Our body is a complex system that can defend itself very well against external influences. But in the world there are many pathogenic microorganisms and fungi that are looking for an opportunity to break the body's protective barriers and use it for their own needs. Symptoms of infection with these simple organisms are mycoses. The disease is not too dangerous, but it greatly reduces the quality of life, as it causes severe discomfort and many cosmetic problems.
What are mycoses? These are diseases of the skin and nails, hair and internal organs of a person, the causative agent of which are fungi related to opportunistic microflora. On guard of health is such a drug as Irunin. Analogs, cost and range of actions we will consider today.
What is the drug "Irunin"
This is primarily a broad-spectrum antifungal agent. The main active substance - itraconazole - violates the integrity of pathogenic fungi and prevents their reproduction. At the same time, there are microorganisms that are more or less sensitive to this substance. It is most effective against dermatomycetes, molds, yeasts such as Candida. However, the market has not only Irunin. Analogs provide a wide selection and the ability to regulate treatment costs. Below we will take a closer look at the price range of these medicines.
Pharmacological properties
Let's look at the mechanism of action of the drug "Irunin". Instructions for use (the price of this drug does not mean poor quality at all) presents it to us as an antimycotic drug with a wide spectrum of action. Active active substance disrupts the life cycle of fungi, inhibiting the production of ergosterol by the membrane of their cells. The drug effectively destroys dozens of different varieties of fungi. The maximum concentration in the blood is reached after about 4 hours. Decay products are completely excreted approximately 7 days after the cessation of treatment. In this case, the therapeutic concentration in the epidermis remains for about a month. In keratin nails, the drug will retain its healing power for approximately 200 days after the end of the 90-day course of treatment.
Indications
Where is “Irunin” (analogues) used primarily? This is dermatology (it is prescribed most often with ringworm and multi-colored lichen), as well as gynecology. The very first problem that women go to the consultation is candidiasis (or thrush). The drug is especially effective for candidiasis with damage to the mucous membranes and skin, onychomycosis, vulvovaginal thrush. At the same time, it is Irunin most often appointed. Analogs are not inferior to it in efficiency, but they are less replicated means.
Contraindications
However, not in all cases the drug “Irunin” may be prescribed. Its use in childhood is strictly prohibited, it is also prohibited in the first trimester of pregnancy. Starting from the 4th month of pregnancy, this drug can only be prescribed if the expected benefit to the mother is higher than the possible risk to the fetus. The doctor should be very careful when prescribing the drug to people suffering from heart failure, chronic diseases of the lungs and respiratory system, serious liver damage.
Side effects
They are quite serious, so you should carefully study their list before making a decision on taking the drug. Due to the wide spectrum of action, antifungal pills can not only provoke various side effects, but also affect almost all vital systems. In addition, each of them can react with various manifestations. So, the digestive system often responds to the effects of the drug with various disorders and, very rarely, intoxication and liver damage. The central nervous system often responds with migraine attacks, drowsiness, and dizziness. In women, a menstrual cycle may fail. There are allergic reactions in the form of skin rashes, pulmonary edema is possible.
It should be noted that most often antifungal tablets are well tolerated, but any of the side effects may occur with varying degrees of probability. Therefore, do not self-medicate, but consult a doctor who will select the most suitable remedy for you.
Forms of release and method of application
The most popular antifungal agent is Irunin tablets. Instructions for use tells us that the drug is a yellow round tablet, which should be used according to the specified scheme. With candidal vulvovaginitis - 0.2 g twice a day, with multi-colored lichen, the dosage can be halved. The same dose (0.2 g once a day) is preserved in the treatment of fungal keratitis, dermatomycosis. In some cases, it is recommended to reduce the dosage to 0.1 g per day. This is for diseases such as oral candidiasis and fungal skin lesions.
The second dosage form is the Irunin suppository. They are prescribed for thrush. The method of application is classic: daily, before bedtime, it is necessary to introduce one candle deep into the vagina. The duration of treatment is usually not more than two weeks. If you are already desperate to find a solution to a delicate problem, ask your doctor about the possibility of using the drug “Irunin”. Vaginal suppositories are very effective in controlling a disease such as candidiasis.
Overdose
To date, information about an overdose has not been reported even once. Nevertheless, it must be remembered that it is impossible to violate the regimen prescribed by the doctor, as well as to increase the dosage. If there is a suspicion of taking a large dose of the drug, you should rinse the stomach and give the person activated charcoal. There is no antidote, since the use of a high dose of the drug is not life threatening. Despite this, it is necessary to conduct general strengthening therapy.
How much is "Irunin"
Against the background of the advertised Diflucan and similar drugs, the price of Irunin is quite moderate. The cost of packing capsules of 0.1 mg is 330 rubles. One pack contains 14 capsules. In this case, candidiasis is treated by taking 0.2 g capsules twice (morning and evening) or for three days, one capsule of 0.2 mg per day. As you can see, the Irunin preparation is very affordable and economical. The price of the tablet does not exceed 30 rubles.
In the treatment of pityriasis, the pattern changes slightly, 200 mg is prescribed once a day, treatment lasts up to 7 days. The most difficult to treat diseases, such as aspergillosis, cryptococcosis, histoplasmosis, sporotrichosis, require a long course of two months to a year. In this case, the patient should not take more than 200 mg of the drug daily. But even in this case, treatment with Irunin is quite affordable. The price of the tablet comes out almost 10 times lower than the capsules of "Flucanosole", also often prescribed for thrush and other problems.
The drug "Orungal"
This is an original medicine, on the basis of which later they started to produce a variety of generics, that is, drugs that are created on the basis of clinical studies of its original progenitor. The lack of the need to invest time and money in long-term development allows manufacturers to maintain a more attractive price. We have already talked about how much Irunin costs. Now for comparison, let's look at the average prices for Orungal. For the same 14 capsules, you will give at least 2500 rubles, that is, at least five times more expensive.
It should be noted that there are three original antifungal drugs on the market . This is Orungal, which specializes in treating fungus of the skin covered with hair (it may be the head, chest or back); Lamisil - specializes in the treatment of nail fungus and is absolutely useless for the treatment of mucous membranes and internal organs - this is the scope of Diflucan. In turn, Orungal is also used to treat fungal infections of the oral cavity, vagina, intestines and bronchi.
Other analogues
Against the backdrop of all antifungal drugs on the market, Irunin is the most popular. Instructions for use, reviews of doctors and patients - all confirms the high effectiveness and reliability of the drug. It is very difficult to find another such a successful combination of price and quality on the market. In addition to the above analogues, doctors can offer you the drug "Itrazol", it is very close in cost and will cost about 400 rubles per package.
Another popular counterpart is Orungamine. The cost is about the same, as is the spectrum of action. The most reliable is the antifungal drug "Orungal", this is not the cheapest treatment option, but clinical studies confirm its highest effectiveness.
Drug interaction
How safe is it to start a course of treatment with other drugs if you are taking Irunin? The instruction (the price of this brand is the most attractive, therefore, we pay more attention to it) suggests that in some cases it will be necessary to interrupt the course if there is an urgent need to take other drugs. This applies to drugs such as rifampicin, rifabutin, diphenin. And the point is not that the interaction of these drugs with Irunin has a harmful effect on the body. These drugs activate liver enzymes, which in turn reduces the effectiveness of itraconazole.
There are also drugs that, on the contrary, enhance the effectiveness of the active substance “Irunina”. These are drugs such as erythromycin and ritonavir. In combination with antifungal drugs, you can not take such drugs as terfenadine and astemizole, chalcium and flormidal, quinidine, oral, zocor, lovastine, misolastine, cisaparide.
Pregnancy and lactation
During pregnancy, the threat of Candida fungus doubles. But precisely during this period, treatment with the Irunin preparation is strictly prohibited. They can not only negatively affect the fetus, but also cause severe malformations. Therefore, the expectant mother is offered supportive therapy with the help of folk remedies. During lactation, the baby’s body also receives all the medicines that the mother takes. Therefore, without serious reasons, you should not take any medications. This should be remembered by all women of reproductive age. If you are prescribed long-term treatment with such a serious drug, then you must definitely protect yourself with reliable means to avoid an accidental pregnancy. After completing the course of treatment, at least three months should pass before the time of pregnancy planning.