The drug "Colchicine" is included in the group of alkaloids and other cytotoxic drugs of plant origin. The medicine has an antigout, analgesic effect. The drug has an anti-mitotic effect, inhibiting lympho- and leukopoiesis, reduces the utilization of glucose by non-phagocytic and phagocytic leukocytes, and prevents the formation of amyloid fibrils. The medication contributes to the violation of neuromuscular transmission, stimulation of the gastrointestinal tract. The drug has a depressing effect on the respiratory center, increases pressure, constricts blood vessels, lowers temperature. Absorption occurs from the digestive system quickly. The medicine undergoes enterohepatic recirculation. High concentrations of the drug are found in the spleen, liver and kidneys. The drug is excreted through the kidneys and with bile.
Medication "Colchicine." Instructions for use. Indications
The drug is prescribed for a gouty attack, to prevent the recurrence of acute gouty attacks, especially during the first two years after the start of receiving hypouricemic medicines. Indications include systemic scleroderma, Behcet's disease, amyloidosis, familial Mediterranean fever.
The medicine "Colchicine." Instructions for use. Side effect
On the basis of taking the medication, dyspeptic manifestations can be noted. In particular, nausea, diarrhea, vomiting, anorexia occurs. As a rule, such symptoms are characteristic of the condition after taking high doses. The negative consequences include temporary alopecia, an increase in the content of gamma-glutamyltranspeptidase and alkaline phosphatase, liver failure, and impaired renal activity. The drug can provoke myelosuppression (leukopenia, aplastic anemia, agranulocytosis, thrombocytopenia), myopathy, depression, reversible aspermia. During therapy, peripheral neuritis, allergic skin reactions, malabsorption syndrome, expressed, in particular, a lack of vitamin B12, are noted. With intravenous administration, local irritation occurs.
Means "Colchicine." Instructions for use. additional information
The medication is able to enhance the effect of sympathomimetic and depriminating drugs. Based on the application, there is a violation of the absorption of vitamin B 12. When combined with NSAIDs and other drugs that provoke myelodepression, the likelihood of thrombocytopenia and leukopenia increases. Cytostatic drugs can reduce the gout effect (uric acid content increases).
The drug "Colchicine." Instructions for use. Overdose
With drug poisoning, nausea, soreness in the mouth and abdomen, severe diarrhea, vomiting, hemorrhagic gastroenteritis are noted. An overdose condition is characterized by skin burning, decreased myocardial contractility, dehydration with hypovolemic shock and hypotension, hematuria, convulsions, respiratory depression, ascending paralysis, oliguria. The occurrence of hepatocellular damage, acute renal failure, and pulmonary infiltrates are likely. Five days after drug poisoning, inhibition of bone marrow with thrombocytopenia and leukopenia may begin . Treatment of patients in an overdose is carried out at a poison control center.
Means "Colchicine." Instruction Price
The cost of the medication is from 1450 rubles.