Do proctoglivenol suppositories help? Reviews on the effectiveness of this medication will be presented below. You will also learn about how this drug works, in what cases it is prescribed, how much it costs and whether it has analogues.
Packaging, composition
Candles "Proctoglivenol", the instructions for use of which are contained in a cardboard box, go on sale in blisters of 5 pieces. They are white oblong suppositories for rectal administration and include active ingredients such as tribenoside and lidocaine. Also, this drug contains auxiliary components in the form of Vitepsol E85 and Witepsol W35.
It is impossible not to say that on sale you can find another form of this drug. "Proctoglivenol" is a white, uniform, opaque ointment and having a specific smell. It is available in a 30 g tube and contains similar active ingredients.
Basic properties
The drug "Proctoglivenol", the price of which will be indicated below, is intended for local treatment of hemorrhoids. It contains two active ingredients - lidocaine and tribenoside. Due to their presence, the medication is able to have a venotonic, local anesthetic and anti-inflammatory effect. It also improves microcirculation, reduces pain and the intensity of the inflammatory process.
When using suppositories in recommended dosages, there is a decrease in venous stasis, a decrease in vascular permeability and the elimination of such unpleasant signs of hemorrhoids as pain and itching in the rectum and anus.
Operating principle
The therapeutic effects and mechanism of action of the medication in question are due to the pharmacological characteristics of the active substances that make up its composition.
So how do proctoglivenol suppositories work? Instructions for use states that tribenoside is a synthetic substance belonging to the class of glucofuranosides. The mechanism of its action is not fully understood. However, experts suggest that it is associated with the ability of tribenoside to inhibit the activity of endogenous amines such as histamine, bradykinin and serotonin.
It cannot be said that tribenoside is an antagonist of humoral factors that contribute to the development of edema, vasodilation, increased permeability and inflammation of blood vessels.
In the process of research, it was noted that the drug "Proctoglivenol" (ointment and suppositories) does not affect the activity of endogenous vasoconstrictors, including norepinephrine and epinephrine. This drug eliminates congestion in the veins, and also increases their tone and helps to reduce increased (pathologically) vascular permeability.
Being an antagonist of inflammatory mediators, tribenoside, when used, reduces the intensity of the inflammatory process, has an anti-edematous and analgesic effect. It should also be noted that the substance in question reduces the ability of platelets to adhere.
What role does lidocaine play in Proctoglivenol (the price of this drug is available to everyone)? This element is a local anesthetic substance, which refers to derivatives of acetanilide.
The principle of operation of the said agent is based on its ability to block sodium channels, as a result of which cell membranes are stabilized.
Experts report that lidocaine inhibits well the generation, as well as the conduction of impulses in nerve fibers. At the same time, its overwhelming effect on the conduct of pain impulses and impulses of other modalities is observed.
In the process of local application, the substance in question does not have any effect on the myocardium.
Kinetic characteristics of the drug
Are Proctoglivenol suppositories absorbed? Reviews say that with the introduction of this drug, the rectally bioavailability of tribenoside is approximately 30% of that when using oral forms with the same active substance.
The peak plasma concentration of tribenoside during rectal administration is about 1 μg / ml. This value is reached 2 hours after the introduction of suppositories.
As for Proctoglivenol cream, when it is used, approximately 5-20% of tribenoside enters the systemic bloodstream. The metabolism of tribenoside occurs in the liver, and it is excreted in the form of metabolites mainly by the kidneys.
According to the attached instructions, lidocaine is quite well absorbed when applying the cream to the mucous membranes. It should be noted that after application to intact skin, the absorption of this substance is negligible.
After rectal administration of the suppository, the bioavailability of lidocaine is approximately 50%, and the peak of its plasma concentration is about 0.7 μg / ml (achieved within two hours).
Indications
What are Proctoglivenol suppositories intended for? Reviews report that this tool is actively used for the conservative treatment of external and internal hemorrhoids in people with moderate severity and mild course of the disease.
Also, the drug in question can be used in the treatment of patients with severe hemorrhoids, if for some reason it is not possible to conduct surgery.
Contraindications
Are there Proctoglivenol suppositories? The reviews of experts say that there are few prohibitions on the use of this drug. It is not prescribed only in the following cases:
- in the first trimester of pregnancy;
- with high sensitivity to the elements of the drug;
- children (due to the lack of reliable data on the safety and effectiveness of the medication).
How should I use proctoglivenol suppositories for hemorrhoids?
Reviews of patients report that this medication is effective only if all the recommendations of the doctor are strictly observed.
The drug in question is used rectally. Before introducing it into the anus, wash your hands thoroughly.
The duration of the course of therapy and the dosage of the drug is determined only by the attending physician, individually.
Usually, for adults with the development of acute hemorrhoids, a medication is prescribed 1 suppository twice a day (or 1 ointment application). Therapeutic procedures are carried out in the morning and in the evening, until the acute symptoms disappear completely.
As soon as the clinical picture improves and all the expressed signs of the disease disappear, they switch to using 1 suppository or 1 ointment application once a day.
For adult patients with the development of internal hemorrhoids, the drug in question is also prescribed in the form of a cream or suppository according to the standard scheme. In this case, the ointment is recommended to be injected directly into the rectum using a special applicator.
Negative Actions
The drug from hemorrhoids "Proctoglivenol" is well tolerated by patients. Sometimes, against the background of its use in people, local allergic reactions were noted, including skin itching. Also, in isolated cases, when using the medication, patients complained of a burning sensation in the anus.
The drug "Proctoglivenol" (suppositories) during breastfeeding and during pregnancy
According to the attached instructions, the medication in question can be used during lactation. However, this should be done only as directed by the attending doctor.
Is it possible to use the drug "Proctoglivenol" (suppositories) during pregnancy? This tool is not recommended for use in the first three months of gestation. In the second and third trimester it can be prescribed, but only if the benefit to the mother outweighs the potential risk to the child.
Overdose cases
To date, no reports of an overdose of the drug in question have been reported.
If the drug was accidentally swallowed by the patient, then an urgent gastric lavage is performed, and enterosorbents are also prescribed. If required, then carry out symptomatic therapy.
The cost of the drug, its analogues
How much is it and what can replace the Proctoglivenol medication (suppositories)? Analogs, the price of this drug will be presented right now.
If, for one reason or another, the remedy in question did not suit you, then you can use the following medications for hemorrhoids: Anuzol, Bezornil, Relif Pro, Betiol, Proctosan Neo, Pilex, Proctosed ”,“ Proctan ”,“ Relief ”,“ Hemorron ”,“ Aurobin ”, Belladonna extract,“ Proctosan ”.
As for the price, it can differ for candles and Proctoglivenol cream. As a rule, suppositories cost about 400 rubles, and ointment about 550 rubles.
Reviews on the drug (suppositories and rectal ointment)
Reviews about rectal suppositories are mostly positive. Patients suffering from inflammation of hemorrhoids claim that in just a few days this drug is able to relieve all the unpleasant sensations of itching, burning and pain associated with this disease. Also, the medication helps well with cracks in the anus and almost never causes allergic reactions.
It is impossible not to say that most patients prefer to use Proctoglivenol ointment. They explain their choice by the fact that rectal suppositories end much faster, and the ointment can be used for a very long time. At the same time, it quickly and reliably removes all the unpleasant symptoms that accompany inflammation of hemorrhoids, and significantly speeds up the healing process.