According to the instructions for use, "Neobutin" is a drug that regulates the motility of the gastrointestinal system. It performs the function of stimulating the smooth muscles of the intestine, providing an antispasmodic effect. Consider in more detail its instructions for use, learn about what analogues exist, and also get acquainted with the opinions of patients who already have experience of treatment with this pharmaceutical agent.
Description of the drug
Trimebutin, the active ingredient of this drug, has an effect on the intestinal enkephalinergic system and serves as a regulator of its peristalsis. Influencing peripheral receptors, including those located directly in the smooth muscles of the entire gastrointestinal tract, it regulates the process of motility without directly affecting the functioning of the central nervous system. So, the substance trimebutin completely restores the necessary physiological activity of the intestinal muscles against the background of various diseases of the digestive organs, which are associated with impaired motility.
Normalizing sensitivity to visceral function, according to the instructions for use, "Neobutin" provides an analgesic effect against the background of abdominal pain. The composition of this medical product, in addition to trimebutine maleate, also includes other excipients.
Pharmacokinetics of the drug
After using the drug inside, “Neobutin” is able to be absorbed quite quickly from the gastrointestinal tract. The bioavailability of the drug is from four to six percent. Moreover, the rate of binding to plasma proteins is low and reaches about five percent. Trimebutin to a small extent is able to penetrate the placental barrier. This element undergoes the process of digestion in the liver, and is excreted due to the kidneys, which occurs mainly in the form of metabolites in the amount of seventy percent during the first twenty-four hours.
Indications for use of "Neobutin"
Doctors prescribe this drug for violations of the motility of the gastrointestinal tract against the background of the following functional diseases and conditions:
- The presence of gastroesophageal reflux disease.
- The existence of dyspeptic disorders against gastroduodenal diseases, such as abdominal pain, digestive disorders, nausea and vomiting.
- Bowel irritation syndrome, which is manifested by pain and colic in the abdominal cavity, and is also accompanied by intestinal cramps, diarrhea, flatulence and constipation.
- In the postoperative period with paralytic intestinal obstruction.
- In the case of preparation for x-ray or endoscopic examination of the digestive organs.
- Against the background of dyspeptic disorders associated with impaired motility of the gastrointestinal tract in children.
This is confirmed by the instructions for use of "Neobutin".
Forms of release of "Neobutin"
The drug is released in the form of tablets of 100 milligrams, which have a prolonged effect. The tablets are coated.
Instructions for use of the drug "Neobutin" and methods for dosing it
The pharmaceutical agent "Neobutin" is used orally before meals. Adults, as well as children over twelve years of age, should consume 100-200 milligrams three times a day. In order to prevent the occurrence of a relapse of the irritable bowel after the necessary course of treatment during remission, doctors recommend continuing to take this drug in the amount of 300 milligrams per day for twelve weeks. Children under the age of twelve need to use 50 milligrams three times a day. Very young people under the age of five can take 25 milligrams three times a day.
This is indicated by instructions for the use of "Neobutin."
Side effect
Against the background of taking the described drug, the following side effects are likely to occur:
- Dry mouth, accompanied by unpleasant taste sensations.
- The occurrence of diarrhea, constipation, dyspepsia and nausea.
- A feeling of drowsiness, fatigue, severe dizziness, and in addition, a feeling of anxiety and anxiety.
- Short-term fainting.
- Feeling of heat and cold.
- The appearance of skin rashes.
- Violation of the menstrual cycle in women, and in addition, soreness and enlargement of the mammary glands.
- Urinary retention.
This is confirmed by the instructions for use and reviews of "Neobutin".
Contraindications to the use of the drug "Neobutin"
It is forbidden to use this tool in the presence of the following factors:
- Patients intolerant to lactose.
- The presence of glucose-galactose malabsorption.
- Period of pregnancy.
- Children under three years of age when it comes to tablets.
- Hypersensitivity to trimebutin.
The use of "Neobutin" during pregnancy and breastfeeding
In the process of experimental studies, no data were revealed on embryotoxicity and teratogenicity of trimebutin. But nevertheless, in view of the actual lack of necessary clinical information, the use of Neobutin tablets (instructions for use confirm this) during pregnancy is completely contraindicated.
Experts do not recommend using the drug during breastfeeding due to the lack of reliable clinical information that would confirm the safety of using the product at this time.
The use of the drug for children
According to the instructions for use, "Neobutin" (a photo of the drug is in the article) in the form of tablets is strictly contraindicated in children under the age of three years. For those older, the dose is determined according to age.
Special instructions for use of the product
With a course of therapy for irritable bowel syndrome during the period of its acute manifestation, it is possible to take the drug in the amount of 600 milligrams per day for four weeks. You can also continue treatment after the stage, reducing the dose by half. As part of the continuation, the drug is taken for twelve weeks, which significantly reduces the risk of a relapse of the disease.
The influence of "Neobutin" on the ability to drive vehicles and other mechanisms
Taking into account possible side effects, such as dizziness and other factors, you should refrain from driving, as well as engaging in other potentially dangerous activities.
This describes the instructions for use for Neobutin. The price and reviews of doctors will be presented below.
Analogs
Structural analogues of Neobutin in terms of the active substance include Retard and Trimedat.
Bactistatin, Guttalax, Dietetel, Irmalaks, Lactofiltrum, Mukofalk, Spazmonet, Fitomucil and other drugs are analogues in the therapeutic effect that help in the treatment of irritable bowel syndrome.
We reviewed the "Neobutin" instructions for use and analogues.
Reviews
With regard to reviews of Neobutin, it can be said that people mostly report fairly good tolerability of the product. This medication is able to quickly relieve pain, stabilizing the intestines.
Patients in their comments share that shortly after taking "Neobutin" they felt noticeable relief, which came a few days later. Such patients, as a rule, are constantly tormented by flatulence. People are afraid to eat food, because no matter what they eat, their stomach starts twisting and in addition to this, something constantly rumbles in it. As patients admit, while taking the medication, all of these unpleasant symptoms quickly disappear.
Parents satisfied with this drug report in their reviews that the drug quickly leads to normalization of the stool in the child, helping to overcome dyspepsia. This confirms the "Neobutin" instructions for use. Analogs should be selected by a doctor.
People, among other things, like that this drug is quite affordable, since its price ranges from only 150 to 200 rubles per pack. True, there are some complaints that it is not always possible to buy it in a pharmacy, since it can often be absent.
Among the negative reviews, it is reported that sometimes the drug does not help. Experts comment on this situation by the fact that in relation to some serious diseases, such as, for example, an ulcer, it really can not always help, since the treatment of such ailments should be approached differently. In general, doctors speak of him as an effective and safe tool.
The article deals with "Neobutin" instructions for use, reviews and analogues.