Among all urological pathologies, it is prostatitis that occupies a leading position. According to statistics, over the past few years, this disease was diagnosed in 43% of males of working age. Alpha-blockers with prostatitis of any form make it possible to avoid surgery if urination is impaired, which develops due to spasm of the urethra and bladder muscles. This is a new generation of drugs that affect receptors that control the contraction of muscles and blood vessels, restoring their activity.
Characteristics of this group of drugs
Alpha-blockers for prostate prostate are used quite often. They are drugs that bind in the body to alpha-adrenergic receptors in the cell walls, preventing them from entering into a relationship with adrenaline and norepinephrine. The use of these funds is a prerequisite for the treatment of prostatitis. They enhance the effect of other medicines, increase muscle tone in the bladder, relax smooth muscles, eliminate the negative symptoms of pathology.
Action of medicines
Prostatitis is a disease of the prostate gland, in which pressure increases as a result of closing the urethra, urination is disrupted, the urinary canals are not fully opened, muscle tone in the bladder decreases, and negative symptoms develop. At the same time, the reproductive system suffers. Urethral obstruction leads to the development of an inflammatory process in the prostate; urine refluxes into its ducts.
In this case, alpha-blockers are used for prostatitis. Drugs from this group contribute to the normalization of the closing pressure of the urethra, urination and the activity of the urinary system. Thanks to them, it is possible to eliminate the negative symptoms of the disease.
Many patients are wondering if these are alpha blockers for prostatitis. These drugs block adrenergic receptors, which are spasmodic and vasoconstrictive. When they are blocked, the opposite effect is observed - antispasmodic and vasodilator.
Drug groups
There are several groups of alpha blockers in the treatment of prostatitis that are used. These include:
- Non-selective, which includes phentolamine and phenoxybenzamine. The action of these funds applies to all adrenergic receptors.
- Alpha 1-blockers that act selectively. They may include indoramine, prazosin, doxazosin or alfuzosin.
- Alpha 2-blockers also have a selective effect. This group includes only one drug from alpha blockers for prostatitis - Yohimbine.
After making a diagnosis, the attending doctor will prescribe exactly the remedy that is best suited in each particular case.
Alpha-blockers for prostatitis: mechanism of action
Selective (selective) alpha-blockers in this disease contribute to the normalization of blood circulation in the prostate, reduce smooth muscle spasms, and reduce pressure on the urethra. This leads to an easier urination process, an increase in the urine flow rate. Yes, according to medical statistics, it is precisely these groups of drugs that reduce the incidence of relapses. Such medications selectively affect receptors, but do not affect the muscle tone of the bladder.
Non-selective (non-selective) alpha blockers for prostatitis often lead to bladder weakness. This is their side effect.
That is why many doctors recommend the use of selective alpha-blockers in therapy. The list of drugs for prostatitis, which is often prescribed by doctors, includes the following tools:
- Non-selective: Pyrroxan, Sermion, Phentolamine.
- Selective: Prazosin, Terazozin, Tamsulosin, Doxazosin, Alfuzosin.
Application restrictions
Contraindications to the use of alpha-blockers for prostatitis are:
- Highly low blood pressure.
- Fainting conditions.
- High susceptibility to the components of medicines.
- Sharing of other adrenergic blockers.
- Acute liver disease.
- Atherosclerosis.
- Age over 75 years.
Selective alpha-blockers for prostatitis: a list of drugs and features of use
Most often, doctors prescribe selective adrenoblockers to their patients. The most common are the following:
- "Tamsulosin" is the most effective medication in the treatment of prostatitis. Its action is directed to muscle groups of the prostate. A positive result can be observed already on the tenth day of treatment. It is produced in the form of tablets and capsules, used once in a daily dosage of 400 mg. This drug relieves pain, normalizes the outflow of urine, the process of urination. This medication can cause the development of adverse reactions such as lowering blood pressure, weakness, impaired attention. Such phenomena pass independently after the end of the course of therapy.
- "Doxazosin" is a selective alpha-blocker, with prostatitis it is often prescribed. Its intake begins with a minimum dosage (1 mg), gradually increasing it to 16 mg per day. The medicine is taken twice a day before meals. In each case, the doctor sets the duration of therapy. You can not use it with low blood pressure, liver disease and allergies. This medication can provoke such adverse reactions as impaired vision, breathing, dry mouth, swelling, nosebleeds.
- "Terazosin" - tablets for prostatitis, which are taken once a day in the evening. A positive result is noticeable already in the second week of therapy. And its duration is one and a half months. It is necessary to begin treatment with a minimum dosage (1 mg), gradually increasing it to 20 mg per day. The treatment regimen will be the attending doctor. You can not use the medicine for pathologies of the heart and circulatory system, liver and kidneys, as well as in the presence of diabetes mellitus. In the course of therapy, such adverse reactions as swelling, impaired vision and sexual function can develop.
- "Alfuzosin" is a drug that is rarely used, as it can lead to complications if it is used simultaneously with other drugs. It is available in the form of tablets that are drunk once a day in a dosage of 5 or 10 mg. You can not use it in the presence of low blood pressure and allergies. Side effects include weakness, dizziness, headache, tremor of the extremities, drowsiness.
List of non-selective blockers
Non-selective alpha blockers, which are usually prescribed, include:
- Phentolamine is available in the form of tablets and an injection. It is used in an amount of 2 to 5 mg per day. You can not use this medicine for severe pathologies of the cardiovascular system. Side effects include tachycardia, flushing of the skin, dizziness, nausea, a sharp drop in blood pressure.
- "Sermion" - a drug produced in the form of a solution for injection and tablets. Take the medicine three times a day in a dosage of 5 or 10 mg. The course of therapy is about eight weeks. The medication is contraindicated with high susceptibility to the components of the drug, angina pectoris, low blood pressure, bradycardia. It can also cause the development of adverse reactions such as hypotension, weakness, drowsiness, allergies, cold extremities.
- “Pyroxan” is in the form of tablets and a solution for injections. Take one or two pills three times a day. During therapy, bradycardia may develop, blood pressure may decrease. You can not use the medication for atherosclerosis, ischemia, circulatory disorders in the brain, heart failure.
Reviews of doctors
According to medical reviews, alpha-blockers for prostatitis are effective and efficient. Each of these drugs has its own characteristics, which are taken into account when developing a treatment regimen for each individual patient. Such agents, when used in complex therapy, eliminate the negative symptoms of the disease, and contribute to the normalization of urine outflow. With their regular use, a persistent therapeutic effect is observed.
Patient Reviews
According to numerous reviews, it is Doxazosin that is one of the most effective medicines in the treatment of this disease. For a short period of time, it eliminates negative symptoms, normalizes the process of urination.
The reviews confirm that Alfuzosin has a milder effect, it is used for the treatment of chronic prostatitis. And "Terazosin" practically does not provoke the development of adverse reactions.
But the most effective and popular drug for prostatitis is Tamsulosin. It is considered to be the best in its pharmacological group.
The benefits of therapy
These medicines have several advantages. They also have a pronounced therapeutic effect, which can be seen in the following:
- Elimination of acute symptoms of the disease.
- Pressure reduction when closing the urethra.
- Increased urine flow rate during urination.
- Reducing the frequency of relapses in the chronic form of the disease.
Alpha-blockers are used in both acute and chronic prostatitis. They are included in the complex treatment of pathology. If you use only such drugs and no others, then the treatment will be symptomatic, since they eliminate the negative signs of the disease only for a while.
Today, a large number of different medicines for the treatment of prostatitis are presented on the pharmacology market. The doctor will select exactly the drug that is best suited.
Conclusion
The choice of drugs for prostatitis should be carried out by the attending doctor. When developing a treatment regimen, it takes into account the results of analyzes, the features of the course and form of the disease, the individual characteristics of the patient's body. Self-medication is not recommended. Uncontrolled use of alpha-blockers can provoke the development of complications.
Alpha-adrenergic blockers are the most effective medications that are used in urology for the treatment of prostatitis. They have an effective effect on the receptors of the bladder and urethra, eliminate their spasm and tension. This leads to the normalization of the outflow of urine, eliminates congestion in the genitourinary system.