Antibiotic compatibility table: features of use, contraindications

In the article, we consider the antibiotic compatibility table.

Modern treatment is very difficult to imagine without the use of antibiotics. The names of drugs that belong to this group of funds are present in many recipes that fit into domestic aesculapius. True, in recent years there have been more and more statements that the use of antibiotics is not a panacea at all, and very often can cause extremely negative reactions, which are difficult to cope with.

Everyone should familiarize themselves with the antibiotic compatibility table.

Antibiotics: benefit or harm?

Antibiotics are classified as chemicals whose action is aimed at blocking the further development of certain microscopic organisms, as well as at their direct destruction. However, the toxic potential of this category of drugs is so great that it can cause great harm to the entire human body.

In some cases, the effect of antibiotics is so serious that patients are forced to choose between the possible occurrence of complications of an infectious pathology and the risk that occurs during the use of drugs of this pharmacological group. Especially detrimental effect occurs when antibiotics with alcohol simultaneously enter the body.

Antibiotic Compatibility Chart

Such drugs are important to be able to combine correctly. Consider the antibiotic compatibility chart below for treatment.

Not everyone will understand all of these designations. Decipher the compatibility table of antibiotics of different groups as follows:

• The designation "++" indicates the total effect of the drug.
• "+" Reports that sometimes an increase in action may be noted.
• “-” indicates an increase in total toxicity.

Features of the use of antibiotics in medicine

With the antibiotic compatibility table, everything is clear enough.

The choice of the optimal dosage, method of administration and duration of treatment is based on the severity and localization of inflammatory processes. The more difficult the disease is, the larger the dose of the drug should be. In the treatment of a severe form of the inflammatory process, it is preferable to carry out parenteral administration of the drug, and in case of sepsis, the intravenous use of the drug is mandatory (as the condition improves, you can switch to intramuscular treatment and taking the medication inside). The duration of treatment of septic processes should be at least six weeks.

Antibacterial drugs are canceled without first reducing the dosage so as not to add to them. After a long course of such therapy for the restoration of normal microflora, patients are recommended “Kolibacterin” along with “Bifidumbacterin” and “Acidophilin”. In all cases of staph infections, antibiotic therapy is combined with immunotherapy. Purulent complication is eliminated through adequate surgical intervention.

Antibacterial therapy is carried out only with an infectious disease caused by microbial flora. The antibiotic should be used in full therapeutic doses, for a sufficiently long time, given the possible sensitivity of pathogens to it. At the same time, they carry out the whole range of therapeutic measures that are aimed at eliminating the local manifestations of the inflammatory process, and, in addition, at strengthening the patient's natural defenses and normalizing homeostasis.

Why consider antibiotic compatibility?

Contraindications

Today, there are several categories of patients who are affected by the effect of antibiotics especially intensively:

• Pregnancy is a strict contraindication in most cases. The woman’s body at this time is sensitive to various chemical compounds. The greatest danger of the use of an antibiotic for the fetus is in the initial trimester. The use of such drugs is allowed only against the background of the development of such a serious pathology as pneumonia, which threatens the life of the mother and child.
• The feeding period is also considered a contraindication, but not absolute, since antibiotics are often prescribed in connection with the occurrence of postpartum complications. In this case, a temporary refusal of feeding, which can be resumed several days after completion of treatment, will be the best solution.
• Patients who suffer from liver and kidney failure. In the presence of such diseases, the effect of antibiotics can adversely affect the condition, since it is these organs that are responsible for processing the drug and removing it from the body.
• The next specific contraindication for the use of antibiotics is alcohol consumption. Today, it has been precisely established that such medicines and alcohol are incompatible, because alcohol affects the metabolism and activity of medications. In addition, their parallel consumption can cause serious side effects in the form of nausea, vomiting, shortness of breath and seizures. There is evidence that antibiotics and alcohol, which were consumed simultaneously, sometimes led to death.

In those cases when a person nevertheless allows a parallel consumption of alcohol and drugs, the Polysorb tool will help reduce the risks of complications, which relieves the body of intoxication and contributes to a more intense withdrawal of ethanol.

Below we consider the compatibility of alcohol and antibiotics. There is no such data in the table.

Why are alcohol and antibiotics incompatible?

Three types of incompatibilities between antibacterial drugs and alcohol are known:

• Disulfiram-like reactions. Some antibiotics can inhibit the decomposition of ethyl alcohol, against which a product related to incomplete metabolism, that is, acetic aldehyde, can accumulate in the body. This is what provokes intoxication, manifested by vomiting, and shortness of breath. A similar effect has a drug that is widely used to treat alcoholism - “Disulfiram”, from which the name of this type of interaction came from. Metronidazole, along with Ornidazole, Tinidazole and the cephalosporin antibiotic Cefotetan, does not allow alcohol to decompose normally. In the event that a person takes any of these drugs, then alcohol is completely contraindicated. Specialists are advised to refrain from ethanol for at least 24 hours after completion of treatment with Metronidazole. It also takes three days after treatment with Tinidazole.
• Metabolic dysfunction. Ethyl alcohol, getting into the liver, usually decomposes under the influence of the enzyme cytochrome. This element is involved in the metabolism of certain drugs, for example, such as Erythromycin, Cimetidine, antifungal drugs (Voriconazole, Itraconazole, Ketoconazole). In the framework of the simultaneous intake of alcohol and drugs in the liver, which claim their share of cytochrome, a conflict inevitably arises. Often, the cure is the cure. An accumulation of the drug occurs in the body, which can lead to intoxication.
• Toxic effects on the nervous system. Sometimes antibiotics have specific side effects, manifested by drowsiness, sedation, dizziness. Everyone knows about the calming effect of alcohol. But the simultaneous combination of two sedatives in the form of an antibiotic and alcohol can inhibit the nervous system, which is especially dangerous for the elderly, drivers and so on. The drugs that inhibit the central nervous system when used together with alcohol include Cycloserine along with Ethionamide, Thalidomide and some others. So everything is serious, you need to add alcohol to the antibiotic compatibility table. The consequences of their use can be the saddest.

Compatibility of fluoroquinolones with other antibiotics

Also, the compatibility of fluoroquinolones with other antibiotics is not indicated in the table. Let's talk about it.

Norfloxacin, which refers to fluoroquinolones, cannot be combined with antacids at the same time (in this case, the interval between doses should be more than two hours). The combination with nitrofurans can lead to a decrease in antibacterial activity. “Pefloxacin” should never be diluted with sodium solution. In this situation, the effect of indirect anticoagulants may increase along with the concentration of theophylline in the blood plasma.

The compatibility of antibiotics with each other should be taken into account without fail.

“Ciprofloxacin” increases the concentration of “Theophylline” in the blood plasma. From a pharmaceutical point of view, this medicine is incompatible with solutions that have an acidity of more than seven. Do not combine this antibiotic with physically unstable solutions. In combination with Warfarin, the concentration of the latter in the blood increases

Compatibility of sulfonamides with antibiotics

In the table described by us on the compatibility of antibiotics and sulfonamides there is also no information.

With the simultaneous use of Cyclosporin with sulfonamides, it is possible to increase the metabolism of this drug, which will be accompanied by a decrease in serum concentration and effectiveness. At the same time, the risk of nephrotoxicity is increased. “Phenylbutazone” along with salicylates and “Indomethacin” can displace drugs belonging to the group of sulfonamides from communication with plasma proteins, increasing their concentration.

Milk and antibiotics

Is milk and antibiotic compatible ? It is difficult to say with certainty that milk is compatible with such medicines. Of course, the fermented milk product is rightfully considered useful, in this regard, many believe that washing down with them the drugs, most likely, the effect of the treatment will intensify. But antibiotics can hardly be attributed to such drugs. They are very moody, and, getting into the stomach, react to food or drink instantly. Doctors recommend taking the antibiotic with clean water. And what will be the consequences if you drink them with milk? Can I use this product at all while taking an antibacterial drug?

In the event that a person takes antibiotics at the same time as food, then milk can be drunk, this will not lead to negative consequences. The body will absorb the substance, and the useful components of the product will only strengthen it. But, when this drug is not related to the penicillin and tetracycline groups, it is better to refuse to use it with food, especially with milk.

Such drugs relieve inflammation, but because of them, microflora is greatly destroyed. To restore it, you need to consume dairy products, but not in combination with a medicine. Milk should not be used with antibacterial drugs belonging to the category of tetracyclines, penicillins, compounds such as azithromycin and so on. If a person takes such medications, you need to choose the right products, otherwise the digestive system will suffer.

Experts say that some products already contain antibiotics. When they are consumed, sensitivity to the drug decreases, immunity becomes weak and allergies can occur. In order to check at home whether an antibiotic is present in milk, special knowledge is not needed. To do this, leave the glass with the product on the table overnight at room temperature. In the event that in the morning it does not turn sour, it means that a large amount of antibacterial substance is present in it.

Are there any reviews on the compatibility of antibiotics and alcohol? We will understand further.

Reviews of doctors and patients

In the reviews, doctors write that such a group of medications such as antibiotics should be prescribed strictly by a specialist who is treating a particular patient. Given the peculiarities of compatibility of such drugs with each other, and with other drugs in the treatment of pathologies, it is extremely important to be able to understand the issues of combination treatment, otherwise the consequences can be very serious.

Everyone knows that antibiotics cannot be combined with alcohol. But not all patients are in a hurry to abide by this rule. Those who violated medical recommendations report a significant deterioration in well-being due to the incompatibility of ethanol with this group of drugs. People also write that during the treatment period they prefer to refrain from drinking such medicines with milk.

Conclusion

Thus, antibiotics have become an integral part of the treatment of many diseases. Over the long years of their existence, the great effectiveness of such drugs has been proven. Fatal diseases can be cured for a long time without complications and negative effects on the body. But in order for the effect of antibiotics to be effective, they should be taken correctly.

We reviewed the antibiotic compatibility chart.