Currently, there are many different remedies for hypertension and angina attacks. One of them is also such as "Pharmadipine" (drops) medicine. What this drug is from, we will consider further in more detail.
Structure
The active substance in this case is nifedipine (nifedipine). In 1 ml of this solution, it is in a certain amount. Namely, when recalculated to 100%, the dry type substance is 20 mg. It turns thirty drops.
"Pharmadipine" (drops), the instructions for use of which will be discussed below, in its composition has the presence of such auxiliary substances as polyethylene glycol 400 and ethanol 96%.
Pharmacological properties
This drug has a kind of pharmacodynamics. As mentioned above, "Pharmadipine" (drops) contains the substance nifedipine, which has a hypotensive and antianginal effect. It helps block the entry of calcium ions into cardiomyocytes and into certain smooth muscle cells of peripheral and coronary arteries through voltage-dependent slow corresponding channels of cell membranes. This is an important property. Nifedipine also relaxes the smooth muscles of blood vessels, dilates peripheral and coronary arteries, and eliminates spasms. This reduces blood pressure, OPSS, afterload on the heart and oxygen demand of the myocardium. Also, while taking this drug, certain manifestations are still observed. Namely, there is a slight decrease in myocardial contractility and heart function, and platelet aggregation is also slightly reduced .
Pharmacokinetics
In this regard, Pharmadipine (drops), the instructions for use of which are discussed in this review, has its own characteristic features. When taken internally, it is well absorbed in the digestive tract. Its bioavailability is about 40-60 percent. A particularly rapid development of the effect (after 5–10 minutes) is observed with sublingual administration. It is important to know. Usually, the greatest effect appears after 30-40 minutes. Eating does not particularly affect the rate of absorption of this drug. The manifestation of the hemodynamic effect will remain for 4-6 hours. At the same time, up to 90 percent of nifedipine binds to blood plasma proteins. A drug such as Pharmadipine (drops) is metabolized in the liver. The presence of a total clearance of nifedipine is from 0.4 to 0.6 l / kg / h. It is excreted from the body mainly in the form of inactive metabolites. The half-life can range from 2 to 4 hours. In the elderly and patients with cirrhosis, the metabolism of nifedipine is significantly slowed down. As a result of this, their half-life indicator of this drug may increase by about 2 times. In this case, it is required to reduce the dose and increase the intervals between doses of the specified drug. Nifedipin is not cumulated in the body. Also, it can penetrate in small quantities through the placental and blood-brain barrier. At the same time, it is excreted in breast milk.
Indications for use
Pharmadipine (drops) is prescribed in the following cases:
- With the occurrence of essential and symptomatic arterial hypertension.
- For the treatment and prevention of angina pectoris.
- With cardiomyopathy hypertrophic.
- With Raynaud’s disease.
Application
Take "Pharmadipine" (drops) sublingually. With a sharp increase in blood pressure (for example, 180 / 100–190 / 110 mm Hg), a single initial dose of this drug for adults as a whole is about 3-5 drops (2–3.35 mg). Elderly patients are also prescribed a certain dosage. Namely - no more than 3 drops (about 2 mg). Also, the indicated amount can be dripped on a small piece of cracker or sugar. His patient should hold as long as possible in his mouth. With insufficient results, the dosage of this drug is gradually increased to clinical effectiveness. In this case, it all depends on the individual approach. With subsequent manifestations of increasing blood pressure should focus on the established dose. There is also one more specific criterion. It lies in the fact that if blood pressure increased to 190 / 100–220 / 110 mm Hg. Art., then taking drops of this drug can be gradually increased to 10-15 (6.7-10 mg). In this case, pressure changes in a particular patient should be taken into account. This is important to know.
You also need to consider the presence of increased sensitivity of some patients to a drug such as Pharmadipine (drops), which are positive reviews. In such cases, the dosage is selected individually. Start with 3 drops, and then gradually increase by 2–3 (1.34–2 mg) until the desired clinical effect is achieved.
It should be remembered that when the initial dose of this medicine is exceeded, a sharp decrease in blood pressure can occur!
Side effect
When using a drug such as Pharmadipine (drops from pressure), manifestations of nausea, tachycardia, arterial hypotension, and “flushing” of face blood may occur. In some cases, allergic reactions in the form of leg edema, skin rash may occur. Symptoms of weakness, dizziness, and headache may also occur.
Contraindications
It is forbidden to take a drug like Pharmadipine (drops) if you are hypersensitive to its components, cardiogenic shock, severe aortic and mitral stenosis, hypotension, tachycardia, as well as during lactation and pregnancy.
Overdose
In this case, some negative symptoms may appear. Namely, an overdose of a drug such as Pharmadipine (drops) may be accompanied by the occurrence of heart failure, shock, metabolic acidosis and seizures, and a sharp drop in blood pressure. When these symptoms occur, it is necessary to resort to certain emergency measures. They consist in washing the stomach, taking activated charcoal, administering calcium chloride and sympathomimetics, and symptomatic therapy.
Features of use
"Pharmadipine" (drops from pressure) or its substitute should be used exclusively with careful clinical monitoring of elderly patients and patients who have:
- Unstable angina pectoris.
- Severe heart failure.
- Hypertrophic cardiomyopathy.
- Acute aortic stenosis.
- Severe pulmonary hypertension.
- Acute cerebrovascular accident.
- Diabetes.
- Violations of the functionality of the kidneys and liver.
The dosage of other drugs that are used with nifedipine should be established individually. Cardiac glycosides can also be used while taking a medication such as Pharmadipine (drops), the analogues of which are indicated below in this text.
When taking nifedipine with simultaneous intravenous administration of magnesium sulfate, pregnant women need careful monitoring of blood pressure. This should be done because there is the possibility of lowering blood pressure, which can harm both the mother and the fetus.
Patients with impaired liver function should also be monitored closely. In severe cases, the dose should be reduced.
Nifedipine is metabolized via the cytochrome P450 3A4 system. As a result of this, drugs that inhibit or induce the indicated region of enzymes can alter the effect of the “initial passage” or the clearance of this substance. With the concomitant use of nifedipine with drugs of this type, blood pressure should be monitored. If necessary, you should resort to a reduction in the dosage of such a drug as Pharmadipine (drops).
Conducting separate in vitro experiments revealed a relationship between the use of calcium antagonists, in this case nifedipine, and biochemical reverse changes in sperm, which affect the deterioration of the ability of the fertilization.
Taking "Pharmadipine" (drops), you should refrain from the activity of a potentially dangerous type that requires increased attention. Namely, it is not worth driving vehicles, working with other mechanisms, and so on.
Interactions
"Pharmadipine" (drops) has a hypotensive effect. This property contributes to the strengthening of drugs from the category of blockers. That is, "Pharmadipine" (drops) increases the effect of β-adrenergic receptors, diuretics, nitrates, other antihypertensive agents, drugs and drinks containing alcohol, tricyclic antidepressants. In some cases, nifedipine helps to reduce the concentration of quinidine in the blood plasma. But the cancellation of it significantly increases it. Thus, using combination therapy, it is recommended to monitor the level of quinidine concentration in the blood plasma.
Diltiazem reduces the clearance of a drug such as Pharmadipine (drops). "Fentanyl" significantly enhances the manifestations of the hypotensive effect. As a result, before administering this medication (for less than 36 hours), you should stop taking Pharmadipine. The combined use of β-blockers with nifedipine can lead to the development of hypotension. "Farmadipin" (drops) helps increase the concentration of theophylline, carbamazepine and digoxin in the blood. "Rifampicin" leads to a weakening of the therapeutic effect of nifedipine, while accelerating its metabolism. "Cimetidine" helps to increase the concentration of "Pharmadipine" in the blood plasma.
Terms and conditions of storage
In this case, there are certain criteria. Store Pharmadipine (drops) at room temperature in a dry place. The medicine should be protected from light and out of the reach of children. Storage of this drug is designed for up to 1 year and 6 months. After the bottle is opened - 28 days.
Vacation
"Pharmadipine" (drops) is sold exclusively by prescription.
Packaging
In bottles of 25 ml or 5 ml. They are enclosed in a pack.
Pharmadipine (drops): analogues in Russia
There are many substitutes for this drug. The main ones are:
- Cordipin.
- "Nifedipine."
- "Adalat."
- Cordaflex.
- Corinfar Uno.
- "Cordaflex RD".
- "Phenigidin."
- "Osmo Adalat."
- "Cordipine Retard."
- "cordipin xl."
Conclusion
Now you know what a drug like “Pharmadipine” (drops) is, what it helps and what properties it has. In any case, before taking this drug, you should seek the advice of a qualified doctor.