Instructions for use helps to get acquainted with the drug "Creon 25000". But even written by specialist pharmacologists, it will not replace consultations with your doctor. All descriptions of medicines are for guidance only, and despite the clarity and ease of reporting, they are in no way a guide to self-medication.
Indications for use "Creon 25000" is an extensive list of a variety of ailments. It is prescribed for pancreatic diseases for replacement therapy with insufficiency of its exocrine function in the following conditions: pancreatectomy, cystic fibrosis, chronic pancreatitis, Schwachman-Diamond syndrome. The drug "Creon 25000" is prescribed for ductal obstruction that appears with neoplasms (an example is obstruction of the common bile duct or pancreatic ducts), with a diagnosis of pancreatic cancer, in cases of decreased enzyme-forming gastrointestinal function in the elderly.
Additionally, this drug can be prescribed for symptomatic therapy in case of digestive disorders, in a number of cases associated with past diseases. For example, after cholecystectomy, partial resection of the stomach, with total gastrectomy, exacerbation of symptoms of duodeno- and gastrostasis, biliary obstruction, cirrhosis, pathology of the small intestine in the terminal region, with excessive bacterial growth in the small intestine, cholestatic hepatitis.
The pharmacological effect of the drug "Creon 25000", based on its enzymatic properties, improves digestive processes. The composition includes pancreatic enzymes, they facilitate the digestion of fats, proteins, carbohydrates. As a result, they are completely absorbed.
In one capsule of the drug is 300 mg of pancreatin. The units of the following components are ED EF. Amylase amounts to 18000, limpase 25000 and protease 1000. Excipients are macrogol, liquid paraffin, dimethicone, methylhydroxypropyl cellulose phthalate, dibutyl phthalate.
For the shell, iron oxide red and yellow, gelatin and titanium dioxide are used.
The dosage form of the preparation "Creon 25000" is represented by a gelatin capsule, which contains enteric-soluble minimicrospheres. Capsules tend to dissolve rapidly in the stomach, releasing hundreds of minimicrospheres. Using the principle of a multi-unit dose allows their mixing with the contents of the intestine, which leads to a better distribution of enzymes after they are released from the capsule. When the small intestine reaches the small microspheres, the intestinal-soluble membrane is destroyed, pancreatic enzymes are released, leading to the disintegration of starch molecules, fats and lipids.
When using "Creon 25000" patient reviews note the high effectiveness of the drug. But sometimes adverse reactions were observed. The digestive system reacted rarely with diarrhea, but most often with constipation, discomfort in the stomach, and sometimes nausea appeared.
But in addition to numerous positive properties, there is a list of diseases in which the use of "Creon 25000" must be abandoned. These are acute pancreatitis and exacerbation of chronic pancreatitis, a manifestation of hypersensitivity to the drug and its components and in the event of allergic reactions.
In case of an overdose, hyperuricuria and hyperuricemia are possible.
And although the drug is dispensed in pharmacies without a prescription, before its use and even during its use, consultation and supervision by a doctor are necessary.
For storage of drugs, choose a place inaccessible to children. When packing it in blisters, the storage temperature should not exceed 20 ° C. If the drug is in HDPE bottles, the storage temperature should not exceed 25 ° C with a tightly sealed lid. For any form of release, an expiration date of two years is provided. Three years is stored "Creon 25000", which is packaged in bottles of HDPE.