"Tsifran ST" is a combined drug with the active substances tinidazole and ciprofloxacin. It is intended for the treatment of infectious diseases of the gastrointestinal tract and mixed infections, the development of which was promoted by aerobes and anaerobes.
Several forms of the “Tsifran” preparation are being manufactured. Forms of release of the drug - tablets in the shell, eye drops, solution for infusion.
Tinidazole is formed from imidazole. The tool has an antimicrobial and antiprotozoal effect, it is used for diseases caused by anaerobes.
Ciprofloxacin refers to antibiotics that have a wide range of effects. Aerobes are sensitive to it (most of the aerobes, which are gram-positive, gram-negative).
Both the original and analogues of “Tsifran ST”, effectively cope with the tasks.
Pharmacodynamics
Tinidazole, which affects anaerobes, is effective in treating the affected lung, organs located in the oral cavity, in the peritoneum and in the small pelvis.
Since anaerobic infections are mostly mixed (develop under the influence of aerobes and anaerobes), the drug contains an antibiotic ciprofloxacin, which inhibits bacteria belonging to aerobes.
Pharmacokinetics
The main substances that make up the original drug and analogues of “Tsifran ST” are well absorbed in the digestive tract and spread through tissues and liquid media. Their maximum concentrations are observed in the body on average 1.5 hours after the penetration of the drug into the digestive tract.
Tinidazole has a bioavailability of 100%, partially excreted in 10-12 hours. Communication with blood plasma proteins is negligible - 12%. Excretion in bile occurs, about 25% of tinidazole is excreted in the urine unchanged. Metabolites are eliminated in the same way. An insignificant part of the component leaves the body with feces.
Ciprofloxacin with a bioavailability of approximately 70% is most easily absorbed by internal use. Penetrating into the body along with food, the component, which has in its composition "Tsifran ST" (analogue in active substances) is absorbed more slowly. Ciprofloxacin binds to plasma by 20-40%. Partial metabolism occurs in the liver, half the dose taken penetrates the urine, excreted unchanged. About 15% of ciprofloxacin takes the form of metabolites and is excreted in this form, 15-30% are removed with feces, the remainder with bile. Partial excretion requires an average of 4 hours, but this period may be longer in elderly patients and in the presence of pronounced renal impairment in the patient.
Indications for the use of the drug "Tsifran ST"
Let us consider in what cases the use of the “Tsifran” means allows for instructions for use. Price and analogues of this drug determine the effectiveness of the treatment of the following diseases:
- mixed infections, the development of which occurred under the influence of bacteria (aerobes and anaerobes);
- diarrhea and dysentery of various etiologies (amoebic, mixed (bacterial and amoebic)).
The drug is suitable for the treatment of such mixed infections:
- infectious processes in the organs of the oral cavity (including periostitis, periodontitis);
- pressure sores;
- trophic ulcers in diabetic foot syndrome;
- infectious processes affecting soft tissues, skin;
- chronic osteomyelitis;
- infections resulting from surgery and resulting from exposure to bacteria (aerobes, anaerobes);
- gynecological diseases of an inflammatory nature;
- infections in the peritoneum;
- empyema;
- lung abscess;
- sinusitis, which has become chronic.
Contraindications
Not in all cases, you can take "Tsifran." Reviews, analogues will allow you to choose the appropriate treatment options.
The instruction prohibits the use of the drug in the presence of some problems:
- organic diseases of the central nervous system;
- acute flowing porphyria;
- bone marrow pathology (hematopoietic process is impaired);
- blood diseases (history).
Contraindications are also hypersensitivity to the components of the drug, bearing a child, breastfeeding. The medicine is not prescribed for patients under 18 years of age. The instruction "Tsifran ST" does not allow the use of alcohol.
Taking the medicine in old age has some features, so be sure to follow the recommendations of the attending physician. Caution is required when:
- severe violations in the liver and kidneys;
- convulsive conditions (history);
- epilepsy;
- mental illness;
- circulatory disorders in the brain;
- atherosclerosis of blood vessels located in the brain.
Use of the drug, dosage
"Tsifran ST", an analogue of a medicinal product, has different methods of use and is used in different doses. The original drug, intended for internal use, is taken after meals (2 times daily). "Tsifran ST" is washed down with a large amount of water. It is forbidden to violate the integrity of the pill, you need to drink it whole.
The recommended dose for adult patients is:
- tablets, in the composition of which ciprofloxacin and tinidazole are present in 250 and 300 mg, respectively - 2 pieces;
- tablets containing ciprofloxacin and tinidazole of 500 and 600 mg - 1 piece.
With topical use of the drug for an inflamed eye, one or two drops of the drug are required. Treatment should be done at intervals of 1-4 hours. If the condition improves, the interval can be increased.
Side effects of the drug "Tsifran ST"
"Tsifran ST" (analogue to the main substances) can provoke some undesirable reactions.
Digestive system:
- hepatonecrosis;
- hepatitis;
- cholestatic jaundice (the highest risk of its development in patients with a sick liver);
- diarrhea, flatulence, pain in the abdomen;
- nausea and vomiting;
- unpleasant taste of metal in the mouth;
- poor appetite;
- dry mucous membrane of the oral cavity.
Nervous system:
- thrombosis affecting the cerebral arteries;
- fainting
- high ICP;
- migraine;
- dizziness, headache;
- psychotic reactions;
- increased sweating;
- lack of sleep;
- tremor;
- weakness, fatigue;
- cramps
- peripheral neuropathy;
- dysarthria;
- problems with coordination of movements.
It also notes other undesirable manifestations of the “Tsifran ST” instruction. The price in pharmacies, analogues determine not only the effectiveness of the drug, but also the presence of some side effects.
Sensory organs:
- visual impairment;
- change in sense of smell;
- violation of taste;
- bad hearing.
The cardiovascular system:
- low blood pressure;
- changes in the rhythm of the heart;
- tachycardia.
Urinary system :
- interstitial nephritis;
- problems with urine excretion;
- excessive urine formation;
- damage to the glomeruli of the kidneys;
- urine excretion with the formation of salt crystals in it;
- determination of blood in the composition of urine.
Allergies and other undesirable effects, changes in laboratory parameters, various disorders in the hematopoietic system are possible.
Drug interaction
“Tsifran ST” (analogue for active components) should not be combined with “Ethionamide”. The drug is combined with certain antibiotics and sulfonamides.
When used with Phenobarbital, an accelerated metabolism is observed. The drug enhances the action of ethanol and anticoagulants.
special instructions
During therapy, you need to stay as little as possible under the influence of sunlight. It is forbidden to engage in activities that, when treated with a drug, can endanger health (requires attention, rapid manifestation of motor and mental reactions). During therapy, it is necessary to monitor peripheral blood.
Analogs, reviews, price
When prescribing "Tsifran ST" analogues, the price is important for patients. Most commonly used tablets. The cost of tablets with a content of basic substances of 250 and 300 mg is approximately 36-460 rubles, the price of tablets with 500 and 600 mg of the main components is about 79-500 rubles.
What can replace "Tsifran ST"? Russian analogs are cheaper. The original drug can be replaced, for example, with Ciprofloxacin (10-25 rubles). From Indian counterparts, you can choose "Tanidazole + Ciprofloxacin" or "Ciprolet A" (150-325 rubles). It is with these drugs that Cyfran ST is mainly replaced.
Judging by the reviews, the original drug copes well with the common cold, especially if the disease is running. When used in the early days of the menstrual cycle, it can cure many female inflammations. "Tsifran ST" quickly eases the patient's condition.
Basically, an antibiotic is used after surgery and in cases where serious inflammation occurs in the body that does not disappear for a long time, since there are a lot of side effects. In the reviews, buyers note that analogues are no less effective and easier to carry.
The drug "Tsifran ST" is taken only after examination and appointment by a doctor. Do not self-medicate, as the consequences can be serious.