The drug "Propranolol" is a lipophilic blocker (non-selective) of beta-adrenergic receptors. The medicine helps to reduce the frequency and decrease the strength of the contractions of the heart, reduces the need for myocardial oxygen. The medication "Propranolol" has a membrane-stabilizing property. The medicine reduces the frequency of ectopic foci formation. Describing the therapeutic effect of Propranolol, the instructions for use indicate a negative inotropic and chronotropic effect. In other words, the frequency and strength of the contractions of the heart do not change. Stabilization of the hypotensive effect is noted towards the end of the second week of treatment.
Absorption of the drug from the digestive system occurs at 90%. In the liver, the drug is metabolized by almost 70%. The half-life of the drug is from three to six hours.
The drug "Propranolol". Instructions for use: purpose
The drug is recommended for arterial hypertension, hyperkinetic heart syndrome, tachyarrhythmia, coronary heart disease, essential tremor. As a prophylaxis, Propranolol is prescribed for migraines. The medicine is also indicated for symptomatic therapy of hyperthyroidism.
The drug "Propranolol". Instructions for use: dosage regimen
The medicine "Propranolol" (release form - tablets) is recommended for oral administration before meals for ten to fifteen minutes. The therapeutic dosage is ten to twenty milligrams. Take the drug two to four times a day.
Gradually (in accordance with the noted therapeutic effect), the dosage is increased to forty milligrams from four to six times a day.
In the form of a solution for injection, the drug "Propranolol" is prescribed for the treatment of cardiac arrhythmias. The dosage regimen is set by the doctor.
Contraindications
The drug "Propranolol" instruction does not allow to appoint for heart failure (decompensated), cardiogenic shock, bradycardia, severe arterial hypotension. Contraindications also include bronchial asthma, COPD, a disorder in the peripheral circulation, hypersensitivity to the drug.
Side effects when using the propranolol agent include dyspeptic symptoms, numbness and a cooling sensation in the extremities, dizziness, fatigue, and headache. In addition, when taking the drug, sleep disturbance, the development of depression is possible. Side effects also include cramps and muscle weakness, decreased lacrimation, hypoglycemia, impaired potency, hallucinations, and dry mouth. In rare cases, keratoconjunctivitis may occur. Probably also the appearance of angina attacks, visual disturbances.
special instructions
Patients with pheochromocytoma are recommended the simultaneous administration of alpha-adrenergic receptor blockers.
Caution should be exercised when using the drug "Propranolol" in patients with diabetes mellitus or during fasting.
It was found that the medication is able to influence psychophysical functions, weaken attention, slow down the response. In particular, these phenomena are noted with the simultaneous intake of alcohol or drugs that depress the action of the central nervous system.
The drug is able to penetrate the placental barrier. There have been no studies on the use of propranolol in the first trimester of pregnancy. The drug must be discontinued in the pregnant woman 48-72 hours before the probable term of delivery, in order to prevent respiratory depression, hypoglycemia, arterial hypotension and bradycardia in the newborn. A born child should be observed by a doctor for two to three days.
Before using the drug "Propranolol", you should consult with a specialist and carefully study the annotation.