The medicine "Eglonil" is intended for the treatment of a wide range of pathologies of the nervous system. This is an antipsychotic, which can only be prescribed by a doctor. At the reception, the doctor will tell you why Eglonil helps, why it is useful in a particular case, how to take it correctly. If there is a need to replace the drug with an analogue, you can not choose alternative medicines on your own, you must consult your doctor. The drug may be ineffective, provoke severe adverse reactions. There are several Eglonil analogues on sale, so be sure to ask a specialist which is better to choose.
What is this about?
Eglonil is built on sulpiride, the effectiveness of which is enhanced by the addition of additional components. Excipients are introduced into the drug to minimize the occurrence of adverse reactions. On sale there are tablets, Eglonil capsules, a solution intended for injection.
Capsules are coated with a gelatin shell, painted in gray-yellow color, the consistency is solid. Inside the shell is a yellowish powder. One package contains 15 or 30 pieces of capsules. The tablets are also painted in a yellowish tint, each has a simplifying risk sharing. The package contains 12-60 pcs. Eglonil ampoules with injection are filled with a colorless liquid. The medicine is odorless. Sold in pharmacies.
How it works?
In any form (Egonil injections, tablets and capsules), the drug shows the same pharmacokinetic qualities. It belongs to the group of antipsychotics of moderate effectiveness, selectively inhibits dopamine receptors. The advantage of using ampoules, tablets, injections "Eglonil" in the absence of a pronounced sedative effect. The drug is prescribed as an antidepressant and stimulant.
Like many drugs from the list of antipsychotics, Eglonil helps to eliminate hallucinations, fears, increase tone, reduce anhedonia. When used in a large dosage, a sedative effect is observed.
Application features
Eglonil (50 mg and a different dosage) for oral use is effective after five hours, injectively after 30 minutes. The active component is practically not metabolized, excreted through the kidneys. The half-life is about seven hours.
Cancellation of Eglonil requires medical supervision, since negative symptoms are possible a week after the cessation of systematic administration. Often, exacerbations of symptoms are observed. To prevent a severe reaction, constant consultation with a specialist is required.
When is it prescribed?
For neuroleptic drugs, the list of indications is quite wide, and Eglonil will not be an exception. It can be used for delusional states, hallucinations and confused consciousness, psychosis and lethargy. The effectiveness of the drug shows with abulia, agramatism, schizophrenia in sluggish form. Often "Eglonil" is prescribed for psychosomatic pathologies, neurotic disorders.
Additionally, Eglonil is used in a therapeutic program to eliminate gastric and intestinal ulcers.
Contraindications
Like many Eglonil analogues, the drug cannot be taken with an allergic reaction to the active component of sulpiride. It is forbidden to prescribe a remedy if hypersensitivity to any additional substance in the composition is detected. Eglonil is not used in the treatment of patients diagnosed with pheochromocytoma.
What to change?
Many analogues of Eglonil are on sale. Some are built on the same active substance. A doctor may advise other similar medicines to the patient if sulpiride intolerance is detected. In practice, it is customary to resort to one of the tools from the following list:
- "Sulpiride Belupo."
- Tiaprilan.
- Tiaprid.
- "Prosulpin."
- Soleron.
Often, doctors suggest replacing the medication with Restful, Sulpirid-ZN.
Well-known analogues of Eglonila are Tiaprosan, Tiapridal, and Betamax. In some cases, it is recommended to use the drug "Solian".
"Sulpiride Belupo"
This medicine includes sulpiride, therefore, shows efficacy in a wide range of pathologies: unspecified delirium, schizophrenic, depression, recurrent disorders. The drug is effective for irritable bowel syndrome. At the same time, it belongs to the category of both antipsychotics and antiemetic drugs. It can be used by itself, as well as as an element of complex therapy. Often they resort to it with acute delirium, depression disorders.
Sold in tablets of 50 or 200 mg. The drug is packaged in bottles or blisters, as many as contained inside the tablets are indicated on the cardboard packaging.
Indications
"Sulpiride Belupo" is a modern analogue of "Eglonil", which has a pronounced atypical antipsychotic effect. Fights depression, vomiting, weakness. The active substance in the human body inhibits the activity of dopamine receptors, affects the limbic system. However, studies have shown that the effect on the neostriatal system is very weak, so it can be completely ignored if a small dosage is prescribed.
The antipsychotic effect is observed when taking sulpiride in a daily dose of 600 mg or more. A lower dosage is prescribed for depression, as well as in the treatment of diseases of the nervous system, where you need to use the compound as a stimulant. As clinical trials have shown, there is no significant effect on the GABA, histamine, and serotonin receptors. Sulpiride practically does not correct the work of cholinergic, adrenergic receptors.
Specifics of use
In a small dose, “Sulpiride Belupo” shows a good result as an auxiliary component in the treatment of psychosomatic pathologies. You can resort to it if specific symptoms have been identified that accompany a gastric, intestinal ulcer. If the colon is irritated, “Sulpiride Belupo” helps reduce abdominal pain, so that the clinical condition is stabilized and the patient feels better.
At a daily dose of 50 to 300 mg, “Sulpiride Belupo” eliminates dizziness, the cause of this condition does not play a role. Taking the medication has a depressing effect on the prolactin-producing tissues, at the same time there is an effect on the vomiting center.
What is going on in the body?
The bioavailability of the drug is about 27%. Less than 40% of compounds form bonds with blood proteins. In the central nervous system, sulpiride is detected in a concentration not exceeding five percent of the amount observed in plasma. The substance is not subject to metabolic processes, it is excreted almost unchanged through the urinary system. The elimination half-life is up to eight hours.
In case of impaired renal function in a moderate and severe degree, the half-life period increases significantly, which forces to adjust the dosage and increase the intake intervals.
Betamax
This analogue of Eglonil can rightly be considered one of the most used in modern medical practice. Available in tablets, the concentration of the active compound is 50, 100, 200 mg. The main therapeutic effect of the intake is due to the amount of sulpiride, but each tablet contains a number of auxiliary components that simplify the administration of the drug and improve its digestibility.
The medication belongs to the group of antidepressants, antipsychotics of the atypical class. Prevents gag reflex, stimulates and eliminates depressive disorders. At a normal dosage, it does not provoke a sedative effect. Antipsychotic effects are due to inhibition of 2D dopamine receptors. To obtain such a result, you need to use from 600 mg of sulpiride or more daily. In depressive disorders, the drug is prescribed in a lower dosage, taking into account the individual characteristics of the patient.
About the medicine
Prevention of gag reflex is due to blocking of 2D dopamine receptors. The use in the treatment of peptic ulcer is associated with the ability to reduce the excitability of the sympathetic nervous system. At the same time, the production of gastric mucus is activated, blood flow improves, regenerative processes are initiated, so that defects caused by an ulcer heal faster.
The use of Betamax is accompanied by an increase in the activity of prolactin production. Clinical trials have shown that the drug does not affect the histamine, serotonin, adrenergic, and cholinergic receptors.
Admission Rules, Indications
"Betamax" is intended for oral administration, the highest concentration in the blood is formed three hours after application. Bioavailability is within 27%, blood protein binding is not more than 40%. The drug is not subject to metabolic processes, excreted by the kidneys. When treating patients who are diagnosed with renal failure, it should be borne in mind that the half-life is increased to 26 hours. It is known that the active ingredient can pass into breast milk.
Betamax is used for the treatment of delirium, schizophrenia in various forms, depressive, neurotic disorders. The tool can be used as an adjunct in ulcers, irritable bowel syndrome. "Betamax" effectively eliminates dizziness of a different nature, including those provoked by injuries, neuritis, otitis media, Meniere's disease. "Betamax" is effective for migraines, hallucinations. It is also prescribed for chronic alcoholism, as well as to normalize the psychological background after serious illness.
When is it impossible?
The medicine does not have a positive effect in case of psychosis of the manic type, aggressiveness, affective disorders, poisoning with alcohol, sleeping pills, opioids. You can not resort to this medicine if a history of convulsive seizures, tumor processes dependent on prolactin are present. Betamax is not intended for the treatment of patients diagnosed with Parkinson's disease, severe hypertension, pheochromocytoma. It is unacceptable to use the drug for hyperprolactinemia. Usually it is not prescribed for minors, they are not used during lactation, pregnancy, and also with hypersensitivity to any component of the medication.
Unpleasant consequences
Reception "Betamax" can provoke some side effects, which include sedation, sleep problems, excited state, drowsiness and dizziness. There are known cases of increased pressure, dry mucous membranes, gastrointestinal problems, including heartburn. In women, with the use of Betamax, menstrual irregularities are sometimes observed. Allergic reactions can occur with skin rashes, itching. In some patients with Betamax therapy, swelling, sweating, hyperthermia, and a sharp increase in weight were recorded.