemolysis, while its administration also reduces endogenous intoxication and enzymatic toxemia in case of acute pancreatitis.
How does he work?
Describes in sufficient detail the mechanism of action of the Armadin drug, instructions for use (injections), contraindications and other points. The work of this tool is due to its membrane-protective and antioxidant effects. During administration, the activity of superoxide dismutase increases, lipid peroxidation is inhibited, the lipid-protein ratio increases, and the viscosity of the membrane decreases, therefore, its fluidity increases. Among other things, taking this drug allows you to modulate the activity of various membrane-bound enzymes and receptor complexes, which positively affects their ability to bind to ligands and allows you to save the structural and functional organization of biomembranes.
Special attention should be paid to the fact that the Armadin preparation instructions (injections) describe the main features of its action, and also indicate the normalization of metabolic processes in the ischemic myocardium, reduction of the necrosis zone, restoration and subsequent improvement of electrical activity and myocardial contractility, and also a significant increase in coronary blood flow in the area of ischemia. The use of this drug contributes to the long-term preservation of ganglion cells of the retina, as well as fibers of the optic nerve in case of progressive neuropathy, which can result in hypoxia and chronic ischemia.
Among the additional effects, special attention should be paid to the improvement of the functional activity of the optic nerve and retina, which increases the visual acuity of a person.
Pharmacokinetics
With the intramuscular injection of this drug, the drug is determined in the blood plasma for four hours. The total time to reach C max is approximately 0.45 to 0.5 hours.
It is worth noting the fact that the drug quickly enough begins to pass from the bloodstream to various tissues and organs, and then is excreted from the body. This occurs with urine, in most cases in a glucuronoconjugated form and in small quantities, and unchanged. It is in this that the peculiarities of how the drug “Armadin” (injections) are derived are contained. The composition of this tool includes ethyl methylhydroxypyridine succinate, which is rapidly absorbed into the gastrointestinal tract.
Ethylmethylhydroxypyridine succinate in the human body begins to be metabolized quite intensively with the further restoration of its glucuronoconjugate. In the predominant majority of cases, approximately 0.3% of the unchanged drug is excreted in the urine over approximately 12 hours, while 50% is already in the form of a glucuronoconjugate.
As intensely as possible, eilmethylhydroxypyridine succinate together with its glucuronoconjugate are excreted during the first four hours after using this drug. Quite often, the Armadin drug (injections) reviews of doctors include data on the fact that urinary excretion rates of this element and its metabolites differ in significant individual variability.
When is it taken?
As you know, this tool is available in two forms - these are injections and standard tablets. Each option is used in various cases, so you need to understand correctly when and which one is better to choose. In the overwhelming majority of cases, doctors who prescribe this drug, independently indicate the form of its administration.
Injections
For Armadin (injections), the instruction indicates that its use in this form is indicated in the following cases:
- the presence of acute disorders in the system of cerebral circulation;
- consequences of various head injuries;
- cardiopsychoneurosis;
- encephalopathy;
- the presence of any anxiety disorders in the course of neurosis-like and neurotic conditions;
- small cognitive impairment in atherosclerotic genesis;
- the occurrence of primary open-angle glaucoma of various stages (in this case, the Armadin drug (injections), the instruction indicates that its use is indicated as an element of complex therapy);
- relief of withdrawal symptoms in case of alcoholism, if neurocirculatory and neurosis-like disorders predominate.
Tablets
This form of medication has several other indications for use:
- neurosis-like or neurotic conditions with various symptoms of anxiety;
- consequences of acute disturbance in the cerebral circulation system;
- cardiopsychoneurosis;
- encephalopathies of different genesis;
- mild cognitive impairment of various origins;
- memory impairment or the presence of intellectual impairment in people in old age;
- minor head injuries and their consequences;
- absinthe syndrome in the process of alcoholism with the presence of vegetative-vascular or neurosis-like disorders;
- all kinds of asthenic conditions or the influence of extreme factors;
- conditions of subsequently developed intoxication with various antipsychotropic drugs;
- Ischemic heart disease;
- cardiology in the complex of therapy;
- atherogenic type dyslipoproteinemia.
How to give injections?
So, the doctor prescribed Armadin. Injections intramuscularly or intravenously can be administered by drip or stream. Doses in each case are selected exclusively using an individual approach, as a result of which qualified doctors should do this.
When using the infusion method of administration, this drug should be diluted in physiological solution of sodium chloride. It is recommended to begin treatment of adults with a dose of 50 to 100 mg, which is administered one to three times a day. In the future, volumes may increase, as indicated by the instruction “Armadin” (injections). Ampoules contain the drug itself, which should be slowly injected over a 5-7 minute stream, while drip Armadin is injected at a speed of about 40-60 drops every minute. The maximum possible daily dose of this medication is 800 mg.
In the presence of any acute disturbances in the system of cerebral circulation, the drug is prescribed as a part of complex therapy for 2-4 days, intravenously dripping adults 200-300 mg once every 24 hours, after which it is already used as intramuscular injections in doses of 100 mg per three times a day. In this case, the duration of treatment can reach fourteen days.
If we are talking about traumatic brain injuries or their various consequences, this drug is used for 10-15 days by intravenous administration in a volume of 200 to 500 mg 2-4 times a day.
The drug “Armadin" (injections) is prescribed for discirculatory encephalopathy in the stage of decompensation, where it is used intravenously by drip in doses of 100 mg two or three times a day for 14 days, after which it is already used intramuscularly for two weeks for 100 mg twice a day. In addition, the drug is also used in the course of course prevention of discirculatory encephalopathy in adults through intramuscular injection of 100 mg twice a day for a period of 10 to 14 days.
With myocardial infarction
If the patient suffered an acute myocardial infarction, then the Armadin drug (injections) is administered intramuscularly or intravenously for 14 days against the background of standard therapy, which includes all kinds of thrombolytics, ACE inhibitors, sympathic, antiplatelet and anticoagulant agents, as well as nitrates. During the first five days it is used in order to achieve the maximum possible effect, while it is recommended to use the drug intravenously. Over the next nine days, the possibility of intramuscular administration is already provided.
Intravenous administration is carried out by drip infusion, and at the same time, the drug should be administered slowly to eliminate the risk of side effects. The medication is used in a 0.9% sodium chloride solution or in a 5% dextrose solution in a volume of about 100-150 ml. The introduction is carried out over 30-90 minutes. If necessary, the drug “Armadin" (injections) is prescribed by slow jet administration for at least 5 minutes.
The drug should be administered three times a day every 8 hours. The daily therapeutic dose in this case is from 6 to 9 mg per kilogram of body weight of the patient, and a single dose is, respectively, 2-3 mg / kg of body weight. The maximum possible daily dose is 800 mg, while a single dose of no more than 250 mg is recommended.
Other diseases
In the presence of absinthe alcohol syndrome, the drug is administered at a dose of 100-200 mg intramuscularly from two to three times a day or can be used drip intravenously 1-2 times a day for 5-7 days, as indicated by the Armadin tool application (injections). Doctors' reviews also suggest that in the presence of acute intoxication with antipsychotics, the medication should be administered exclusively intravenously in doses of 50 to 300 mg daily for 7-14 days.
In the presence of any purulent-inflammatory processes in the abdominal cavity, the drug is prescribed on the first day as preoperative, and then as postoperative therapy. In this case, the dosage will directly depend on the severity and form of the disease, the clinical course and prevalence of the process. It is worth noting the fact that if it is necessary to cancel this drug, it should be carried out gradually, and only after a stable positive clinical and laboratory effect is achieved.
If acute edematous pancreatitis occurs, the medication is used in doses of 100 mg three times a day, intravenously, or intramuscularly, depending on the doctor's testimony.
special instructions
Special attention should be paid to prescribing the drug to patients with a burdened allergic history. In certain cases, people with AD in the presence of excessive sensitivity to sulfates may experience the development of severe hypersensitivity reactions. After parenteral administration is completed , in order to maintain the achieved effect, it is recommended to continue using this drug inside in the form of tablets.
There were no strictly controlled clinical trials regarding the safety of this drug when taken during breastfeeding or pregnancy, so doctors do not recommend its use during this period. Similarly, studies have not been conducted regarding the safety of the drug in the process of its use for the treatment of children, and therefore its use is also not recommended for them, even in the case of the above diseases.
Among other things, it is worth noting the fact that during treatment it is necessary to observe extreme caution when driving vehicles or using various mechanisms, as indicated by the instructions for use (injections) to Armadin. Analogues of this drug often differ in similar side effects. This, for example, such as "Mexidol", "Mexicoor", "Mexiphine", "Neurox".
Against the background of prolonged use of the described medication, a certain number of side effects may appear, including weakness, flatulence, or peripheral edema. When administered intravenously (this especially applies to inkjet), a metallic taste may appear in the mouth, sore throat, sensation of heat throughout the body, palpitations, tachycardia, hyperemia of the face and a number of other effects, which is associated with the too high rate of administration of Armadin ( injections). Reviews suggest that these consequences are short-lived.