Zinaprim is a popular antibacterial drug used in veterinary practice to treat a wide range of infectious diseases of domestic and farm animals. Available in the form of a solution for injection or fine powder for dilution with water and oral administration.
The composition of the drug "Zinaprim"
The instruction for use speaks of the content of two main active components, such as:
- sulfamethazine;
- trimethoprim.
Both substances are synthetic. Their combination in the desired concentration enhances each other's action (synergism) and gives a powerful bactericidal effect. The mechanism of action is aimed at blocking all important physicochemical processes taking place in the cell. Due to this, the activity spectrum of the drug covers a large number of pathogenic bacteria causative agents of dangerous diseases:
- Escherichia coli;
- Clostridium spp .;
- Salmonella spp .;
- Proteus mirabilis;
- Haemophilus influenza and gallinarum;
- Streptococcus pneumoniae, pyogenes, faecalis, etc .;
- Staphylococcus aureus;
- Brucella spp.
Excipients can be citric acid, metabisulfite or sodium hydroxide, hydrochloric acid, deionized water.
As analogues can be called "Sulfatrim", "Sulfprim 48", "Trimethosul", "Ditrim". Which drug to choose in a particular case, the doctor must decide.
Indications for use
The drug is effective against a wide range of bacterial infections of domestic and farm animals. Among them:
- pulmonary infections, bacterial blood infection (septicemia), enteritis in cats and dogs;
- pneumonia, gastroenteritis, mastitis, vibriosis, brucellosis, salmonellosis, genitourinary infections, purulent inflammation, skin diseases in cattle and small cattle ;
- diarrhea, parotid inflammation (mumps), and pneumonia in horses;
- suppuration, malignant edema, dysentery, pneumonia of pigs;
- pasteurellosis, pneumonia, rhinitis, colibacillosis, enteritis in rabbits;
- infectious complications of viral diseases, pasteurellosis, salmonellosis, colibacillosis, streptococcal infections of poultry.
Judging by the reviews, this is a very effective drug. Rabbit breeders say that this tool helps with such an ailment as coccidiosis. However, before starting treatment, you must always consult a veterinarian.
"Zinaprim": instructions for use in veterinary medicine
Method of application vary for individual groups of animals. If necessary, consult a veterinarian beforehand. The daily dose of the drug for cattle, goats, sheep and pigs is 1 g of powder or 1 ml of solution per 10 kg of body weight. The same ratios apply to pets. At first, the interval between doses should be at least 12 hours. The duration of such treatment is from 3 to 5 days. If necessary, increase the dose of Zinaprim.
Instructions for use for rabbits involves the use of 1 g of the product per 1 liter of drinking water on the first day of treatment. In the next 2 or 3 days, the dose is reduced by half and limited to only a liter of water per day, with the Zinaprim drug dissolved in it.
Instructions for use for birds are similar. However, it is forbidden to use it for the treatment of laying hens, since the product penetrates the eggs, which makes this food unsafe. For the treatment of gastrointestinal tract disorders in chickens, both powder and Zinaprim solution can be used. Instructions for use for chickens are similar to those for adult birds.
Solutions are prepared daily in an amount that satisfies the natural needs of the animal. For the treatment period, the diluted drug should be the only source of drinking water. Those who complied with all of the above requirements, in reviews, most often characterize the drug as effective and efficient.
Being in the body
The drug is rapidly absorbed through the gastrointestinal tract or injection site and is distributed throughout the body as soon as possible, penetrates all tissues and organs. Most sulfamethazine and trimethoprim are administered in the urine in the form of compounds after some time, the smaller - with bile.
The components of the drug can settle in the tissues for a long time. For this reason, meat and milk of animals that have been treated with Zinaprim should not be eaten. Instructions for use warns that the slaughter of animals for meat should be done only after 5 days from the date of use of the product. Do not use eggs of birds that have undergone treatment. "Zinaprim" is a veterinary drug and was classified as a hazard class 3 in terms of its effect on the human body.
Side effects and contraindications
Exact and conscientious adherence to all recommended doses is not a negative result. However, prolonged use can lead to diarrhea, vomiting, nausea, impaired renal function, and digestive upset caused by Zinaprim.
Instructions for use warns of the danger of intoxication in case of an overdose. In this case, pathological damage to the tissues of the kidneys and a violation of their work occurs. If this happens, the medication should be urgently stopped and the appropriate antidotes administered to the affected animal. In the event of unpleasant symptoms with full compliance with all established doses, individual intolerance of any components is possible.
Animals suffering from renal and hepatic insufficiency should be given the drug with great care, as this can cause serious malfunctions in the operation of these systems. During pregnancy and lactation of the young with milk, Zinaprim should not be used.
Precautions for working with the drug
Instructions for use indicate the need to observe basic hygiene measures. Before and after using Zinaprim, you need to thoroughly wash your hands and exposed parts of the body to prevent the product from penetrating the human body or entering the mucous membranes of the eyes and nose. You should also make sure that this product is stored at home while observing the temperature regime and out of the reach of children.
When using the powder, it is necessary to prevent its contact with the skin using protective gloves. It is advisable not to smoke, drink or eat during the procedure. It is highly recommended not to work with this tool for pregnant and lactating women. And also use the drug near food, tableware, household appliances. Ingestion of Zinaprim can cause severe poisoning. If this still happened, you should consult a doctor.