What are the analogues of Coraxan? You will find the answer to this question in the materials of this article. In addition, we will provide you with information about why such a drug is needed, how it should be taken, etc.
General drug information
Coraxan tablets are a drug that slows the heart rate. This medication contains in its composition such an active substance as ivabradine hydrochloride, as well as auxiliary components in the form of lactose monohydrate, magnesium stearate, corn starch, maltodextrin and colloidal silicon dioxide.
pharmachologic effect
Analogs of Coraxan, as well as the drug itself, regulate heart rate due to selective and specific inhibition of the IF channels of the sinus node, which also controls spontaneous diastolic depolarization. The active substance of this drug has an effect on the atrioventricular and intraventricular pathways, as well as on ventricular repolarization and myocardial contractility.
Among other things, ivabradine hydrochloride can interact with the IR channels of the retina, similar to cardiac IF channels, which are involved in the occurrence of a temporary change in visual perception. However, the main pharmacological feature of this substance is the ability to reduce heart rate.
Indications for the use of pharmacy
Why use the analogues of "Coraxan", as well as the tool itself? These drugs are prescribed in the following cases:
- Stable angina pectoris. Therapy of such a disease with this agent is carried out in patients with normal sinus rhythm in the presence of contraindications and intolerance to beta-blockers, as well as in combination with them.
- Heart failure (chronic). With this deviation, the drug itself and Coraxan analogues are used to reduce the incidence of cardiovascular complications. Indeed, a large mortality of patients is associated with such diseases.
Contraindications to the use of the drug "Coraxan"
Analogues of the drug "Coraxan" and the medication itself is not recommended for use in the following cases:
- hypersensitivity to ivabradine hydrochloride or any of the auxiliary components of the drug;
- unstable angina pectoris ;
- cardiogenic shock;
- bradycardia (that is, when the heart rate at rest is less than 60 beats per minute);
- myocardial infarction (acute);
- liver failure (severe);
- severe arterial hypotension (with arterial pressure less than 90 mm Hg. Art. and diastolic - less than 50 mm Hg. Art.);
- weak sinus node;
- the presence of a pacemaker;
- sinoatrial block;
- lactation and pregnancy;
- atrioventricular block of the 3rd degree;
- the simultaneous use of potent inhibitors of isoenzymes of the cytochrome system (for example, the drugs "Ketoconazole", "Erythromycin", "Itraconazole", "Josamycin", "Clarithromycin", "Ritonavir", "Telithromycin", "Nefazodon" and "Nelfinavir");
- minority (safety and effectiveness of the use of this drug until the age of 18 has not been studied);
- lactose intolerance.
Take with extreme caution!
Coraxan medication (price, analogues of this drug will be presented below) should be used only as directed by a doctor. With extreme caution, such tablets must be taken with:
- liver failure (moderate);
- lengthening of the QT interval (congenital);
- renal failure (severe);
- simultaneous administration of drugs that extend the QT interval;
- the simultaneous use of grapefruit juice and inhibitors of cytochrome isoenzymes;
- asymptomatic disruption of the left ventricle;
- atrioventricular blockade of the 2nd degree;
- stroke (recently transferred);
- retinal pigmentation (its degeneration);
- hypotension;
- at the same time taking calcium channel blockers (for example, the drug "Diltiazem" or "Verapamil").
The drug "Coraxan": instructions for use
Analogues of this tool suggest almost the same methods of application and dosage as the named medication. But before using them, be sure to read the attached instructions and consult a doctor.
- With stable angina, this drug in an initial dose is prescribed in an amount of 10 mg per day. If after 3-4 weeks the therapeutic effect has not occurred, the daily dosage should be increased to 15 mg per day.
- In chronic heart failure, such a drug in an initial dose is prescribed in an amount of 10 mg per day. If after 2 weeks the therapeutic effect has not occurred, the daily dosage should be increased to 15 mg per day.
- For patients over the age of 75, the recommended starting dose is 2.5 mg twice daily. In the future, you can increase the dose of the drug.
- In case of impaired renal function, patients are prescribed Coraxan in the amount of 10 mg per day. If after 3-4 weeks the therapeutic effect has not occurred, the daily dosage should be increased to 15 mg per day.
- In case of impaired liver function, patients are prescribed the drug "Coraxan" in an amount of 10 mg per day. If after 3-4 weeks the therapeutic effect has not occurred, the daily dosage should be increased to 15 mg per day.
Possible side effects after taking the medication
Despite the effectiveness, not everyone with heart problems is in a hurry to take this drug. First of all, this is due to the fact that he has many side effects:
- Blurred vision and frequent changes in light perception (or so-called photopsy).
- Bradycardia, sinus arrhythmia, ventricular extrasystole, angina pectoris (unstable), palpitations, myocardial infarction, arterial hypotension, supraventricular extrasystole, atrial fibrillation, ventricular tachycardia and myocardial ischemia.
- Diarrhea, nausea and constipation.
- Headaches (especially in the first month of treatment), dizziness, shortness of breath, muscle cramps, vertigo and fainting.
- Hyperuricemia and eosinophilia.
- Skin rash, angioedema, pruritus, urticaria and erythema.
- Asthenia, malaise and fatigue.
The drug "Coraxan": reviews, analogues of the drug
Those who have used this tool more than once respond only positively about it. However, such a drug is very expensive. So, for 56 tablets of the drug “Coraxan” you will have to give about 1200 Russian rubles. In this regard, most patients with heart diseases more often began to acquire cheaper analogues of the drug presented.
The following drugs can be attributed to the structural analogues of this drug for the active substance:
- "Ivabradine hydrochloride";
- "Ivabradin."
According to the therapeutic effect (drugs intended for the treatment of angina pectoris):
- Amlodipine;
- Asparkam
- "Atenolol";
- Aspirin Cardio
- Betalok;
- Validol
- "Hypoxene";
- "Isoket";
- Diltiazem
- Isolong
- Carvedilol
- "Concor";
- Corvitol;
- Lokren
- Cordipine;
- Corinfar Retard
- "Metoprolol";
- Mildronate
- "Monosan";
- "Nitroglycerine";
- "Papaverine";
- Nitrong
- Nifedipine
- "Normodipine";
- Plavix
- Prestance;
- "Stamlo";
- "Sustonite";
- "Trimetazidine";
- Tenox
- "Egilok";
- Efoks Long, etc.