Along with antibiotic drugs, antifungal drugs also effectively help patients get rid of diseases that were caused by microorganisms sensitive to their active substance.
Currently, there are a huge number of such medicines. Their pharmacological characteristics often coincide. But most often, experts prescribe a drug such as Futsis to their patients. Instructions for use and features of this tool will be presented in the materials of this article.
Composition, shape and packaging
The drug "Futsis", the instructions for which are enclosed in a pack of cardboard, can be purchased in the form of tablets. Fluconazole acts as their active ingredient. Also, the composition of the medication includes auxiliary components.
The drug in question is available in doses of 50, 150, 100 and 200 mg. Tablets, in the amount of 4 pieces, are packed in a blister and a cardboard box, respectively.
In what other form can I buy Futsis? Instructions for use (tablets are not the only form of the mentioned funds) reports that this medication is also available in the form of a solution for infusion. The composition of the tablets includes fluconazole and such additional ingredients as microcrystalline cellulose, povidone K30, lactose, talc, magnesium stearate, croscarmellose sodium, sodium starch glycolate and others.
The solution for intravenous injections goes on sale in bottles of 100 ml.
As for the Futsis gel, it can be bought in tubes of 30 g.
Pharmacology of the drug
What features are inherent in the drug "Futsis"? Instructions for use states that each form of the said product has a pronounced antifungal effect.
Fluconazole is a synthetic derivative and belongs to the group of thiazole compounds. This substance helps to eliminate the enzymatic activity of specific components that are in fungal cells.
After using the drug, the biological synthesis of sterol compounds is disrupted, and the process of converting lanosterol to ergosterol is also inhibited. Such changes in the cell membranes contribute to the cessation of the growth of fungi.
Drug properties
What are the properties of the drug "Futsis"? Instructions for use (tablets have the same pharmacological characteristics as solution and gel) states that this drug is characterized by low toxicity. In this regard, it does not have a negative effect on the human body, as well as a significant effect on cytochromes and the amount of androgen hormones in blood plasma.
Pharmacokinetics of the drug
The instruction of "Futsis" states that after taking the tablets inside, they are pretty quickly and well absorbed from the digestive tract. According to experts, fluconazole has a high bioavailability. Eating does not have any effect on the absorption process of this product.
The maximum concentration of the active substance in blood plasma is observed approximately 60-90 minutes after administration.
The medication in question quite well penetrates the composition of biological fluids and tissues. Fluconazole also passes through the blood-brain barrier and is concentrated in the cerebrospinal fluid.
Withdrawal of the drug from the patient's body is carried out with urine. Its half-life is approximately 30 hours.
What kinetic parameters does Futsis solution have? The instruction says that the pharmacokinetics with intravenous administration of the drug is almost no different from oral administration.
As for the antifungal agent in the form of a gel, it has the same characteristics and activity. Especially effective gel manifests itself in dermatophytes and yeast.
During the external application of this agent, only a small amount of its active substance enters the bloodstream. In this regard, its systemic effect is completely excluded.
Also, experts found that the gel does not adversely affect the condition of the skin.
Indications for use
The instruction of Futsis reports that this drug is very often used in the treatment of infectious diseases of various localization, which were caused by microorganisms that are highly sensitive to fluconazole. As a rule, the medication in question is prescribed by gynecologists, dermatologists and mycologists.
So when should you use the drug "Futsis" (tablets)? The instruction reports that this form of medication is prescribed for:
- therapy of mycoses arising on the feet and in the inguinal region, onychomycosis, dermatomycosis and pityriasis versicolor;
- infections on the mucous membranes that were caused by fungi of the genus Candida;
- candida infections of different localization (for example, with candidaemia, disseminated candidiasis, candiduria and other forms of generalized candidiasis, which were caused by Candida fungus);
- bronchopulmonary non-invasive candidiasis infections;
- treatment of chronic and acute forms of vaginal candidiasis (recurrent);
- chronic candidiasis of the oral mucosa, which is associated with the wearing of removable dentures;
- treatment of histoplasmosis, sporotrichosis and other endemic mycoses.
For what other purpose can the Fucis oral drug (tablets) be prescribed? The instruction says that this medication is often used to prevent relapse in patients with:
- candida balanitis;
- vaginal chronic candidiasis;
- cryptococcal infections of different localization;
- fungal infections of different localization, if the patient suffers from immunodeficiency or receives cytostatic, as well as radiation therapy.
As for the solution for infusion, the instruction of "Futsis" indicates that this form of the drug is used in the treatment of:
- cryptococcal meningitis ;
- systemic fungal infections (candidaemia, candida infections of the eyes, candiduria, endocardium);
- cryptococcal infections of the skin and respiratory system.
A medication for external use can be prescribed for:
- dermatomycoses that cause yeast;
- dermatophytes (inguinal epidermophytosis, foot epidermophytosis , trichophytosis, multicolored lichen and candida infections).
Contraindications
And what is the treatment regimen with Fucis for children? The instruction says that this tool is not recommended for adults and children with increased individual sensitivity to the elements of the drug. Also, it is not used in the presence of allergies to azole compounds, similar in structure to fluconazole.
At what age do they acquire Futsis DT for children? The instruction informs that conventional tablets are extremely contraindicated for the treatment of babies up to 7 years old, and dispersed ones - up to 3 years.
Also, the medication in question is prohibited for use during pregnancy and breastfeeding. It is not used to treat people receiving the Cisapride and Terfenadine therapy, and those whose work is related to driving and potentially dangerous mechanisms.
The drug "Futsis DT": instructions for use
The medication in the form of tablets, as well as in the form of a solution and gel, should be used in different ways.
How should I take the drug "Futsis 50"? The instruction says that a medicine with an active substance content of 50-200 mg is used to treat not only adults, but also small patients from 3-7 years old.
Tablets are taken orally at any time of the day. The daily dosage of the drug is designed for one dose and is set only by the doctor (depending on the disease).
How to use dispersed tablets "Futsis" (50 mg)? The instruction says that before taking this drug, it should first be dissolved in ordinary water (about 5 ml).
For people suffering from genital candidiasis, the drug in tablets is prescribed once in an amount of 150 mg. For the prevention of relapse of chronic vaginal candidiasis (thrush), the medication is used in the same dose, but only once a month.
As a rule, the dosage of the drug in question does not depend on its method of use, and also does not change when switching from parenteral administration to oral administration.
The method of applying the infusion solution
The instruction of "Futsis" reports that the preparation for intravenous administration contains 200 mg of fluconazole, as well as 100 ml of a solution of sodium chloride (isotonic).
Before the introduction of the medication, the patient should limit the intake of water and sodium. It is also necessary to take into account the content of chlorine and sodium ions in the solution.
Despite the absence of pronounced drug incompatibility, the drug in question should not be mixed with other drugs for infusion.
Gel application
Gel "Futsis", like tablets, must be used once a day. The external agent is gently rubbed into the affected skin areas, as well as the areas around them.
Specialists report that to achieve a therapeutic effect, the patient requires only a small amount of gel. It is thoroughly rubbed over the entire surface of the fungus-affected area in order to prevent the development of maceration.
Now you know how to use Fucis Gel, Solution and Tablets (150 mg). The instruction says that the dosage, as well as the duration of use of each of the presented forms should be determined only by the attending physician.
Side effects
What side effects can the use of the Fucis 150 infusion solution, gel and tablets cause? The instruction says that against the background of using these funds, the patient may develop the following undesirable reactions:
- severe headaches, tremors, dizziness, and cramps;
- arrhythmia and tachycardia;
- nausea, abdominal pain, vomiting, indigestion, diarrhea, and others;
- allergic reactions to the skin in the form of alopecia, toxic epidermal necrosis, itching, skin rash, urticaria, swelling, Stevens-Johnson syndrome.
Also, the use of this medication can affect the performance of laboratory tests (neutropenia, leukopenia, agranulocytosis, hypokalemia, thrombocytopenia, the level of triglycerides and cholesterol in the blood).
The listed side effects require the immediate cessation of taking Futsis.
Overdose cases
In case of an overdose of Fucis solution or tablets, the patient may develop negative symptoms such as dizziness, headache, and hallucinations. In addition, paranoid human behavior cannot be ruled out.
In case of an overdose, the stomach is washed and symptomatic therapy is carried out.
Compatibility with other drugs
The simultaneous use of Fucis solution and tablets with anticoagulants significantly enhances their effect. In this regard, constant monitoring of prothrombin time parameters is required .
The drug in question can increase the plasma concentrations of Benzodiazepine, Midazolam, Cyclosporin, Phenytoin and Rifabutin in the blood. When combining flucanosole with any of the listed funds, dose adjustment of the drug and the supervision of an experienced specialist are required. If you neglect this advice, then such combinations can enhance side effects, cause the development of psychomotor reactions and so on.
With regular use of hydrochlorothiazide with Futsis, a significant increase in the concentration of fluconazole in the blood can be expected. However, this does not require dosage adjustment.
Taking the medication mentioned does not reduce the effects of oral combined contraceptives.
In the course of Fucis therapy for patients with diabetes, the likely development of hypoglycemia should be considered.
The concomitant use of this drug with "Rifampicin" requires an increase in the dose of fluconazole.
The combination of Futsis and Tacrolimus very often causes a mutual enhancement of their nephrotoxicity.
Cost and analogues of an antifungal agent
After prescribing the Fucis antifungal drug, many patients ask how much it costs. It should be noted that the price of this medicine in different pharmacy chains may vary slightly. Its average cost is about 300-400 rubles (regardless of the form of issue).
Drugs with similar pharmacological characteristics include drugs such as Fluconazole, Fucortsin, Clotrimazole, and Livarol. However, when taking them, it must be borne in mind that they can have completely different contraindications and side effects. Therefore, to replace "Futsis" with these funds, you should definitely contact a doctor. By the way, it is the latter who will be able to choose the right and most effective treatment regimen for you.
Antifungal Patient Reviews
Most often, the drug in question leaves positive reviews. According to the latter, it is quite actively used in gynecological practice in the treatment of thrush. However, many people claim that the antifungal agent “Futsis” helps get rid of this unpleasant disease for a rather long period of time. However, experts say that we should not forget about additional medications that help restore normal flora in the vagina.
Speaking about the effectiveness of the drug "Futsis", one can not help but mention the negative responses. Some patients who used this medication note that they had side effects while taking the tablets or using the solution. As a rule, they are manifested by swelling, itching of the mucous membranes of the nose and eyes, fever and severe headache.
As for the gel "Futsis", then reviews about it are much less common. In those that are, it is said about the high effectiveness of this tool, especially in the treatment of dermatomycosis.