In the article, we consider the analogues of “Periciazine”.
This tool is an antipsychotic. The drug can produce an antipsychotic, sedative, pronounced antiemetic effect. It is endowed with a medication of pronounced anticholinergic and adrenergic blocking activity, usually causing a hypotensive effect. Compared with Chlorpromazine, it has a more pronounced antiserotonin activity and may have a stronger central sedative effect.
Trade Name and Composition
The presented tool has in its composition the component of the same name. Excipients in this case are calcium phosphate dihydrate, croscarmellose sodium and magnesium steart. There are two trade names for periciazine: directly “Periciazine”, as well as “Neuleptil”.
Pharmacological effect of “Periciazine”
So, "Periciazine" is an antipsychotic drug (antipsychotic). This medication is able to have antipsychotic, pronounced antiemetic and sedative effects. With a pronounced anticholinergic and adrenergic blocking activity, the drug causes a hypotensive effect.
The initial daily dose of this remedy, as a rule, is 5 or 10 milligrams. And for patients with hypersensitivity to phenothiazine, doctors usually prescribe 2 or 3 milligrams. Average daily dosages are, according to the instructions, from 30 to 40 milligrams, the frequency of administration is three to four doses per day. It is preferable to carry out treatment in the evening. The maximum daily allowance for adults is usually 60 milligrams.
"Periciazine" for children
For children, as well as for elderly people, the initial dosage is 5 milligrams. Further, the amount of the drug gradually increases to 10 or 30 mg.
Indications
As indicated by the instructions for use, "Periciazine" is used for treatment in the following cases:
- Against the background of the development of psychopathy, which is distinguished by an excitable and hysterical character, as well as with psychopathic conditions in the presence of schizophrenia in a person.
- In case of paranoid forms of mental disorders.
- In the presence of organic, vascular presenile and senile disease.
- As an aid in psychotic disorder to overcome the residual phenomenon with a predominance of impulsiveness, hostility or aggressiveness.
Contraindications
This drug is not used in a number of situations:
- Against the background of severe heart and vascular diseases.
- With severe inhibition of the nervous system.
- In case of toxic agranulocytosis in the anamnesis.
- In the presence of angle-closure glaucoma and porphyria.
- Against the background of prostate diseases.
- During pregnancy and lactation.
This must be considered before the appointment.
Drug interaction
In accordance with the instructions for use with "Periciazine", while using with drugs that have a depressing effect on the nervous system or with ethanol, breathing problems may occur. When combined with drugs that cause extrapyramidal reactions, it is likely to increase the severity and frequency of extrapyramidal disorders.
In the case of simultaneous use, a significant increase in the anticholinergic effect of other drugs is possible, while the antipsychotic activity of the antipsychotic may decrease. When used concurrently with anticonvulsants, a decrease in the seizure threshold is expected. In combination with medications for the treatment of hyperthyroidism, the risk of developing agranulocytosis increases.
Analogues of this drug
The analogues of this tool include:
- The drug "Thioridazine."
- Means "Pipothiazine".
- A medication called "Neuleptil."
Next, we consider the synonyms of “Periciazine” in more detail.
Thioridazine
The pharmacological substitutes for this drug include “Sonapax” along with “Melleril”. These drugs can have a mild antipsychotic effect, combined with mild stimulatory, timoleptic and antidepressant effects.
The analogue of “Peritsiazin” “Thioridazine” is used for schizophrenia (in the case of acute and subacute form), against the background of psychomotor agitation, neurosis and other diseases. This medication is contraindicated in the presence of an allergic reaction, a change in the blood picture, coma. With prolonged use of the drug, toxic retinopathy may develop.
The release format for this analogue is dragee. As part of the treatment, unless otherwise prescribed by the doctor, one tablet is used three times a day.
What other analogues of Peritsiazin can be found on sale?
The drug "Pipothiazine"
Pharmacological substitutes for this drug include Piportil. It is prescribed to patients for the treatment of various forms of schizophrenia, to combat psychosis with hallucinations, as well as in the treatment of mental pathologies and abnormalities in children. Pipothiazine is used only in a hospital setting.
A two percent oil solution may have a prolonged effect. The average dose of Pipothiazine for adult patients in the amount of 100 milligrams (4 milliliters of solution) is administered intramuscularly once every four weeks. In the treatment of chronic psychosis, this remedy can be prescribed to a patient orally in a dosage of 20 or 30 milligrams once a day. After achieving a stable therapeutic effect, the amount of medication can be reduced to 10 milligrams per day.
Contraindications to the use of this analogue are impaired renal function along with the angle-closure form of glaucoma. The format of the release of Pipothiazine is tablets along with drops, solution and ampoules. Next, consider an analogue called "Neuleptil."
Neuleptil: solution and drops
This drug is produced in a solution for oral use (drops) and in capsules. The main active ingredient of the drug is a substance called periciazine. "Neuleptil" eliminates the aggressiveness that occurs in patients with mental disorders.
The drug can have an antipsychotic effect by inhibiting the reticular formations and lowering their effect on the cerebral cortex. The drug produces a depressing effect on the mediator functions of dopamine. The sedative effect of the drug is caused, as a rule, by the blocking of central adrenoreceptors located in the area of the reticular formations and a decrease in the activity of histamine receptors.
According to the instructions for use, Neuleptil drops are not prescribed for patients if they suffer from angle-closure glaucoma, Parkinson’s pathology, and receive treatment with dopaminergic antagonists. This analogue, among other things, is not prescribed when the patient has hypersensitivity to the main component of periciazine along with heart failure and Goldflam disease. It is best to abandon the use of the medication in question if the patient has a urinary retention, which is caused by pathologies of the prostate gland, porphyria, agranulocytosis, pheochromocytoma, and so on.
With great care, "Neuleptil" is prescribed to patients when they have heart disease in combination with vascular pathologies, kidney diseases, pregnancy and liver problems.
The use of "Neuleptil"
In the event that there are no other purposes, the patient should take this analogue in a dosage of 30 to 100 milligrams. The maximum daily dose of the drug is 0.2 grams. Children take the described medicine in an amount of from 0.1 to 0.5 milligrams per kilogram of body weight. The medication is taken two to three times a day.
We examined the analogues of Peritsiazin and instructions for it.