Analogue of "Diflucan" - means "Fluconazole"

The Diflucan analogue, Fluconazole, is an antifungal drug with a highly specific effect. The medication is able to block the activity of a number of enzymes, prevent the conversion of lanosterol to ergosterol. In addition, the drug increases the permeability of cell membranes, prevents the replication and growth of pathogens. The drug is effective in opportunistic mycoses provoked by Candida genus fungi, including generalized types of candidiasis due to immunosuppression. When taken orally, the drug is characterized by good absorption. The absorption rate does not affect the rate of absorption.

Diflucan cost
The bioavailability of the drug is about 90%. The drug reaches its maximum blood content after 30-90 minutes. The drug is well distributed in tissues and fluids, penetrates into milk. It should be said that the price of Fluconazole medication is an order of magnitude lower than the cost of Diflucan (for the latter, you will have to pay between four hundred and eight hundred rubles).

Indications

The medicine "Fluconazole" (an analogue of Diflucan) is prescribed for cryptococcal meningitis, cryptococcosis and other localizations of cryptococcal infection in patients with a normal immune response and with a different type of immunosuppression. Indications include candidiasis of a generalized type, disseminated candidiasis, candidaemia, other types of invasive infections, the causative agent of which is a fungus of the genus Candida.

tablet analogs
The medicine is recommended for the prevention of fungal infections in patients with malignant tumors. An agent is prescribed for mycosis of the feet, groin, trunk.

Dosage regimen

The analogue of Diflucan, Fluconazole, is prescribed to patients from the age of fifteen with a mass of more than 50 kg. With cryptococcal infections of various localization in the first day at a dose of 400 mg. Subsequently, the amount of medication is reduced to 200 mg per day. The duration of therapy for these pathologies depends on the effectiveness of the treatment, which is confirmed by the results of mycological studies. The use of cryptococcal meningitis should last at least six to eight weeks. With disseminated candidiasis, candidaemia, and other invasive candidiasis infections, the amount of the drug on the first day is 400 mg, then the dose is reduced to 200 mg. In case of insufficient treatment effectiveness, the dosage is increased back to 400 mg. The duration of treatment depends on the effectiveness of the drug.

Diflucan analog

Side effect

The analogue of Diflucan, the drug Fluconazole, can provoke dizziness, pain in the head, abdomen, abdominal pain, loss of appetite, and nausea. Based on the treatment, thrombocytopenia, an allergic reaction in the form of facial edema, epidermal toxic necrolysis, and itching of the skin can develop. Analogues of tablets can cause a violation of the liver, kidneys, hypokalemia, hypertriglyceridemia.

Contraindications

Do not prescribe a drug under the age of 4 years, with intolerance to its components. Combined use with the medication "Terfenadine", "Astemizole" and others that contribute to the lengthening of the QT interval is contraindicated. Caution during therapy is shown with a predisposition to various pathologies (to electrolyte imbalance, organic heart diseases, etc.).


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