"Pyrantel" is an anthelmintic drug and is used to treat patients of all age categories.
This medication is made in the form of yellow tablets, convex on both sides. It is used orally. Tablets are packaged in blisters (3 pieces each) and in cardboard packaging, with attached detailed instructions for use. "Pyrantel" has some limitations in use, can cause adverse reactions.
In addition, the medication is available in the form of a suspension, which is a yellowish liquid with fruit aromas, poured into bottles of darkened glass. Bottles are packed in cardboard boxes. There are detailed instructions and a special measuring cup. Instructions for use with the suspension "Pirantel" is also detailed.
The composition of the tablets includes the main substance - pyrantel and some additional auxiliary components: orange flavoring, talc, potato starch, magnesium stearate, ethyl cellulose, povidone.
As the instruction to Pyrantel indicates, the suspension also contains the active substance - pyrantel and auxiliary elements: citric acid monohydrate, emulsion simethicone, povidone, polysorbate, magnesium aluminum silicate, glycerol, sodium benzoate, sodium carmellose, sorbitol, apricot flavor, sodium hydroxide specially purified water.
pharmachologic effect
In accordance with the instructions, "Pirantel" is a medicine against helminths with a wide range of effects. Due to the active component, the muscle apparatus of parasites is blocked, as a result of which they are immobilized and killed. This medication is effective against mature individuals and does not affect eggs and larvae of worms, as well as those parasites that are at the migration stage.
The medication is active in relation to:
- Ancylostoma duodenale.
- Enterobius vermicularis.
- Necator americanus.
- Trichocephalus trichiurus.
Indications for appointment
The Pirantel medical device is prescribed to patients as a prophylactic and therapeutic drug for the following pathologies:
- Ascaridosis.
- Enterobiosis.
- Hookworm.
- Necatorosis
Contraindications
According to the instructions, Pirantel has a certain list of restrictions for use, which include:
- Cases of individual intolerance to the drug.
- Myasthenia gravis
- Children's age up to 3 years (for a tablet dosage form).
- Combination therapy with Levamisole and Piperazine.
- Congenital forms of fructose intolerance (for a medication in the form of a suspension).
- Lactation, pregnancy.
- Anemia with significant depletion of the body.
- The age of the child is up to 6 months and body weight is less than 10 kg.
With extreme caution, the drug should be used among people suffering from severe liver failure or impaired function.
Before using the drug, it is necessary to study in detail the accompanying annotation in order to eliminate restrictions.
The instruction to "Pirantel" should be strictly observed.
Dosage regimen and method of application
The suspension is administered orally during or after a meal. Before use, the glass bottle with the medication must be shaken until a homogeneous emulsion is achieved.
Recommended dosages:
- Children from 6 months. up to 2 years: 2.5 ml - half a measuring cup.
- Children 2 to 6 years: 5 ml - 1 measuring cup.
- Children 6 to 12 years: 10 ml - 2 cups.
- Children from 12 years old and adults weighing less than 75 kg - 3 measuring cups or 3 tablets.
- Adults weighing more than 75 kg - 4 measuring cups or 4 tablets.
In order to prevent re-helminthiasis, a medication is administered 21 days after the first use.
According to the instructions for use of "Pyrantel", in case of ascariasis, enterobiosis or mixed invasion with these parasites, the dose recommended for one course (10 mg per 1 kg of weight) is taken once. With hookworm infection, as well as with a combination of necatorosis and ascariasis or any other helminth infestations, the drug is taken for three days at 10 mg per 1 kg of body weight. The recommended dosage for massive invasion of Necator americanus is 20 mg per kilogram of body weight per day. The duration of the course is two days.
As the instructions indicate, Pyrantel 250 mg should be chewed carefully and taken orally during meals, washed down with water.
Use during pregnancy, lactation
The instructions for "Pirantel" for adults indicate that in the first trimester, therapy with this drug is strictly contraindicated, since scientific studies in this case have not been carried out and it is not known what effect the drug may have on the intrauterine development of the child. In the second and third trimesters, such treatment is possible only in cases where the potential effect for a woman exceeds the likely risk to the fetus.
Instructions for use of "Pyrantel" reports that the active substance of this medication can be excreted in breast milk, so its use during the lactation process is not practiced. If treatment is necessary, the woman is recommended to stop lactation.
Side symptoms
According to the instructions for use and reviews of "Pirantel", during treatment with a pharmacological agent, certain side effects may occur in patients:
- From the digestive organs - nausea, lack of appetite, the occurrence of an unpleasant taste in the mouth, epigastric pain, vomiting, diarrhea, in some cases, changes in liver function are possible.
- On the part of the nervous system - minor headaches, increased irritability, drowsiness, lethargy, weakness. In more severe cases - the occurrence of hallucinations, impaired consciousness, paresthesia.
- Allergic symptoms - skin rashes, itching, urticaria, in severe cases, the occurrence of angioedema.
Overdose symptoms
What else can you learn from the instructions for use of "Pyrantel"? When using an increased dosage of this medication, the patient may develop negative overdose symptoms, which are manifested in an increase in the side effects described above and severe changes in the structures of the nervous system.
Overdose therapy consists in urgent gastric lavage and the use of enterosorbents. If necessary, symptomatic treatment should be carried out. An antidote to this drug does not exist.
The instruction for the use of Pirantel tablets for adults does not end there.
The interaction of the drug with other medications
"Pyrantel" is not recommended for use with concomitant therapy with the drug "piperazine", since with a similar pharmacological interaction, a weakening of the therapeutic effect is noted.
With the simultaneous use of the drug with "Theophylline", the concentration of the latter in the blood increases, which can also lead to negative reactions.
According to the instructions, Pirantel tablets are not recommended to be taken simultaneously with laxatives. This is because the therapeutic effectiveness of the drug will be reduced.
Impact on the ability to control mechanisms
In accordance with the instructions for use of "Pirantel", it is recommended to refrain from driving vehicles and carrying out potentially dangerous types of work during the period of taking the drug. The basis for this is the possible development of dizziness, weakness, drowsiness and other negative phenomena from the structures of the nervous system.
Special recommendations
During the treatment of enterobiasis, it is necessary to prescribe a preventive dosage of the drug to all people who have contact with the patient. A single dose of a medicine will suffice for these individuals. At the end of treatment, the patient must pass a control analysis of feces for the presence of worm eggs and scraping from the perianal fold. To avoid the spread of parasitic infections, it is necessary to wash underwear and bedding carefully, iron it with an iron from different directions. It is also recommended to carry out wet cleaning of the room daily, and wash dishes in hot water with soda.
This is confirmed by the instruction to the "Pirantel". We will consider reviews below.
Analogs
Structural analogues of this medication are three anthelmintic drugs:
- Helminthox.
- "Pirantela Pamoat."
- "Nemocide."
All of the above drugs act on both immature and sexually mature worms, but they are absolutely ineffective against eggs and larvae of parasites.
Similar medications for therapeutic effects are:
- "Biltricid." The main active element of this medication is praziquantel, which is effective against metagonyms, Chinese flukes, liver flukes, pulmonary flukes, giant flukes, schistosomes, fasciolopsis, dwarf tapeworms, bovine tapeworms, wide lentes, pork chains, as well as their larvae.
- "Nemozole" is a medicine based on albendazole. Effective against echinococcus larvae, pork tapeworm, whipworms, lamblia, roundworm, hookworm, intestinal eel, pinworm, opisthorchis, microsporidia.
- "Dekaris" is a drug whose main active element is levamisole. This drug is effective against hookworms, nekators, toxoplases, roundworms, Acinidae, whipworms, trichostrongilides and pinworms.
- "Piperazine" is a medicine based on piperazine adipate. Active only against roundworms and pinworms.
- "Pyrvinium" - a medication with the active substance pyrvinium embonate, is used only in the treatment of pinworms.
- Telmox 100 The active substance is mebendazole. It is a very effective medication against pinworms, hookworms, roundworms, necators, echinococci, eel of intestines, pork chains.
- "Mendamin" - a medicine based on the active substance carbendacim. It is active against roundworms, pinworms, whipworms, hookworms, Acinidae intestines and Necatoria.
When prescribing any of the medicines described above, it must be taken into account that they have high toxicity and a huge list of side effects, including meningeal syndrome, leukopenia, pancytopenia, thrombocytopenia, aplastic anemia, neutropenia, eosinophilia, hypercreatinemia, agranulocytosis, increased blood pressure, hemorrhage, , cylindruria, hepatitis, impaired renal function, baldness, erythema, Johnson-Stevens syndrome, angioedema.
In the instructions for use with Pirantel tablets, the cost is not indicated.
Price
The cost of this drug is very low, varies from 20 to 25 rubles per package. It depends on the region and the pharmacy network.
Reviews about the drug
The reviews of the Pirantel medical device contain a huge amount of diverse information, which is very contradictory.
Judging by the positive reviews, this drug (due to its long existence in the market of pharmacological products) is a time-tested medicine for helminthiasis. Patients note that Pirantel quickly eliminates worms, eliminates the symptoms of the disease and the unpleasant sensations associated with it. Patients are pleased that this medication can be used not only for adults, but also for children. At the same time, the suspension product has a very pleasant smell and taste, which makes it possible to give it even to the smallest children. They take it with pleasure.
Another category of patients who left negative reviews about the drug “Pirantel”, believe that this drug is already outdated, so newer, modern medications should be prescribed. This group of people reports that helminths have acquired resistance to the active substance, so the drug is not effective. However, this is an exclusively subjective opinion; scientific research has not been proven. In addition, negative reviews contain information about a variety of side effects that occurred in people of different ages from some body systems and organs. Among them, severe nausea, dyspeptic symptoms, severe diarrhea most often occurred. Less commonly observed were excessive weakness, dizziness, and decreased attention.
Experts say that this drug has an active effect, but before using it, you should consult a doctor.
The article was presented instructions for the use of "Pirantel."