Problems in the cardiovascular system can hardly be considered a rarity. Today, many people suffer from high blood pressure, which can be a symptom of various diseases. Fortunately, it can be eliminated with the help of medicines.
“Azomex” (tablets) is considered to be a rather good drug for high blood pressure. Instructions for use, indications for use, side effects, prices and expert opinion are the main issues that interest each patient. So what is the cure?
Azomex tablets: description of the drug
Many people are diagnosed with arterial hypertension. And in such cases, doctors recommend the drug "Azomex". The composition and form of release, as well as the properties of the drug, are what patients are primarily interested in.
The drug is released in the form of small tablets of white, sometimes yellowish color, placed in blisters of 10 pieces. The main active substance here is S - amplodipine in the form of a besilate - in one tablet contains 2.5 or 5 mg of this component.
As for the combination of excipients, the preparation also contains magnesium stearate, lactose, colloidal silicon dioxide, microcrystalline cellulose, croscarmellose sodium and yellow iron oxide.
What properties does the medicine have?
I recommend taking the Azomex drug for many people. What does he help from? How does it affect the body?
The main active component of the drug is the levorotatory isomer of amplodipine with pronounced pharmacological activity. This substance blocks slow calcium channels, as a result of which the penetration of calcium ions into the cells of the myocardium and vascular smooth muscle becomes impossible. A similar effect reduces the tone of the vascular wall, which, accordingly, leads to a decrease in blood pressure.
In addition, the drug has antianginal properties. Under its influence, the expansion of peripheral vessels occurs. Since the drug does not affect the heart rate, after a decrease in peripheral vascular resistance, the load on the myocardium, as well as the muscle's need for oxygen, becomes less. The drug also relieves spasm of smooth muscles from the coronary vessels, normalizing the flow of blood, and, accordingly, the nutrition of the heart muscle.
It is worth noting that Azomex does not have a pronounced effect on the metabolism of carbohydrates and fats, so it can be used to treat patients with gout, diabetes mellitus and bronchial asthma.
After administration, the tablet dissolves rather quickly and is absorbed in the digestive tract. By the way, meals do not affect the absorption of the drug. The maximum concentration of the active substance in the blood is observed after about 6 to 12 hours. The drug acts relatively slowly, and therefore does not cause a sharp drop in blood pressure, which can also be considered an advantage, especially when it comes to long-term therapy.
The bioavailability of the active substance is approximately 70 - 80%. The drug metabolism occurs in the liver - here it breaks down to inactive metabolites, which are then excreted from the body by the kidneys with urine. The half-life is quite long - 35 - 50 hours. In older people and patients with congestive heart failure, the drug is excreted longer.
The main indications for use
In what cases is it advisable to take the drug "Azomex"? Indications for use - this is arterial hypertension, which occurs against the background of certain diseases of the cardiovascular system. In particular, the medicine is often prescribed to people with coronary artery disease. Tablets help with vasospastic angina pectoris, stable angina pectoris and Prinzmetal angina.
The drug "Azomex": instructions for use
Tablets can be taken only as prescribed by the doctor, following all his recommendations, since otherwise the manifestation of side effects is possible. The specialist will also select the most suitable schedule and dosage.
The tablets should be swallowed whole, without chewing and drinking plenty of fluids. The effectiveness of the drug does not depend on food intake.
In what quantities should I take the Azomex 2.5 hypertension medication? The instruction indicates that the initial dose is 1 - 2 tablets (not more than 5 mg of the active drug). If the effect of taking is absent, the dose of the drug can be increased. The maximum daily amount of active substance is 10 mg.
Are there any contraindications?
For many readers, the interesting question is whether all patients can take the drug "Azomex" (tablets). The instruction provides information that the drug still has some contraindications.
To begin with, it must be said that it is not prescribed to people who have an increased sensitivity to any of the constituent components. In addition, tablets should not be taken with a decrease in pressure (if the indications of systolic blood pressure do not exceed 90 mm Hg). Tablets have age restrictions - they are not used to treat children and adolescents under 18 years of age. Also, the drug should not be taken by pregnant women and nursing mothers.
There are some other contraindications. In particular, the drug is not prescribed for patients with severe renal or hepatic insufficiency. The drug is not used for anuria, shock, acute myocardial infarction, cardiogenic shock. Contraindications also include severe aortic stenosis and unstable angina.
What side effects are possible?
Can there be any complications in patients who have been prescribed the drug "Azomex" (tablets)? The instruction confirms that the likelihood of side effects exists, although, according to reviews, such cases are rarely recorded.
So what reactions can therapy bring?
- Against the background of taking the medicine, some disturbances in the digestive system may occur, in particular, pain in the stomach, nausea, dyspepsia, flatulence, stool disorders, dry mouth. Gingival hyperplasia and anorexia are extremely rare. It is also possible to increase the activity of liver enzymes, impaired liver function, difficulty in the outflow of bile.
- Sometimes there are disorders of the cardiovascular system, including arrhythmias, hypotension, shortness of breath, facial flushing, swelling of the extremities.
- Side effects from the nervous system include dizziness, headaches, increased drowsiness, sleep disturbances, depression, tremors, parasthesia.
- Some patients complain of pain and muscle weakness, cramps.
- Allergic reactions are possible, including erythema, allergic dermatitis, hair loss.
- Other side effects include an increase in daily urine and increased urination, gynecomastia, increased sweating, and sexual dysfunctions.
All of the above violations are reversible and disappear after withdrawal or reduction of the dose of the drug.
Overdose: signs and methods of treatment
Against the background of taking too large doses of this drug, excessive relaxation of the vascular walls of the peripheral vessels is possible, which leads to hypotension. Sometimes there is also a violation of the heart rhythm.
After taking too much of the drug, gastric lavage and enterosorbents are recommended. In the presence of serious disorders, a solution of dopamine and calcium gluconate is administered intravenously to patients. Symptomatic therapy aimed at maintaining body functions is also prescribed.
How much are the pills?
Immediately it is worth saying that the price of these tablets varies over a very wide range. It all depends on the city and pharmacy in which you make the purchase, as well as on the manufacturer. A package of 30 pieces with a dose of 2.5 mg costs about 200 rubles. The same number of tablets, but with a dosage of 5 mg, costs about 370 rubles. In addition, there are cheaper pharmaceutical products made in India. A pack of the same number of tablets from an Indian manufacturing company costs 120 (2.5 mg) or 180 (5 mg) rubles.
Effective drug analogues
For one reason or another, far from every person suffering from high blood pressure, the Azomex drug is suitable. What to do in such cases?
In the modern pharmaceutical market there are a lot of high-quality analogues that provide the same effect. For example, patients are often offered Almodak, Amlodipine, and Norvadin as a substitute. For arterial hypertension, drugs such as Semlopin, Tenox, and Vasodipine are effective.
In any case, it is worthwhile to understand that only the attending physician who is familiar with the history of your disease can choose the right remedy. Self-medication in such cases can be dangerous.
Reviews of specialists and patients
Today, many patients, doctors prescribe the drug "Azomex" (tablets). Instructions for use here are quite simple, the number of contraindications is minimal, and side effects are rare, despite their impressive list. The medicine really helps to normalize blood pressure, and acts quickly enough. The undoubted advantage is that the drug is perfect for long-term treatment.
Patient reviews are also positive. During therapy, blood pressure returns to normal, unpleasant symptoms of hypertension disappear. The medicine is convenient to use, and it doesn’t cost that much - the price of some analogues is much higher.
The drug "Azomex" is available on prescription and it is not always easy to find in a pharmacy - this is perhaps the only negative. Naturally, there are people whom the tablets do not help or even cause side effects. But the same can be said about almost any drug, since it is impossible to accurately predict its effect on the human body. And, of course, do not forget that these pills are only part of complex therapy for diseases of the cardiovascular system.