Vascular thrombosis leads to the development of serious diseases that are dangerous to human life. Almost all patients at risk are shown taking acetylsalicylic acid-based drugs as a prophylaxis of the disease. The drug “Thrombo ACC” also has an antiplatelet effect. It belongs to the group of non-steroidal anti-inflammatory drugs. Indications for use of Thrombo ACC, the recommended dosage and treatment regimen are described in detail by the manufacturer in the instructions. It is imperative that you familiarize yourself with this information before starting treatment.
General description of the drug
"Thrombo ACC" is a representative of non-steroidal anti-inflammatory drugs. These drugs reduce the symptoms of inflammation, which are usually accompanied by many pathological conditions. Despite the popularity of NSAIDs, they should be used with extreme caution. Such treatment is fraught with serious side effects.
For the treatment of cardiovascular disorders, Thrombo ACC is often prescribed. The medicine is manufactured by the Austrian pharmaceutical company "G.L. Pharma, GmbH." The main effect of the drug is aimed at reducing platelet aggregation, reducing the formation of blood clots, relieving the inflammatory process and pain relief.
"Trombo ASS": composition and form of release
Before using the medication, the patient must familiarize himself with the components that make up the composition. The main active ingredient is acetylsalicylic acid, popularly known as aspirin. Thrombo ACC is available in the form of tablets coated with a special film coating. It provides protection of the gastric mucosa from the negative effects of acetylsalicylic acid and dissolves only in the intestine. One such tablet contains 50, 75 or 100 mg of active ingredient.
As auxiliary components, silicon dioxide colloidal, lactose monohydrate, potato starch, microcrystalline cellulose are used.
Mechanism of action
Acetylsalicylic acid has long been known in medicine and is used for the manufacture of various drugs. The substance provides an anti-inflammatory effect due to the selective blocking of the functions of COX 1 (cyclooxygenase enzyme). This causes an inhibition of the synthesis of thromboxane, prostaglandins and prostacyclins - substances that provoke the development of the inflammatory process. Platelets cannot form a new enzyme, which allows the antiplatelet effect to manifest itself to a greater extent by reducing their bonding. This allows you to take medicine in small doses.
Acetylsalicylic acid prevents blood coagulation, enhancing its fibrinolytic activity. The substance also provides analgesic and antipyretic effects.
Indications for use
"Thrombo ACC" instruction advises to prescribe for the following diseases:
- prevention of thromboembolism after surgery on the vessels;
- prevention of blood clots in deep veins;
- primary and secondary prevention of cerebral stroke;
- prevention of transient cerebrovascular accident;
- diabetes;
- high blood pressure;
- smoking;
- severe obesity;
- unstable angina pectoris;
- chronic venous insufficiency;
- varicose veins;
- primary and secondary prevention of myocardial infarction;
- hyperlipidemia.
Also, a drug based on acetylsalicylic acid is recommended for all elderly people. Indications for use of "Thrombo ACC" are mainly associated with the prevention of cardiovascular pathologies. Due to the low content of acetylsalicylic acid, tablets can be taken for a long time. The treatment regimen and dosage should be determined by a specialist.
Mode of application
The instructions describe in detail how to take "Thrombo ACC". The manufacturer strongly recommends drinking tablets before meals, but not on an empty stomach. This will help reduce the risk of side effects. Also, tablets are washed down with plenty of water, do not chew and do not share.
Dosage of medication
It should be noted that only a doctor can prescribe a non-steroidal anti-inflammatory drug “Thrombo ACC” for treatment. The dosage of the drug will depend on the diagnosis of the patient. As a prevention of strokes and heart attacks, tablets should be taken for a long time. The daily dosage is 50-100 mg (one or two tablets per day). The same dose is indicated for the prevention of angina pectoris. Patients with the threat of a repeated transient ischemic attack are recommended to take 75-300 mg of acetylsalicylic acid per day.
At a risk of thromboembolism of the pulmonary artery or deep veins, the dosage of the thrombo ACC drug is increased. 100 mg is the minimum dose of the active substance for such patients. According to indications, it can be increased to 200 mg per day. The medicine can not be taken simultaneously with other medicines from the NSAID group. The duration of therapy is determined individually.
In what cases is it forbidden to take medicine?
The diluting properties of acetylsalicylic acid are indeed important in some cases. But on the other hand, such a therapeutic effect poses a serious threat to life if the patient has at least one of the following diseases:
- erosion and ulcers of the gastrointestinal tract;
- hemorrhagic diathesis;
- bronchial asthma;
- age up to 16 years;
- intolerance to acetylsalicylic acid;
- internal bleeding;
- acute renal or liver failure;
- lactose intolerance ;
- chronic heart failure;
- intolerance to other non-steroidal anti-inflammatory drugs;
- recurrent hay fever in combination with bronchial asthma and aspirin intolerance.
The drug is prohibited for women who suffer from heavy blood loss during menstruation. With extreme caution, tablets are prescribed to patients who have a history of chronic respiratory diseases.
Taking the drug during pregnancy
In the process of researching the drug, no relationship was found between congenital malformations and the use of Thrombo ACC. However, experts recommend that you refrain from taking pills in the first and third trimester. Exceptions are cases in which the expected benefit to the mother is greater than the risk of developing congenital pathologies. Only the attending physician can prescribe a medicine to thin the blood for the expectant mother.
If necessary, a medication can be prescribed after childbirth. An insignificant dose of acetylsalicylic acid contained in Trombo ACC tablets (50 mg) does not adversely affect lactation. If long-term therapy is needed, breastfeeding should be discontinued or interrupted.
Features of the use of the drug
Inhibitory properties persist for several days, which can cause bleeding during surgery or during the recovery period. Therefore, you should refrain from taking tablets before surgery.
Hematopoietic organs significantly increase the risk of side effects while taking Methotrexate and Thrombo ACC (the price of the drug depends on the dosage of the active component). High doses of acetylsalicylic acid have a hypoglycemic effect. This should be considered in patients with diabetes receiving insulin and hypoglycemic medications for oral use.
It is not recommended to combine ibuprofen with acetylsalicylic acid. The first has a negative effect on the cardioprotective effect of aspirin, which can have serious consequences for patients with cardiovascular diseases.
Persons with a predisposition to gout should avoid drugs based on acetylsalicylic acid. "Thrombo ACC" (tablets), the instruction does not recommend taking at the same time as anticoagulants, antiplatelet drugs and thrombolytics. Such therapy increases the risk of bleeding.
With simultaneous treatment with valproic acid, aspirin increases its toxic effect. It is not recommended to take "Thrombo ACC" in combination with corticosteroids to avoid gastrointestinal bleeding.
Side effects
The first thing that the patient studies when prescribing a new drug to him is indications for use. “Thrombo ACC” should be taken only on the recommendation of a doctor, because this medicine, despite all its positive properties, has quite serious consequences associated with improper administration.
The drug is generally well tolerated, only in rare cases, side effects are recorded. From the gastrointestinal tract, disorders such as pain in the epigastric region, heartburn, vomiting, nausea, ulcerative lesions of the mucous membrane of the digestive tract can occur.
The use of acetylsalicylic acid is fraught with the development of nosebleeds, hemorrhage of the gastrointestinal tract. In patients with arterial hypertension, cerebral hemorrhage may occur.
Bleeding can lead to iron deficiency anemia (acute or chronic). The pathological condition is usually detected in the process of laboratory blood tests. Characteristic signs are: pallor of the skin, weakness, dizziness, asthenia.
With increased sensitivity or intolerance to acetylsalicylic acid, an allergic reaction in the form of urticaria, redness of the skin, itching, swelling may occur. Severe allergic reactions - anaphylactic shock, bronchospasm, Quincke's edema - are extremely rare.
Overdose
If you follow the recommendations regarding taking the medicine, an overdose is unlikely. If the dose taken is much higher than the measure, symptoms such as tinnitus, nausea, dizziness, vomiting, and confusion may appear. In old age, an overdose of aspirin is fraught with serious consequences.
If symptoms of an overdose occur, the patient should be hospitalized. In the hospital mode, emergency therapy will be carried out: restoration of water-electrolyte balance, forced alkaline diuresis, gastric lavage.
How to replace the drug?
If necessary, you can replace the drug "Thrombo ACC." Analogs, the price of which is slightly different from the cost of the original product, have their own characteristics of application. Therefore, it is not recommended to replace the medicine without consulting a doctor. The following medicines have a similar composition and therapeutic effect:
- "Aspirin Cardio."
- "Aspecard."
- Cardiomagnyl.
- Lospirin.
- "Magnikor."
- "Anopyrine."
- "Polokard".
- "Combi-Ask."
Many patients believe that the remedy can be replaced with conventional aspirin. Actually this is not true. “Thrombo ACC” (the price per package is about 60 rubles) does not have such a detrimental effect on the mucous membrane of the stomach and intestines as regular aspirin tablets. A special protective shell significantly reduces the irritating effect of acetylsalicylic acid.
Patient Reviews
The drug "Thrombo ACC" has earned many positive reviews from patients who took it for the treatment or prevention of cardiovascular disorders. Tablets can be taken for a long time without harm to the gastrointestinal tract. The reception schedule prescribed by a specialist is not recommended to be violated. Cases of side effects are extremely rare.