What is a drug like Dexilant? Instructions, analogues and main characteristics of this medication will be discussed later. You will also learn about what diseases this drug is prescribed and what patients say about it.
Basic disease information
What diseases does Dexilant cure? According to the instructions, the drug in question exhibits high therapeutic efficacy in GERD, that is, gastroesophageal reflux disease. It is the most common chronic disease of the digestive system and occurs due to reflux, that is, the constantly repeated casting of the contents of the duodenum or stomach into the esophagus. As a result of such a pathological process, damage to the mucous membrane of the esophagus, and sometimes upstream organs, including the pharynx, larynx, bronchi and trachea, occurs.
The main signs of the disease
How does GERD manifest itself? Symptoms (only an experienced gastroenterologist should prescribe the treatment for this disease) of such a pathology are always the same. Most often, the patient complains of heartburn, belching with gas or acid, acute sore throat, pressure in the stomach that occurs after eating, and discomfort in the spoon, worse after eating.
How else can GERD with esophagitis be detected? Treatment of this ailment usually begins after an eructation of bile with semi-digested food masses. It should also be noted that sometimes in patients with the mentioned diagnosis there are signs such as vomiting and urging for it, a feeling of pressure behind the sternum, profuse salivary discharge and dysphagia. In addition, people with esophagitis may complain of chest pains that extend to the shoulder, arm, neck and back.
In the event that you have at least one of the symptoms presented, you must immediately contact the clinic for a full medical examination.
The composition of the drug, its detailed description and form
What drug is most effective for GERD (symptoms, treatment of this disease are discussed in this article)? Most often, for the treatment of such a disease, as well as the complete elimination of its clinical signs, experts recommend taking the Dexilant medication. It is available in the form of modified-release capsules, as well as an opaque gray body and a blue cap that carries the TAP logo.
The contents of the capsules are granules of white or almost white color. Their active component is dexlansoprazole. Also, the composition of the medicine includes such auxiliary components as hyprolose, sugar grits, macrogol 8000, magnesium carbonate, polysorbate 80, sucrose, silicon colloidal dioxide, low substituted hyprolose, triethyl citrate, hypromellose, a copolymer of methyl methacrylate and methacrylic acid, talc, a dispersion of methacrylic acid dioxide.
Dexilant capsules can be purchased in plastic bottles, which are placed in packs of cardboard.
Therapeutic features of the drug (capsules)
What are medicinal capsules like Dexilant? Reviews report that the drug is a proton pump inhibitor (PPI). It is able to suppress the secretion of juice of the main digestive organ by inhibiting the K + / H + -ATPase located in the parietal cells of the stomach. Also, after taking this medication, the final stage of hydrochloric acid secretion is blocked.
How does Dexilant Medication work? The instruction says that after taking the capsule inside, it breaks down in the stomach and releases two different types of granules, which are coated with an enteric coating. Thus, the main substance of this agent begins its active action, depending on the pH level in various parts of the small intestine.
Due to the presence of a capsule shell and granular content, the Dexilant preparation, the instruction of which is presented below, has a prolonged action and also contributes to a significant decrease in the secretion of gastric juice over a long time.
Indications for taking capsules
In what cases is a patient prescribed a drug such as Dexilant (the price of capsules is quite high)? According to the instructions, this tool is indicated for reception:
- with erosive esophagitis of any severity (for treatment);
- erosive esophagitis and relief of manifestations of heartburn (as maintenance therapy after treatment);
- gastroesophageal reflux disease, including non-erosive reflux disease (as a symptomatic treatment).
Prohibitions for the administration of oral capsules
Under what conditions can Dexilant be used? The instruction informs about the following contraindications for taking this remedy:
- minor age;
- high sensitivity to any of the components of the drug;
- concurrent use with HIV protease inhibitors;
- the period of gestation;
- breastfeeding time.
We can not say that the drug in question contains sucrose. In this regard, its use is not recommended for people with malabsorption of glucose-galactose intolerance to (hereditary) fructose, as well as with sucrose-isomaltase deficiency.
Cautious prescription of the drug
With caution, the drug "Dexilant" (analogues of the drug are listed at the end of the article) is prescribed with concurrent administration:
- "Tacrolimus."
- CYP2C19 isoenzyme inhibitors.
- Warfarina.
- "Methotrexate".
Medication "Dexilant": instructions for use
It is advisable to take the drug in question only after consultation with an experienced gastroenterologist. Capsules are prescribed inside as a whole, regardless of the time of the meal.
If necessary, the capsule shell can be opened. At the same time, its contents should be poured into a tablespoon, mixed with non-acidic applesauce, and then swallow immediately, without chewing.
How to treat erosive esophagitis of any severity? With this disease, the drug "Dexilant" (60 mg) is prescribed once a day. The course of therapy with this remedy is eight weeks.
Supportive treatment after treatment of erosive esophagitis, as well as to relieve symptoms of heartburn, requires taking 30 mg of the drug once a day. In this case, the treatment course should be about six months.
In the presence of severe and moderate erosive esophagitis, the recommended dosage of the drug is 60 mg per day. The therapeutic course of treatment for such a disease should last up to six months.
How is symptomatic treatment of GERD or NERD carried out? The drug "Dexilant" (30 mg) for this disease is prescribed one capsule once a day. The course of treatment of such a pathology should last at least four weeks.
In people with impaired liver function of moderate severity, the daily dosage of the drug in question should not exceed 30 mg. To date, there are no clinical data on the administration of this medication by people with severe disorders.
Dosage adjustment in elderly patients, as well as people with impaired renal and hepatic function of mild severity, is not required.
Negative manifestations after taking the medicine (capsules)
What side effects can Dexilant capsules cause? Reviews say that after taking the medication in question, patients develop many negative reactions. Among them, the following can be especially distinguished:
- diarrhea, drug-induced hepatitis, flatulence, anaphylactic shock, abdominal pain, constipation, nausea;
- epidermal necrolysis, vomiting, toxic exfoliative dermatitis, respiratory tract infections (upper), hypersensitivity;
- hyponatremia, anaphylactic reactions, pruritus, exudative malignant erythema (Stevens-Johnson syndrome), hypomagnesemia, oral candidiasis;
- acute renal failure, pain and discomfort in the abdomen, urticaria, dry mouth, rash, swelling of the oral mucosa, leukocytoclastic vasculitis, pancreatitis;
- change in liver function indicators, generalized rash, autoimmune hemolytic anemia, fractures, cough;
- heat attack, laryngeal edema, increased blood pressure, a feeling of tightness in the throat, headache, idiopathic thrombocytopenic purpura;
- dizziness, blurred vision, dysgeusia, paresthesia, hearing loss, cramps;
- stroke, vertigo, transient ischemic attack, visual impairment, auditory hallucinations, swelling of the face, insomnia, changes in appetite, depression, weakness, and so on.
Overdose Signs
What negative effects occur when exceeding the recommended doses of the drug "Dexilant"? To date, there have been no reports of significant cases of overdose resulting from the use of this drug. At the same time, experts argue that with a single use of this medication in a dosage of 120 or 300 mg, no serious side effects occur. As for taking this medicine at 60 mg twice a day, this method causes an increase in blood pressure to 140/90 mm RT. Art.
How to eliminate signs of overdose? In the presence of clinical manifestations, symptomatic therapy is performed. It should also be noted that dexlansoprazole is not excreted by hemodialysis.
Drug Interactions
How does dexlansoprazole interact with other drugs ? According to the instructions, this ingredient can be prescribed to patients who take clopidogrel, without any risk of interaction. In the case of parallel reception of the specified funds correction of the dosage regimen is not required.
The complete absence of a clinically significant interaction of the drug in question with Diazepam, Theophylline and Phenytoin was also noted.
Concurrent use of dexlansoprazole can affect the absorption of drugs whose bioavailability depends on the pH level in the stomach (for example, iron salts, ampicillin esters, Digoxin, Ketoconazole and Erlotinib).
The simultaneous administration of Dexilant with Tacrolimus contributes to an increase in the concentration of the latter in the blood, especially in people after transplantation.
With the parallel use of the medication in question with Fluvoxamine, there is a high probability of an increase in the systemic effect of the former.
The simultaneous use of methotrexate and dexlansoprazole can lead to an increase, as well as maintaining a high concentration of the first or its metabolite in blood serum. If you want to take a high dose of methotrexate, it is recommended that you temporarily stop taking dexlansoprazole.
The lactation period and the period of gestation
Is it possible to take the drug “Dexilant” during gestation? According to experts, during pregnancy this medicine is contraindicated.
If the mentioned remedy must be prescribed to a nursing mother, then she should stop breastfeeding.
Special information
What information should be provided to the patient before prescribing Dexilant?
Before starting dexlansoprazole therapy, it is necessary to exclude the presence of a malignant neoplasm in the patient, since taking the medication in question can mask the symptoms, as well as delay the correct diagnosis.
If all the symptoms of an existing disease persist despite adequate treatment, then an additional examination is necessary.
In the process of using proton pump inhibitors, which, in fact, includes dexlansoprazole, there is an increased risk of gastrointestinal infections accompanied by diarrhea caused by various bacteria, including the genus Clostridium difficile. Such infections are especially common in hospitalized patients. This fact must be taken into account if, during the treatment of diarrhea, a person's condition does not improve. In this case, patients are advised to use the minimum effective dosage of dexlansoprazole with short-term treatment.
In people who receive high doses of the drug in question, or with prolonged treatment with proton pump inhibitors for twelve months or more, the risk of osteoporotic fractures of the hands, bones of the hips and spinal column increases significantly. Therefore, patients at risk of developing osteoporotic fractures must always adhere to the dosages recommended by the doctor.
Sometimes, while taking the medication in question, patients showed asymptomatic and symptomatic hypomagnesemia. As a rule, such conditions occurred if the Dexilant treatment process lasted at least three months. It should be recalled that the symptoms of hypomagnesemia are arrhythmia, tetany, and seizures. Therapy of this condition requires replenishment of magnesium and discontinuation of proton pump inhibitors.
In people who need long-term treatment or who are simultaneously taking PPIs with digoxin or other drugs that can cause hypomagnesemia (including diuretics), the concentration of magnesium in the blood should be constantly monitored (both before and during therapy).
Due to the high likelihood of developing dizziness, as well as visual impairment, people during the Dexilant treatment period need to refrain from driving vehicles and other mechanisms that require special attention from a person.
The drug "Dexilant": analogues, cost, reviews
What can replace the drug in question? Experts say that the main analogues of this drug are the following:
- "Velos" is an effective tool designed to combat acidity. Its active ingredient very quickly inhibits the production of excess acid, facilitating and eliminating pain.
- “Barol” - in its characteristics is very similar to “Dexilant”.
- "Gerdin" - quickly restores acidity, prevents the destruction of the intestinal walls, and also relieves heartburn.
Also, the Omez drug is referred to the analogues of the mentioned medicine. Which is better - Omez or Dexilant? It is impossible to compare these funds, since they contain completely different substances, although they are both designed to lower the increased acidity of the gastric juice.
Sometimes, for the treatment of gastroesophageal reflux disease, experts recommend the use of the Nexium medication. At the same time, patients are interested in what to choose - “Nexium” or “Dexilant”? Doctors say that both of the mentioned tools do a good job. However, when choosing a particular drug, it must be borne in mind that the first medication causes much less side effects.
How much do Dexilant capsules cost? The price of this medicine depends on the margin of the pharmacy network. The average cost of this tool is approximately 900 rubles.
What do patients say about this medication? Many people taking this remedy claim it is overpriced. However, experts report that this drug is very effective. It has a prolonged effect and quickly normalizes the acidity of the juice of the stomach. At the same time, doctors stipulate that Dexilant may cause some side effects, but, as a rule, they disappear when adjusting its daily dose.
It should also be said that the independent use of this medication is prohibited. This fact is due to the fact that when prescribing it, it is necessary to take into account the presence of pathologies of the patient in the kidneys and liver, as well as the age of the patient.