The medicine "Metromicon-Neo" is a drug that has an antiprotozoal, antibacterial and antifungal effect. It is used to treat various gynecological diseases.
Description and form of release
The drug is available in the form of suppositories in white, the color may also have a yellow tinge. Candles have a cylindrical shape, which resembles a small torpedo. A porous rod with a funnel-shaped recess may be located on the cut. The main active ingredient is metronidazole, one suppository includes 500 mg of this active substance, as well as 100 mg of miconazole. Also, the composition of the drug also includes adjuvants, such as semi-synthetic glycerides, which are used to achieve a suppository mass of 2000 mg. Candles are in contour packs of two blisters in a cardboard bundle. In total, the package can count 14 candles.
pharmachologic effect
"Metromicon-Neo" is a drug that has a bactericidal type of action, it is capable of interacting with deoxyribonucleic acid. The main substance biochemically restores the 5-nitro group, which inhibits the synthesis of nucleic acids, thereby killing bacteria. This drug is highly active against the simplest and most obligate anaerobic bacteria: Entamoeba, Trichomonas vaginalis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Veillonella spp, Prevotella, Mobiluncus, Gardnerella vaginalis.
The second active substance - miconazole - has an antifungal effect. During intravaginal administration, the drug is active against Candida albicans. Miconazole has a fungistatic and fungicidal effect, thereby inhibiting the plasma membranes of fungi and the biosynthesis of ergosterol shell. By changing the lipid composition, the active substance causes the death of the fungal cell.
Pharmacokinetics
In contrast to oral administration, with intravaginal administration, the bioavailability of metronidazole is 20%. The half-life of active substances from the body occurs in 6-10 hours. Approximately 20% of the main dose is excreted unchanged with urine. Miconazole during intravaginal administration is slightly absorbed, therefore, is not detected in blood plasma.
Indications for use
For the use of the drug "Metromicon-Neo" the instruction defines such indications:
- Trichomonas vaginitis;
- vaginal candidiasis;
- bacterial vaginosis;
- vulvovaginitis;
- mixed vaginal infections.
Contraindications
This drug has a fairly small number of contraindications. Virgins, first of all, should not take Metromicon-Neo. The instruction also highlights other contraindications. For example, it is forbidden to use the drug for women who breastfeed the baby, as well as for pregnant women during the first trimester. It is forbidden to use the drug for girls who have not reached the age of majority (who are not 18 years old). You should not take the drug in those patients who have hypersensitivity to the individual components of this drug.
The drug should be taken with caution in people with hepatic and renal insufficiency, as well as in diabetes mellitus, porphyria, with impaired microcirculation and impaired hematopoiesis. In the second and third trimester of pregnancy, as well as in diseases of the nervous system, Metromicon-Neo should also be used carefully.
Drug use
The drug is introduced into the body intravaginally. For use, you need to release the suppository with scissors, cutting the film along the contour, and then enter the opened candle as deep as possible into the vagina. In acute vaginitis or bacterial vaginosis, the drug is used for a week. Use the drug 2 times a day for 1 candle in the morning and evening.
During chronic vaginitis, Metromicon-Neo (candles) should be used for two weeks, 1 suppository per night. In relapses of vaginitis, in the treatment by other means or in the absence of positive clinical dynamics, suppositories are used 2 times a day. It is necessary to apply suppositories 1 piece each morning and evening for two weeks.
Adverse reactions
Quite different side effects can occur if you use Metromicon-Neo (candles). Instructions for use indicate several side effects. From local reactions, itching, burning and irritation on the mucous membrane of the vagina can be observed, swelling can also occur. With vaginitis, due to inflammation of the mucosa, after the first injection of a suppository, irritation can intensify. Also, increased irritation can be observed after the third day of treatment. To remove these symptoms, it is necessary to stop treatment.
In addition, gastrointestinal symptoms may be observed. This can be constipation or diarrhea, cramping or abdominal pain, nausea or vomiting, as well as dry and metallic taste in the mouth.
Regarding the central nervous system, dizziness or headaches, cramps, psycho-emotional and motor disorders are possible. Skin reactions (eg, rash, itching, urticaria) are also possible.
Drug overdose
If Metromicon-Neo (candles) is used in the doses recommended by the instructions, there should not be an overdose, since the drug has a low absorption. But when using the drug in large doses, symptoms such as abdominal pain, vomiting, nausea, diarrhea are possible. As well as dizziness, ataxia, dry mouth, paresthesia, dark urine, cramps. When using a high dose of the drug for a long time, peripheral neuropathy is possible. To get rid of the symptoms of an overdose, symptomatic treatment is needed. If the drug was taken orally under any circumstances, urgent gastric lavage is necessary.
Special instructions
It should be noted that when using the drug "Metromicon-Neo", you should refrain from sexual intercourse. To avoid re-infection, simultaneous therapy of the sexual partner is necessary. When using the drug, as well as a couple of days after the cessation of use, it is necessary to exclude the intake of ethanol, since its intolerance is possible.
In case of severe irritation, it is necessary to stop treatment with Metromikon-Neo. Reviews of patients show that irritation appears relatively often, in which case the drug must be replaced. Suppositories should be used intravaginally, use in any other way is prohibited.
The drug has a negligible effect on driving, but if you experience any side effects, such as dizziness, you should avoid working with mechanisms and do not drive a car.
Storage
The drug should be stored in the dark at room temperature. Keep out of reach of children. The shelf life of the drug is 36 months, after its completion the drug is prohibited.
Cost "Metromicon-Neo"
The price of this drug depends on several factors, primarily on the country in which the goods are produced and the transportation distance to individual points of sale. On average, the price ranges from 350 to 550 rubles. The price is considered low, since in one package there are 14 suppositories (for 1 course of treatment).
Patient opinions on the drug "Metromicon-Neo"
Reviews of many women are only positive. Almost everyone is happy with this drug. This tool, although it is an analogue of a more expensive one, but fully justifies itself. Symptoms of vaginal diseases disappear after 2 days, this is very pleasing to patients.
Many girls warn that when using this medication it is necessary to use daily pads, since suppositories leak from the vagina during the day. There were also negative reviews from people who used Metromicon-Neo (candles). The price, they said, is affordable, but it doesn’t quite heal. They also add that the drug only relieves the symptoms, but does not provide any treatment, so the infection is constantly in the body and from time to time occurs again. But it should be noted that such reviews are much less than positive.
In any case, before use, consultation with a doctor and an accurate determination of the diagnosis are necessary, since when using the drug on its own, it can not only not act, but also harm the body.