The drug "Clomiphene Citrate" is an oral estrogen antagonist, part of the group of non-steroidal drugs. As a result of using this medication, the secretion of LH and FSH of the anterior pituitary gland is significantly increased, and maturation and subsequent growth of follicles are stimulated. Due to this effect, Clomiphene Citrate is prescribed, as a rule, to increase the ability to bear children in female patients. In this case, it excellently stimulates ovulation, while blocking the action of estrogen in the body. In addition, it should be noted that this agent does not have androgenic or gestagenic activity, and in large doses it can inhibit the secretion of gonadotropins. In this case, the so-called half-life of the drug "Clomiphene Citrate" is about five to seven days.
This oral non-steroidal drug is available in the form of conventional
medicinal tablets of white color. A substance such as clomiphene acts as the main component. It is it that effectively reduces the ability of steroid hormones to bind to the corresponding receptors.
The instruction recommends taking Clomiphene Citrate tablets for the treatment of anovulatory infertility in women. This drug also helps with dysfunctional uterine bleeding. Women who suffer from secondary, dysgonadotropic, or post-contraceptive amenorrhea should also start taking this drug, an estrogen antagonist. The list of main indications for its appointment, in addition to all of the above, also includes polycystic ovary, androgen deficiency and Chiari-Frommel syndrome. Patients with established galactorrhea, which developed against the background of a pituitary tumor, are also quite often prescribed Clomiphene Citrate tablets. Reviews also note the positive results of their administration in oligospermia. And, finally, this drug is actively used to diagnose disorders of the so-called gonadotropic function of the brain appendage - the pituitary gland.
This remedy should not be categorically prescribed if the patient has an increased individual sensitivity to clomiphene, as well as in case of uterine bleeding of an unclear etiology. In addition, it is necessary to refrain from taking the drug in question in severe hepatic or renal failure. A tumor or ovarian cyst is also a reason for refusing
prescribing Clomiphene Citrate tablets. They are never taken during pregnancy.
In conclusion, it should be said about the main side effects that can be caused by taking the drug. For example, some women may experience headaches, insomnia, dizziness, increased anxiety, depression, and fatigue. In addition, there is a risk of visual impairment, cystic ovarian enlargement, the development of pollakiuria, dysmenorrhea or polyuria, as well as weight gain.