In the article, we consider the instructions for use with PC-Merz, reviews and analogues.
The drug is an antiparkinsonian drug, which is made on the basis of the active element - amantadine sulfate. Forms of release - tablets and solution for infusion.
Description
This medicinal product stimulates the release of dopamine from neuronal depots, significantly increases the sensitivity of dopaminergic receptors to this substance, due to which, even with a decrease in the level of dopamine production, optimal conditions are created for stabilization of neurophysiological processes in the structures of the basal ganglia. In addition, amantadine has a slowing effect on the generation of nerve impulses in the motor neurons of the central nervous system. At therapeutic concentrations, this drug inhibits the production of acetylcholine, providing a pronounced anticholinergic effect.
In what cases is the use of PC-Merz indicated?
Indications for use
This pharmacological drug is prescribed in the following cases:
- parkinsonism and Parkinson's disease of various etiologies;
- pain and residual symptoms after stereotactic surgical procedures;
- life-threatening and severe cases of parkinsonism (akinetic crisis);
- loss of consciousness or fainting during traumatic brain injuries;
- slowing the patient's exit from anesthesia;
- neuralgic pathologies with shingles.
This is confirmed by the instruction to PC-Merz. Reviews about this drug are presented at the end of the article.
Contraindications
Absolute contraindications to the use of this medication are:
- severe forms of congestive heart failure;
- cardiomyopathy;
- atrioventricular block 2 or stages;
- myocarditis;
- bradycardia;
- ventricular arrhythmias;
- low content of magnesium and potassium in the blood;
- combined use with medications that extend the QT interval;
- prostate adenoma;
- glaucoma;
- psychomotor agitation;
- epilepsy;
- psychosis;
- thyrotoxicosis;
- liver disease (chronic or acute);
- lactase deficiency;
- renal failure;
- lactation, pregnancy;
- age less than 18 years;
- high sensitivity to the components of the drug.
This must be considered before the appointment.
Instruction for use
The drug "PK-Merz" in tablet form should be taken after meals. The first 3 days - 1 tablet per day, then - 2 tablets. In the future, the dosage can be increased - per week by 1 tablet. With combined treatment, the dosage of the drug is prescribed individually. The highest dose per day is 600 mg. The last tablet of the drug is recommended to be taken no later than 16:00.
This medicine in the form of solutions for infusion is administered intravenously 1-2 times a day (if necessary 3 times) in 500 ml. The duration of the infusion is 3 hours. The approximate duration of therapy with this form of medication is 1 week, after which it is recommended that the switch to a tablet dosage form.
Analogs "PC-Merz"
Analogues of the PK-Merz medical product are the following drugs:
- Neomidantan
- Midantan
- Amantine;
- Pronoran;
- Madopar
- Yumex.
A doctor should select a replacement.
Neomidantan
The medication “Neomidantan” is a dopaminergic, antiparkinsonian drug, an analogue of “PK-Merz”. It is effective in bradykinetic and rigid forms of parkinsonism: it increases mobility and activity, reduces muscle tone. To a lesser extent affects tremor. Amantadine (the active element) blocks NMDA glutamate receptors, acts as a dopaminergic substance, promotes the release of dopamine from neuronal depots and increases the sensitivity of dopaminergic receptors to it.
In addition, this medicine has an antiviral effect, inhibits the penetration of the virion into the cell and the release of viral genetic material.
It is well absorbed in the digestive system, the maximum plasma level is reached after about 4 hours.
Indications for the use of the drug "Neomidantan" are: parkinsonism (including due to the use of certain drugs), Parkinson's disease, postherpetic neuralgia, prevention and early treatment of influenza type A.
This medication should be taken orally after a meal. This medication is made in capsules, which are swallowed whole and washed down with water. In Parkinson's disease: 100 mg per day, 1 week after the start of therapy, the dose is increased to 100 mg 2 times a day, usually in combination with other anti-Parkinsonian medications. The interval between doses is at least 6 hours. During treatment, addiction can develop, so after a while it is necessary to increase the dosage. The maximum dose per day is 400 mg. For people with kidney failure and in old age, the dose is reduced.
Let us consider other analogues of PC-Merz.
Midantan
The drug "Midantan" is an antiparkinsonian substance that belongs to the category of symmetric tricyclic adamantamines. The drug is a blocker of glutamate NMDA receptors (including those localized in the substantia nigra), which reduces the excessive stimulating effect on the neostriatum of cortical glutamate neurons, which in most cases is accompanied by insufficient production of dopamine. In addition, this drug element reduces the intake of Ca2 + ions into neurons, reducing the likelihood of their destruction. The drug "Midantan" has an anticholinergic property.
This pharmacological agent is prescribed in the following cases:
- parkinsonism and Parkinson's disease of various etiologies;
- pain and residual symptoms after stereotactic interventions;
- life-threatening and severe cases of parkinsonism (akinetic crisis);
- syncope with traumatic brain injury;
- slowing down the process of removing the patient from anesthesia;
- neuralgic pathologies with shingles.
Contraindications to the use of this medication are: severe forms of congestive heart failure, cardiomyopathy, atrioventricular block, myocarditis, bradycardia, ventricular arrhythmia, low levels of magnesium and potassium in the blood, in combination with medications that extend the QT interval, prostate adenoma, glaucoma, agitation, epilepsy, psychosis.
What other analogues of PC-Merz can be found on sale?
Amantine
The medicine "Amantin" is a dopaminergic, antiparkinsonian drug. It is effective in bradykinetic and rigid forms of parkinsonism: it increases mobility and activity, reduces muscle tone. To a lesser extent affects tremor. Amantadine (the active element) blocks NMDA glutamate receptors, acts as a dopaminergic substance, promotes the release of dopamine from neuronal depots and increases the sensitivity of dopaminergic receptors to it.
In addition, this medicine has an antiviral effect, inhibits the penetration of the virion into the cell and the release of viral genetic material.
It is well absorbed in the digestive system, the maximum plasma level is reached, usually after 4 hours.
Indications for the use of the pharmacological agent "Amantin" are: parkinsonism (including due to the use of certain drugs), Parkinson's disease, postherpetic neuralgia, prevention and early treatment of influenza type A.
This is stated in the instructions for use with the PC-Merz analogue.
This pharmacological agent should be taken orally after a meal. The drug is available in capsules, which are swallowed whole, washed down with water. In Parkinson's disease: 100 mg per day, 1 week after the start of therapy, the dose is increased to 100 mg 2 times a day, usually in combination with other anti-Parkinsonian medications. The interval between doses is at least 6 hours. During treatment, addiction can develop, so after a while it is necessary to increase the dosage. The maximum dose per day is 400 mg. In patients with renal failure and in old age, the dose is reduced.
Reviews about "PC-Merz"
Patients who left reviews about the drug and its analogues note that these medications are quite effective in the treatment of Parkinson's disease. However, as the patients indicate, during therapy it is very important to choose the right dosage and develop a treatment regimen, since such medicines are gradually addictive and cease to have a therapeutic effect. Only a qualified specialist can help. With proper use, the drug relieves the symptoms of the disease well, significantly facilitates the course of the pathological process, improves well-being.
It is better to familiarize yourself with the reviews on the use of PC-Merz in advance.
As for adverse reactions, there are quite a lot of them. Patients who were prescribed such drugs, in most cases, observed such side effects as severe dizziness at the initial stage of therapy. In some cases, there was a headache, dyspeptic disorders.
We reviewed the instructions and analogues to the "PC-Merz".