Tranexan has a local and systemic hemostatic effect in conditions accompanied by an increase in the amount of fibrinolysin (platelet pathology, menorrhagia). The medication is able to suppress the formation of kinins and other active peptides involved in inflammatory and allergic processes. Thus, Tranexan has anti-tumor, anti-infectious, anti-allergic and anti-inflammatory properties.
Excretion is carried out by the kidneys. If their function is impaired, cumulation (accumulation) of tranexamic acid may occur . The drug penetrates the blood-brain and placental barrier, is evenly distributed in the tissues. Concentration persists for seventeen hours. The maximum level of the drug in plasma is observed after three hours after oral administration.
Tranexan. Description of indications
As a hemostatic agent for bleeding or the likelihood of their development as a result of increased fibrinolysin during operations, in the postoperative period, with manual separation of the placenta, postpartum hemorrhage, chorionic detachment, malignant tumors of the prostate and pancreas, liver diseases, leukemia, bleeding during gestation.
With bleeding or the likelihood of their development against the background of a local increase in fibrinolysin with uterine, nosebleeds, as well as in the gastrointestinal tract. These conditions include hematuria, tooth extraction in patients with hemorrhagic diathesis.
The drug "Tranexan" instruction allows you to use as an anti-allergic agent for allergic dermatitis, urticaria, eczema, skin rash, provoked by toxins and drugs.
The medication is prescribed for stomatitis, laryngitis, pharyngitis, tonsillitis as anti-inflammatory therapy.
The drug is also used for hereditary angioedema .
Tranexan. Instructions for use
With an increase in local fibrinolysin, from 1 to 1.5 g are recommended three or four doses per day. With repeated bleeding from the nose - during the week, three doses of 1 g each. After extraction (extraction) of the tooth for six to eight days, three or four doses of 25 mg / kg of body weight. With profuse bleeding (uterine) - for twelve to fourteen days, three doses of 1.5 g each. Therapy for hereditary angioedema of 2-3 doses of 1-1.5 g continuously or courses under the supervision of a specialist.
Tranexan. Instructions for intravenous administration
The solution for injection is used drip, jet.
When local fibrinolysin is strengthened, 2-3 administrations of 250-500 mg are administered, and with an increase in general, every six to eight hours a single dose of 15 mg / kg at a speed of 1 ml / minute.
In operations for the bladder and for prostatectomy during the intervention, an injection of 1 g is carried out, then a gram every eight hours for three days. After that, they switch to taking the tablet form of the drug.
10 mg / kg is administered to patients with coagulation disorder before tooth extraction. After the extraction, tablets are prescribed.
In the presence of impaired renal function, a dosage conversion is necessary in accordance with the level of creatinine.
Tranexan. Instruction Side effects
Diarrhea, nausea, appetite disorder, vomiting, heartburn are noted from the gastrointestinal tract. Dizziness, drowsiness, impaired vision, color perception, weakness are manifested by the central nervous system. Pain in the chest, tachycardia, the development of thromboembolism, thrombosis and other reactions of the cardiovascular system are noted. With rapid administration, hypotension is likely to occur. The use of the drug also causes urticaria, skin rash, itching.
Tranexan. Instruction Contraindications
The drug is not prescribed for hypersensitivity to the components, with subarachnoid bleeding.