In the article, we will consider instructions for the use of Kabiven, a drug for nutrition by intravenous infusion.
There are many different diseases that lead to extremely serious consequences and require long-term inpatient therapy. So, some patients can not eat food on their own, why they have a need for the use of special drugs. The drug "Kabiven Peripheral" is a complex that replenishes the protein and energy deficiency of the body. It contains all the minerals and essential amino acids to normalize the metabolic process. It is a good parenteral nutritional supplement.
Characteristics of this drug
The drug "Kabiven Peripheral" is different in that it consists of three components that are in a balanced ratio. It is distinguished by:
- The presence of vamin, acting as an amino acid solution with maximum biological value.
- The presence of intralipid, a fat emulsion with unrivaled safety. It is worth noting that this is the most commonly used fat emulsion in Europe.
- The presence of eleven percent glucose.
The pharmacological effect of the use of this drug
According to the instructions for use with Kabiven, the therapeutic effect of this drug is due to the combination of its constituent properties. The intralipid substance makes up for the lack of fatty acids and contains the required amount of phospholipids, which help to provide the body with energy reserves. Vamin 18 Novum is a complex of amino acids and minerals. In turn, the proline, which is part of this complex, is necessary for tissue repair after injury and surgery. It promotes the production of collagen and other structural components.
The alanine component is an amino acid that is involved in glucose metabolism. This acid stimulates the release of glucose from glycogen depots, preventing the development of hypoglycemia.
The substance methionine is a strong antioxidant. They prevent the destruction of cells under the influence of free radicals. This component can bind toxins, accelerating their removal from the body. Glycine is required to restore brain function. This amino acid is involved in the transmission of nerve impulses and metabolic reactions occurring in the nervous system.
Sodium, in turn, takes part in the transport of cellular work intended for the process of ion exchange. Calcium is required for the operation of many enzymatic systems. Glucose (11% solution) takes part in any metabolic processes and acts as the main energy substrate, which is necessary for the healthy functioning of organs and systems.
What is the composition of this drug
The composition of the Kabiven Peripheral medicine includes intralipid, which replenishes the stores of fats in the human body.
The energy substrate in question contains an eleven percent glucose solution.
The main source of minerals and amino acids in the composition of the “Peripheral Cabiven” is the vamin complex.
This medicine is delivered packaged in a plastic three-chamber container, the contents of which are administered intravenously to the patient. Next, we will consider the indications for the use of this medical product.
Indications for the use of a drug
The indication for the use of “Cabiven Peripheral” means, as a rule, is the need to provide the patient with parenteral nutrition, bypassing the gastrointestinal tract. It is also used to treat protein and energy deficiency, which accompanies many different diseases. Now find out what this drug has side effects.
Side effects from the use of this drug
Side effects of the drug for parenteral nutrition can occur in the form of allergic reactions, hypertension, hypotension, and, in addition, in the form of headaches or abdominal pain. At the injection site, thrombophlebitis may develop.
Compliance with the rules of the instructions for using the Kabiven tool will minimize undesirable manifestations.
Contraindications are the following pathologies: the presence of hyperlipidemia, kidney failure, impaired liver function and blood coagulation.
Side effects of the “Cabiven Peripheral ” are described in detail in the instructions.
Pregnancy and lactation: is it safe to take?
No studies have yet been conducted to obtain information about the effect of the drug in question on the body of pregnant women and infants. Pregnancy along with lactation are a relative contraindication. The use of this drug for this category of women is justified only if the therapeutic result clearly prevails over the possible risks.
Instruction manual
The drug "Kabiven" is prescribed in the format of infusion treatment, it is injected into peripheral veins. The dosage of the drug in question depends on the overall degree of exhaustion of the patient and his natural needs for nutritional components. Immediately before use, remove the clips and mix the contents of the cameras. The speed of the infusion is determined by the doctor, taking into account the severity of the condition of a particular patient.
The maximum daily dose is 40 ml / kg / day for an adult. Children from two to ten years old require 14-28 ml of the drug per kilogram of body. Children over 10 years of age are given doses, as are adults. The rate of administration of the drug should not be higher than 3.7 ml / kg / h.
Features of use
The dosage of this tool depends on the purpose of use. During periods of admission, it is necessary to monitor the coagulation index of the patient. When mixing solutions, it is necessary to adhere to the rules of asepsis in order to prevent infection.
Alcohol interaction
The considered medicinal product is used as part of parenteral nutrition for medical support of seriously ill patients. In a hospital, the use of alcohol is prohibited.
Compatibility with other medicines
It is worth noting that the drug "Heparin" affects lipid metabolism. This remedy can accelerate or inhibit lipolysis. Insulin has similar properties.
The drug "Kabiven Peripheral" can be combined with other drugs only under the supervision of a doctor. It penetrates the bloodstream and is distinguished by systemic manifestations.
Overdose
Against the background of the intake of this solution into the body in high dosage, patients may experience fat overload syndrome, expressed in hyperlipidemia. Also, the appearance of a reaction in the form of agranulocytosis, thrombocytopenia, an increase in temperature and in the form of the development of hepatomegaly is not ruled out. Subsequently, a coma may occur. Therapeutic methods are to completely stop the infusion and eliminate unwanted symptoms.
Similar drugs
The means intended for parenteral nutrition include Alvesin, which contains a complex of trace elements and amino acids. Among group analogues, it is worth noting medications in the form of "Lipofundin", "Aminosole", "Intralipida". All of these medical devices have a similar composition.
Terms of sale
A medicine called “Cabiven Peripheral” is intended for the treatment of patients in a hospital. It is worth emphasizing that this remedy is not available for purchase in ordinary pharmacies.
Reviews for "Peripheral Cabiven"
The medication in question is intended to make up for a deficiency of amino acids and all kinds of microelements in patients. Often this tool is used by resuscitators, who in their reviews indicate an improvement in the general condition of patients, and, in addition, to accelerate the healing process. Relatives of seriously ill people also noted progress in treatment after using this medication.
Storage rules
Kabiven is stored at a temperature that should be less than twenty-five degrees. Subject to the integrity of the package, this remedy is suitable for use for two years from the date of issue. Immediately after opening and mixing the ingredients, it is permissible to store the medicine for twenty-four hours at a temperature of about twenty-five degrees.
The ingredient of the drug "Kabiven"
L-tyrosine is propionic acid. It belongs to aromatic alpha amino acids. In structure, this compound may differ from phenylalanine by the presence of a phenolic hydroxyl group in the position of the benzene rings. From a biological point of view, less important meta-isomers of L-tyrosine are known.
Intralipid substance as an ingredient in the drug
The intralipid component (20%) is a source of energy, and in addition, essential fatty acids. This substance contains purified soybean oil along with emulsified purified egg yolk phospholipids. Soybean oil, in turn, consists of a mixture of predominantly polyunsaturated fatty acids. Phospholipids are isolated from egg yolk. The sizes of lipid globules, along with the biological properties of intralipid, are identical to chylomicrons. The pharmacokinetics of this ingredient has not been studied.
Vamin component as an ingredient in the drug
An indication for the use of this substance is the parenteral nutrition of patients if they have a significantly increased need for protein. Contraindications to the use of this substance are the presence of hypersensitivity in the patient along with liver failure and uremia (in the absence of the possibility of dialysis).
It is worth noting that, at the same time as your infusion, an intralipid or dextrose solution is administered, since an increase in calorie intake can contribute to the optimal degree of utilization of amino acids, and the risk of thrombophlebitis decreases from dilution of the concentration. Learn more about the benefits of this tool.
Benefits of the drug
The advantages of the described medical device are the following advantages:
- The presence of an optimally balanced composition.
- Manufacturability along with convenience and ease of use.
- Reducing the risks of infectious complications.
- The ability to add vitamins along with trace elements and "Dipeptiven" through the use of a special port.
- The ability to enter a therapeutic agent into the central, and in addition, into peripheral veins.
Parenteral drug
Parenteral nutrition is used when it is forbidden to satisfy the body's needs in a natural way, that is, by habitual feeding through the mouth or through the use of a probe. General medical indications for this are toxic conditions in the form of coma, non-stopping vomiting, extensive burn injuries, multiple and combined injuries, maxillary and facial injuries, after operations on the organs of the digestive system, as well as during the early postoperative period.
Parenteral nutrition is either full or partial. Patients need to satisfy their body's energy needs, amino acids, essential fats, minerals and vitamins. But, unfortunately, this universal drug does not exist; in this regard, a combination of different solutions is used for parenteral nutrition. Carbohydrates are the main source of energy: 1 gram of glucose gives the body 4.1 calories.
A five percent glucose solution is a form of isotonic solution. But it is worth noting that in 100 milliliters of such a solution contains only 20 calories. In order to meet the daily energy requirements, 12 liters of such a solution are required. Therefore, concentrated glucose solutions of ten, twenty and thirty percent format are used.
There are many different diseases that lead to serious consequences and require prolonged hospital treatment. Some patients are simply unable to eat on their own, and against this background, there is a need for the use of funds intended for parenteral nutrition. A drug called “Kabiven” is just a complex that replenishes protein and energy deficiency. It contains all the necessary amino acids along with minerals to normalize the metabolic process in the body.