If it is necessary to lower cholesterol concentration in the circulatory system, Atoris tablets can be used. In the instructions, the manufacturer indicates that the drug is used strictly under the supervision of a doctor, since there is a risk of side effects. Sales statistics show that the drug in recent years is in great demand. Some patients are prescribed it for life. However, it is worth noting, especially in comparison with analogs, that Atoris will not be a very serious burden for the family budget: for each package in pharmacies they ask from 90 rubles, while analogues mostly cost several times more.
What's on sale?
The drug is made in the form of tablets. The instructions for Atoris indicate that one tablet contains the active compound atorvastatin, as well as auxiliary components. The amount of the basic substance varies, the exact parameters are necessarily indicated on the outside of the package. There are three forms of release: 10, 20, 40 mg of atorvastatin.
Various components have been used as auxiliary compounds, including lactose monohydrate. This imposes certain restrictions on the possibility of using the drug (they are indicated in the instructions). "Atoris" should not be used by persons who do not tolerate lactose. And also those whose body is too sensitive to it.
One cardboard box contains instructions and Atoris in the form of tablets packaged in blisters. The blister contains a dozen doses. In one package - from one to nine blisters. The manufacturer indicates the exact quantity on the outside of the package. The name of the drug and the name of the manufacturer, conditions of dispensing and storage, the date of manufacture of the medicine are also written here.
Pharmacology
The instructions for Atoris indicate that the medication can reduce the content of lipid compounds in the blood plasma. The effectiveness of the drug is due to the active component included in its composition - atorvastatin. This compound is able to inhibit the enzyme GMK-CoA reductase, to prevent the formation of mevalonic acid, as it slows down the enzymes necessary for such a chemical process.
As clinical trials have shown (and this is fixed in the instructions for the medicine), Atoris lowers the overall cholesterol inherent in the circulatory system. This is primarily due to the reduction in the number of low-density lipid compounds.
Atorvastatin has a pronounced effect on the metabolic processes inherent in the life of macrophages. Under its influence, reactions are stopped in which isoprenoids could be formed, initiating cell proliferation of smooth muscle fibers of the vascular system. In addition, the drug has an effect on aggregation, blood coagulation. The instructions for use of Atoris (20 mg and other dosage forms) indicate that the drug improves the quality of blood flow, fights atherosclerosis, and reduces the likelihood of tearing off plaques that appear on the inner walls of blood vessels due to atherosclerosis.
Processing specifics
The instructions for Atoris (20 mg, 10 and 40 mg) indicate that the active compound, when taken orally, is soon absorbed from the intestinal tract. The highest levels in blood plasma are achievable in an hour, although in some cases it takes up to four hours. The speed of the absorption process is slightly reduced if you use the medication during the meal. The ability to communicate with plasma proteins reaches 98%. The active component cannot penetrate the blood-brain barrier.
The manufacturer draws attention in the Atoris instructions (20, 10, 40 mg) to the localization of processing processes: metabolism occurs in the liver. The main route of elimination is the intestinal tract. About 2% of the substance leaves the body through the kidneys. The elimination half-life is estimated at 14 hours.
When to take?
According to the instructions, Atoris tablets are indicated for primary hyperlipidemia, if the case belongs to categories 2a or 2b. You can use the medication if polygenic, hereditary heterozygous hypercholesterolemia is established. The tool is effective in mixed forms of hyperlipidemia.
You can use the drug if hypercholesterolemia is hereditary homozygous, but there are certain limitations: total cholesterol must be strictly higher than the average for a person. In addition, for the appointment of Atoris, it is necessary that the concentrations of low-density lipoproteins, apolipoprotein B, and triglycerides be higher than normal.
Therapy Features
The instructions for the use of Atoris tablets indicate that the drug is allowed only for those patients who adhere to a low-fat diet. Transfer to this diet is carried out before the start of the course. Food restrictions will have to be considered throughout the treatment.
The tablets are intended for oral use. You can take them at any time, there is no attachment to meals. According to the instructions, Atoris (40 mg, 10 or 20 mg) is used once a day, therefore it is reasonable to adhere to one stable time. This will allow the course to achieve the most pronounced effect.
The duration of the program, the dosage should be determined by the attending doctor. The doctor focuses not only on the instructions for the use of Atoris (10 mg, 20 mg, 40 mg), but also the features of the patient's condition: diagnosis, the specifics of the work of internal systems and organs, contraindications, tendency to allergies. Since the course of the disease can develop according to a huge number of scenarios, it is impossible to draw up a standard course suitable for almost everyone.
Adults and children
About all the rules for taking pills tells the instruction "Atoris". 10 mg is the initial dose. This amount of the drug is taken as food, not dividing by approaches, the frequency per day - once. A pronounced effect can be observed after a couple of weeks from the start of the course, the greatest is achieved by the 28th day of treatment.
If two weeks after the start of the use of the drug is still not effective, the dosage is increased. The manufacturer allows you to take no more than 80 mg of the active component per day. Between successive increases in dosage, two-week intervals must be maintained. Dosage adjustment is carried out on the basis of a lipid profile taken every two weeks of the course.
The instructions for use and reviews about "Atoris" contain information about the possibility of using the medication for children. The drug is allowed at the age of ten years and older. Therapy is started (as in adults) with 10 mg daily, using the medicinal composition stably at the same time of day. In the absence of a pronounced effect, an increase in dosage is allowed, according to the instructions for use. Atoris 20 mg (reviews prove that this amount is mainly enough for minor patients) - the maximum release format available to children. The manufacturer draws attention to the fact that more than 20 mg of the active compound should not enter the child's body per day. Between four-week intervals, dosage intervals must be maintained. Correction of the format of the course is carried out after receiving information through a lipidogram.
Special occasion
As confirmed by numerous reviews, the instructions for use "Atoris" is recommended for people of different age groups, including elderly patients. Special dosage adjustment for this category is not required. If abnormal kidney function is established, in general, the dose should not be changed.
If violations of the liver are detected, it is necessary to carefully raise the dosage of the drug. The manufacturer in the instructions for use "Atoris" (40 mg and other forms of release) indicates that the increase is made only subject to constant monitoring of the concentration of lipids in the circulatory system. The patient must be kept under observation to note the clinical features of the condition. If hepatic enzymes during the use of the composition become more active than the norm three times or more, the medication is immediately canceled.
Negative consequences
As indicated in numerous reviews of Atoris (instructions for use of 10 mg, 20 and 40 mg confirm this), the drug rarely provokes a negative response of the body. As a rule, the medication is well tolerated. At the same time, negative effects are possible. As follows from clinical trials and patient reviews, the instructions of Atoris are possible:
- impaired appetite;
- dyspepsia;
- hepatitis;
- pancreatitis
- insomnia;
- pain and dizziness;
- numbness of the limbs;
- neuropathy
- myopathy
- soreness, muscle weakness;
- increased activity of liver enzymes;
- hypo-, hyperglycemia;
- allergic reactions;
- asthenia;
- sexual problems;
- hair loss;
- pain behind the sternum.
In the reviews of Atoris, the instructions indicate that the presence of a negative response may be a reason for stopping therapy. Patients who experienced such consequences of admission consulted a doctor. The doctor, based on the patient’s condition, decided to discontinue the course and replace the drug with a more suitable one. In some cases, the side effects are rather mild, while the benefits of the course are pronounced, so it is reasonable to continue the application, while using means to alleviate the negative manifestations.
Strongly impossible!
Like all analogues based on the same compound, the instructions for use of Atoris indicate the impossibility of using the composition with intolerance to atorvastatin. In addition, the drug can not be taken if the patient does not tolerate any other substances used by the manufacturer in the manufacture of the medication. A categorical ban on admission is imposed by:
- lack of lactase;
- galactosemia;
- glucose galactose absorption problems;
- acute renal impairment;
- increased transaminase activity;
- skeletal muscle disease;
- pregnancy;
- lactation;
- children's age (under 10 years old).
Specific restrictions
Both analogs similar in active components and Atoris (instructions for use emphasize this) can be used to treat persons suffering from alcohol addiction only if it is possible to constantly monitor the patient's condition. A similar approach requires impaired functioning of the liver, a disease of this organ.
The manufacturer indicates the inadmissibility of resorting to the tool during gestation. Before the start of the course, special studies are carried out in order to completely exclude pregnancy. It is not recommended to use the medication for women of reproductive age, and if necessary, it is important to use reliable contraceptives. If conception is planned, Atoris should be completely abandoned at least one month before the planned moment of pregnancy.
During the period of breastfeeding, you must either abandon the medication, or stop feeding and transfer the child to artificial nutrition.
As for many analogues, the Atoris manual and reviews (20 mg, 10 or 40 - the dosage does not matter) confirm that the drug may slightly affect the patient’s ability to concentrate, therefore it is recommended not to drive transport during the course of treatment. If you need to concentrate and solve complex problems, it is important to be especially careful.
Mutual influence
It is known that the simultaneous use of Atoris and substances that affect CYP 3A4 in food can cause an increase in the amount of atorvastatin in the blood plasma, which means that the risk of myopathy, impaired renal function, and rhabdomyolysis increases.
The simultaneous intake of atorvastatin, niacin, and products derived from fibroic acid leads to an increase in the concentration of the active component of the medication in the circulatory system.
When combined with phenytoin, atorvastatin shows a more pronounced effect, but combination with antacids leads to a decrease in plasma concentrations of the active compound. As studies have shown, this does not affect the effectiveness of the therapeutic program.
Atorvastatin plasma levels can be reduced if medications with colestipol are used simultaneously with the substance. Studies have shown that this combination leads to increased effectiveness of the treatment program as a whole.
The combination with digoxin, oral contraceptives provokes an increase in the concentration in the blood plasma of these compounds, but does not affect the amount of atorvastatin. Concomitant use with warfarin causes a decrease in prothrombin time. This is especially pronounced at the beginning of the therapeutic course. Over time, the effect is leveled out naturally.
The described drug and grapefruit juice are not strictly combined.
Too much!
There is no confirmed data on an overdose of Atoris. If this situation does occur, urgent gastric lavage is required. The patient is shown sorbents and therapy aimed at eliminating the symptoms that occurred during an overdose. The same information is indicated in the reviews of Atoris.
Analogs
The instructions for use indicate that the active component of the drug is atorvastatin, therefore, to some extent, alternatives for this drug are drugs based on the same compound. Different variants of Atorvastatin medicine, produced by many modern pharmaceutical companies, both foreign and domestic, are in greatest demand.
Whatever Atoris analogue is chosen, the instructions for use of this substance will have to be observed very clearly. It is necessary to coordinate the replacement with the treating doctor, otherwise the probability of the ineffectiveness of the therapeutic program is high. Incorrect replacement of the medication can provoke side effects.
In some cases, the tool is replaced by:
- Atomax
- "Anvistat";
- "Vazator".
Possible replacement by "Tulip", "Torvas", "Lipoford". The doctor should be warned about the need to choose an alternative, indicating for what reasons it is not possible to take the initially prescribed composition. The doctor will be able to choose the best option, focusing on the needs of the patient.
Tulip
The reviews indicate that the Tulip medication is in greatest demand among all alternative options for the drug in question. The tool also stops the activity of reductase HMG-CoA, which means it reduces the concentration of total cholesterol and triglycerides in the blood.
On sale "Tulip" is represented by tablets of different dosage options: 10, 20, 40 mg of the active component. Each of the options has its own individual characteristics. The option with the minimum dosage is available in white or close to this, twice as much - in light yellow. Tablets containing 40 mg of active compound are made in a brownish tint of yellow. On each instance, the manufacturer indicates how many active compounds are contained in the preparation. This avoids confusion.
Tablets are packed in blisters of ten. Tulip is sold in cardboard packs containing from three to nine blisters. The price for such packaging is from 200 rubles and above.
In addition to the active compound of atorvastatin, the drug contains auxiliary elements:
- talc;
- titanium dioxide;
- carmellose;
- lactose;
- cellulose;
- polysorbate;
- magnesium stearate;
- hyprolose;
- macrogol;
- dye.
Terms of use: when shown?
As indicated in the instructions, "Tulip" under the supervision of a doctor can be taken if installed:
- hypercholesterolemia (primary, familial heterozygous, non-familial);
- hyperlipidemia (mixed).
"Tulip" can only be used in combination with a special diet designed to minimize the intake of fatty compounds in the body. The main purpose of the drug is to lower the amount of cholesterol in the circulatory system, both general and low-density. The active component of the drug affects apolipoprotein B, thyroglobulin. At the same time, more high-density fat proteins can be achieved relative to total cholesterol.
"Tulip" is indicated if the patient is already undergoing treatment with diets and other non-medication, but such options do not give a pronounced result.
If hypercholesterolemia of a hereditary type of homozygous form is detected, the drug can be used as an effective method of reducing the amount of total cholesterol and low-density, if alternative routes do not show the desired effect.
“Tulip” is recommended for people who have complications due to heart and blood vessel diseases, while there are no signs of ischemia, but there is a risk of developing such a condition. "Tulip" is indicated for smokers, as well as people suffering from high blood pressure, diabetes mellitus and retinopathy, since it reduces the risk of ischemia. , :
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Application rules
The use of "Tulip" is possible only in case of preliminary practice of a diet, compiled with the calculation of minimizing the amount of cholesterol in foods. Such a nutrition program will need to adhere to the entire period of taking the pills.
"Tulip" is used as food without reference to the meal. The drug is taken once a day. On a day, a dose from the range of 10-80 mg of the active ingredient is indicated. Choose a certain amount, starting with the minimum option, gradually increasing the dose and controlling cholesterol in the circulatory system. Since the reaction to the medication is strictly individual, it is impossible to predict in advance which dosage will be needed.
It is necessary to regularly take indicators of the concentration of fatty structures in the circulatory system. This is done at the beginning of the therapeutic course and with an increase in dosage a couple of weeks after the dose is updated. Based on the obtained analyzes, they decide on the need to adjust the amount of atorvastatin received by the patient.
In the primary form of hypercholesterolemia, with combined hyperlipidemia in most cases, a sufficient amount is 10 mg, used at one time. Less commonly, a dose increase is required; the upper limit is 80 mg. With an increase, it is necessary to carefully monitor the patient’s response, and adjust the dose, maintaining between two to three weeks intervals between changes. This is due to the specifics of the medication: the therapeutic effect of atorvastatin is observed after two weeks, and for a long time, if the course is long.
If familial hypercholesterolemia is established, defined as homozygous, then the optimal dosage is 80 mg. The entire volume is taken at a time, tablets must be used every day.
As a preventative measure in diseases of the heart and blood vessels, Tulip is indicated in an amount of 10 mg. If after some time it is not possible to achieve the recommended level of low-density fatty structures in the blood, the volumes are increased, but the upper limit of 80 mg is taken into account.
Some features
No special approach is required for the treatment of elderly patients. No adjustment is needed for kidney failure.
If hepatic impairment is detected, the elimination of atorvastatin is somewhat slowed, therefore, the drug is used very carefully. To ensure the safety of the patient, it is necessary to monitor the activity of liver enzymes.
The negative effects of taking
As can be seen from the instructions and reviews, “Tulip” can cause a headache, and some patients complained of dizziness. The manufacturer indicates that against the background of the use of tablets are possible:
- asthenia;
- memory impairment;
- paresthesia;
- general weakness;
- violation of the perception of taste, smell, visual image;
- active gas formation in the intestine;
- violation of the stool;
- vomiting
- sudden weight loss;
- hepatitis;
- pancreatitis
- jaundice;
- liver failure;
- sore neck muscles;
- myopathy
- myositis;
- rhabdomyolysis;
- tendon rupture;
- necrotizing myopathy;
- erythema;
- allergic reactions;
- hyper-, hypoglycemia;
- thrombocytopenia;
- nosebleeds;
- anaphylaxis;
- tendency to edema;
- weight gain;
- diabetes;
- gynecomastia.
It is known that in several patients, against the background of the use of tablets, atonic fasciitis was observed, but at present it is not possible to identify precisely whether this was due to taking the tablets or other factors.
Important Nuances
In rare cases, patients have experienced depression while taking the drug.
An overdose of the drug is possible. This requires therapy to eliminate the symptoms. The active compound does not have a specific antidote. Blood dialysis does not show a pronounced effect, since atorvastatin predominantly binds to plasma proteins.
Like other statin-based drugs, Tulip can cause a threefold or more increase in the activity of liver enzymes in blood serum. To ensure patient safety, it is necessary to regularly take indicators and track changes, comparing them with the parameters obtained before the start of the course. Be sure to check after 6 and 12 weeks from the start of the Tulip treatment program.