High blood pressure is becoming an increasingly common problem in people of any age, gender and status. Moreover, such a condition can occur as an independent ailment or become a consequence of a disease. In healthy people, the pressure is usually close to 120/80. If the values deviate from the norm, doctors can prescribe the drug "Tenzotran", instructions for which will be discussed in our article. We will also talk about analogues of this medication.
Structure
According to the instructions for use, Tenzotran has a hypotensive effect. The drug is produced in the form of tablets, which are coated with a film coating.
They have a light pink, pink or dark pink hue, rounded in shape. The composition of the medication includes the following substances:
- Moxonidine.
- Lactose Monohydrate.
- Povidone.
- Crospovidone.
- Magnesium stearate.
Healing properties
According to the instructions for Tenzotran, the active substances of the drug selectively excite brain receptors, resulting in a decrease in OPSS, strength and heart rate. The drug very effectively lowers blood pressure, lowers the level of norepinephrine, aldosterone, renin and angiotensin-II. Able to exert a hypoglycemic effect, prevent myocardial hypertrophy. Also, the drug has a cardioprotective and lipid-lowering effect, activates the production of growth hormone in the body.
Indications and contraindications
According to the instructions and reviews, Tenzotran is recommended for use in the presence of arterial hypertension (a condition that is determined by a steady increase in systolic pressure to an indicator of 140 mm Hg or more).
Limitations:
- Syndrome weakness syndrome (a group of rhythm and cardiac conduction disorders, which are characterized by a decrease in the frequency of electrical signals from the sinus node).
- Atrioventricular block of the second and third degree (violation of the electrical impulses from the atria to the ventricles, due to which the slowdown of the heartbeat is carried out).
- Chronic kidney disease.
- Angioneurotic edema (acute disease, which is characterized by the rapid appearance of local edema of the mucous cavity, as well as subcutaneous tissue and the epidermis itself).
- Galactosemia (a hereditary disease provoked by a metabolic disorder in which an abnormal process of galactose metabolism occurs).
- Glucose-galactose malabsorption syndrome or lactase deficiency (a genetic disease in which cells that line the intestines are not able to absorb galactose, as well as glucose).
- Unstable angina (represents a period of coronary heart disease, which threatens the appearance of myocardial infarction).
- Liver disease.
What other limitations does the medicine have?
According to the instructions, Tenzotran is not prescribed in the following cases:
- Age to eighteen.
- Breast-feeding.
- Severe Parkinson's disease (a chronic progressive brain lesion in which changes in the structures of the substantia nigra are observed).
- Hemodialysis (a method of hardware purification of blood in acute and chronic kidney diseases).
- Glaucoma (a large group of diseases of the organs of vision, which is characterized by a regular or periodic increase in intraocular pressure above normal).
- Chronic heart disease.
- Epilepsy (a chronic disease that manifests itself in a predisposition of the body to a sharp appearance of seizures).
- Intermittent claudication (a symptomatic complex, which is characterized by a violation of the microcirculation of blood vessels located in the legs with manifestations of pain of a transient nature, as well as occurring during walking).
- Depression (a mental illness characterized by a persistent deterioration in mood, as well as motor inhibition).
- Cerebrovascular disorders (diseases of the brain that are caused by pathological changes in cerebral vessels with impaired microcirculation of the brain).
- Raynaud's disease (paroxysmal pathological process in small capillaries, which is characterized by vasospasm and impaired blood supply to the limbs).
- Myocardial infarction (one of the clinical forms of coronary heart disease, which occurs with the onset of ischemic necrosis of a portion of the heart muscles, due to the absolute or relative insufficiency of its microcirculation).
- Pregnancy.
How to use
According to the instructions for use with Tensotran, the drug is taken orally, washed down with water, regardless of the meal. The initial concentration of the drug, as a rule, is 0.2 milligrams per day at a time, preferably in the morning. If necessary, after three weeks of using the medication, daily dosage can be increased to 0.4 mg in one or two doses.
The maximum daily dosage used in one application is 0.4 milligrams, in two doses - 0.6 mg. In people with creatinine clearance of 30-60 milliliters per minute, and those on hemodialysis, a single concentration should not exceed 0.2 milligrams, daily - 0.4 mg.
"Tenzotran": analogues and substitutes
Substitutes are:
- Physiotens.
- Moxarel.
- Cint.
- "Moxonidine".
- "Moxonitex".
- "Moxogamma".
Before replacing "Tensotran" with an analog, it is necessary to consult a doctor in order to avoid negative consequences.
Physiotens
The main active component of the drug selectively exerts an inhibitory effect on imidazoline L1 receptors, due to which brain activity decreases, as well as capillaries expand and the level of total blood pressure decreases.
According to the instructions for use, the analogue of Tenzotran has a small effect on alpha2-adrenergic receptors, as a result of which it can provoke the appearance of dryness in the oral cavity and a calming effect. Tablets do not have any effect on the frequency and strength of heart contractions.
After oral administration of Physiotens, the active component is absorbed quite quickly into the general bloodstream. The active substance is evenly distributed throughout the tissues.
The drug in the liver is involved in metabolic reactions, resulting in the formation of inactive decay products, which are excreted mainly with urine. The half-life is about five hours. Physiotens - is an effective analogue of Tenzotran.
The drug has certain features, which include:
- During treatment, constant monitoring of the level of blood pressure, as well as the rhythm of heart contractions, is necessarily carried out.
- Before using Physiotensa, as well as sometimes during therapy, it is necessary to perform an electrocardiogram of the heart.
- Cancellation of treatment should be carried out gradually, since a sharp cessation of taking the drug can lead to an increase in blood pressure.
- With extreme caution, the medication is prescribed to patients with a concomitant violation of the absorption of carbohydrates in the structures of the digestive system, since it contains lactose.
"Moxonidine"
In people who suffer from moderate arterial hypertension, as well as insulin resistance and obesity, the active component of this drug increases the insulin sensitivity index by twenty percent.
According to the instructions, the analogue of "Tenzotran" "Moxonidine" has a negative effect on the ability to drive a car or carry out work that requires increased attention and speed of psychomotor reactions. Therefore, during its use, it is necessary to refrain from such actions.
For patients under the age of eighteen, this medicine is prescribed extremely rarely if safer substitutes are not available.
Moxonitex
This is an antihypertensive drug. It belongs to the selective agonists of imidazoline nerve endings. The medication provides reflex control of the autonomic nervous system.
To a small extent, it binds to central adrenoreceptors, and also leads to a decrease in systolic and diastolic blood pressure both with a single and with prolonged use. The duration is more than twelve hours.
According to the instructions for use with the drug, during prolonged therapy, there is a decrease in hypertrophy of the muscles of the heart of the left ventricle, as well as a decrease in the severity of signs of myocardial fibrosis, stabilization of myocardial microcirculation.
During therapy, it is required to monitor heart rate, blood pressure and an electrocardiogram.
Moxarel
Antihypertensive medication, the main active ingredient of which is moxonidine. It is an antihypertensive substance, characterized by a central mechanism of action that selectively activates imidazoline-sensitive receptors in the brain stem structures.
The result of stimulating imidazoline nerve endings is considered to be a decrease in blood pressure. Unlike other sympatholytic antihypertensive drugs, the likelihood of dryness of the oral mucosa and a calming effect when using the drug is very low. Moksarel is the Russian analogue of Tenzotran; it is produced by Vertex CJSC.
The effect of "Moxarel" provokes a decrease in total vascular resistance and blood pressure. The drug helps improve insulin sensitivity in patients with insulin resistance, as well as obesity.
Cint
The acting component of the drug is moxonidine, which selectively acts on the imidazoline nerve endings, which leads to a decrease in sympathetic activity.
According to the instructions for use, the drug reduces the resistance of tissues to insulin. A decrease in systolic and diastolic blood pressure with prolonged use of the drug is associated with a decrease in the pressor action of the sympathetic nervous system on the peripheral capillaries, but the cardiac output and heart rate do not change significantly.
According to reviews of the analogue of "Tensotran," the maximum hypotensive effect can be achieved seven hours after oral administration of the drug. During therapy, constant monitoring of blood pressure, heart rate is needed.
There is no information about the negative impact of the active substance on the ability to drive a car and complex mechanisms. There is evidence of drowsiness and dizziness during Cynto therapy.
Moxogamma
It is an antihypertensive drug that is an imidazoline nerve ending agonist. The drug "Moxogamma" is responsible for toning the capillaries, expands their patency, lowers resistance, improves blood flow to the heart muscles. The pressure decreases gradually, its jumps after stopping the medication is not observed.
Patients who took Moxogamma should monitor their heart rate and blood pressure every day. In addition, it is necessary to perform an electrocardiogram twice a month. It is impossible to abruptly cancel the drug, because an increase in blood pressure, as well as the appearance of withdrawal syndrome, is possible.
If you need to drive a car, you need to take the drug in twelve hours. "Moxogamma" has a negative effect on concentration, and also has a calming effect. Taking alcohol at the same time with the medication is contraindicated.
Opinions
As a rule, patients leave positive reviews about drugs that reduce blood pressure. Some people with minor hypertension have used these drugs as a single drug. They were prescribed to many patients simultaneously with beta-blockers and diuretics.
Patients note that some drugs lower blood pressure more and more quickly, for example, Physiotens, Cint. People who took these medicines rarely had negative effects in the form of nausea, weakness, dizziness.