Papaverine medication (injections) is an antispasmodic that has a hypotensive effect. The drug is able to inhibit PDE (phosphodiesterase), cause the accumulation of cAMP (cyclic adenosine monophosphate) lowering the level of Ca2 +.
The tool "Papaverine" (injection) relaxes and reduces the tone of smooth muscles of the internal organs (urogenital, digestive, respiratory systems) and blood vessels. Increased dosages can reduce the excitability of the heart muscle and slow down conduction (intracardiac). The drug "Papaverine" (injections) has a mild effect on the central nervous system. In large doses, it has a sedative effect.
The effectiveness of the drug is noted twenty to forty minutes after administration. The effect of the drug can last from four to six hours.
Papaverine (injections) is prescribed for spasm of smooth muscles of peripheral vessels (for endarteritis), organs in the abdominal cavity (renal colic, spastic colitis, pylorospasm, cholecystitis), heart (for angina pectoris in complex treatment), brain vessels (brain). The medication is indicated for premedication (preparation for surgery) as an auxiliary drug.
It is not prescribed for glaucoma, hypersensitivity, AV blockade, in old age, with severe renal failure, in childhood (up to six months).
With caution, the drug is used in people who have had a head injury, shock conditions, with adrenal insufficiency, prostate hyperplasia , hypothyroidism, supraventricular tachycardia.
The use of this medication can cause ventricular extrasystole, constipation, lowering blood pressure, allergic reactions, drowsiness, eosinophilia, increased liver transaminase activity.
In case of an overdose, diplopia, drowsiness, weakness, decreased pressure (arterial) are noted. Treatment is prescribed for symptomatic, supporting blood pressure.
Papaverine injections. Instructions for use.
Twenty-forty milligrams (1-2 ml of a two percent solution) per day are injected subcutaneously, intramuscularly, from two to four times. Intravenous injections are slow. Dosage is twenty milligrams.
The use of the drug "Papaverine" (injections) should be carried out only under the supervision of a doctor.
During therapy, it is necessary to exclude the intake of ethanol.
Clinically, the safety of the medication during lactation and pregnancy has not been established. Appointment in these conditions is not recommended.
When smoking, the vasodilating property of the drug decreases.
The drug "Papaverine" is able to reduce the hypotensive effect of methyldopa and the antiparkinsonian effectiveness of levodopa. There is an increase in the antispasmodic properties of the drug with simultaneous use with barbiturates. The antihypertensive effect of the drug may increase when used together with quinidine, reserpine, procainamide, tricyclic antidepressants.
The drug is also available in tablet form, in the form of suppositories. Candles have a local effect. Often they (suppositories) were used in gynecology to alleviate spastic conditions. Candles are considered a more powerful tool for relieving spasms of the pelvic organs.
The use of the drug in children should be monitored by a specialist.
Before the appointment, it is necessary to exclude the likelihood of contraindications.
Reception of the tablet form of the drug in children should be monitored by a specialist.
Papaverine is considered a fairly common drug for relieving cramping. As clinical practice shows, the medication is well tolerated by patients.