Gastrointestinal tract diseases are a human problem in the modern world. People are forced to treat physicians tormenting their pains in the abdomen, and those, in turn, prescribe them various procedures and medications. "Creon 10000" is prescribed to patients more often than many other medicines. Sometimes it may seem that this drug is the solution to all problems associated with the digestive system. This article will answer the most frequently asked questions about the "Creon 10000".
The composition and form of production
The instructions for use with "Creon 10000" says that it is available in gelatin, hard capsules, which dissolve in the intestines. They are divided into two halves: one is brown opaque, the other is colorless, transparent. Capsules contain small granules of light brown color. Twenty, fifty or one hundred capsules are packaged in plastic bottles.
In the instructions for use, "Creon 10000" in tablets is not described.
Active component
The instructions for use with "Creon 10000" say that the active substance of the medication is pancreatin. One capsule contains one hundred and fifty mg of the active ingredient, corresponding to the content of the following number of units:
- lipase - 10000;
- amylase - 8000;
- protease - 600.
Pharmacodynamics
The instructions for the use of capsules "Creon 10000" says that the drug contains enzymes pacreatin. It is a substance that improves digestion, namely:
- removes symptoms of digestive enzyme deficiency,
- normalizes the digestion of beneficial substances, because of which they are completely absorbed in the small intestine.
The "Creon 10000" contains pancreatin of porcine origin. When it enters the stomach with food, the capsule shell disintegrates, releasing hundreds of microgranules. A similar form is designed so that the granules are mixed with the contents of the intestine and passed through the gastrointestinal tract with food. As soon as the microbeads enter the intestines, the capsule shell is rapidly destroyed, enzymes are released. Substances produced by cleavage are absorbed or cleaved further in the intestine.
Pharmacokinetics
The instructions for use of the drug "Creon 10000" says that its therapeutic activity is realized in the lumen of the gastrointestinal tract. By structure, pancreatitis enzymes are proteins. When passing through the digestive tract, they are split into amino acids and peptides.
Drug use
In the instructions for use of "Creon 10000", it is written that it can be used for alternative therapy of digestive enzyme deficiency due to a decrease in its activity due to production dysfunctions and transport of pancreatitis enzymes or because of their too much destruction in the intestinal lumen caused by various diseases digestive system.
According to the instructions for use, "Creon 10000" is most often prescribed in the following situations:
- recovery after an attack of pancreatitis;
- chronic pancreatitis;
- damage to the endocrine glands;
- pancreatic underdevelopment;
- partial removal of the stomach;
- breakage of the ducts of the gland under the stomach or bile duct;
- malignant tumors on the gland under the stomach;
- postoperative pancreatic repair;
- recovery after extirpation of the stomach;
- preparation for hardware examination of the abdominal cavity.
Sometimes a medication is recommended in case of a malfunction in the diet or a sedentary lifestyle, even for patients with a well-functioning digestive system.
Disclaimer
The use of "Creon 10000" according to the instructions is contraindicated in case of personal sensitivity to its components. It is not recommended to take medication for an acute attack of pancreatitis.
Method and dosage of administration
CREON 10000 capsules are taken orally during or after a meal. They must be consumed whole, washed down with the required amount of water. If a person has problems swallowing, then the capsule can be opened and added to food that does not require chewing (mashed potatoes, yogurt, juices and drinks). Food with the addition of "Creon 10000" is not subject to long-term storage, so it should be consumed immediately. It is not recommended to mix the contents of "Creon 10000" with hot food.
According to the instructions for use, the dosage of "Creon 10000" is selected individually for each patient, taking into account the symptoms, the severity of the disease, diet, diet and body weight of the patient. In case of genetic diseases, at the beginning of therapy, adults and children from four years old are prescribed 500 units / kg, for children under four years of age - 1000 units / kg with each meal. Based on the symptoms of the disease, the dosage can be reduced or increased according to the doctor’s recommendations.
For many patients, the dosage per day of Creon according to the instructions for use is 10,000 units / kg body weight or 4,000 units / g of consumed fat. For other diseases accompanied by a lack of digestive enzymes, the dosage is determined based on the personal characteristics of the person, containing the degree of insufficiency of digestion of food and the content of fatty foods in the nutrition structure. With the main food intake, as a rule, a dose of 25,000-8,000 units of lipase is necessary, with snacks - half the therapeutic dose.
According to the instructions for use, the dosage of "Creon 10000" for children is used in accordance with the recommendations of the doctor.
Side effects
Side effects are possible, according to the instructions for use of "Creon 10000", in adults from the digestive system:
- pain in the abdomen;
- bloating;
- fibrosis of the submucosal layer of the colon with the formation of its strictures.
Sometimes there are negative effects on the part of the skin in the form of a rash, urticaria and itching.
Side effects are possible in the form of anaphylactic reactions and from the exchange of beneficial elements with prolonged use of the drug in too high doses in the form of an increase in the level of uric acid in the patient's blood plasma.
According to the instructions for use of "Creon 10000", in children when using the drug in high doses, the following may occur:
- inflammation of the skin around the anus,
- indigestion
- diarrhea and pain in the abdomen,
- allergic reactions from the skin.
According to the instructions for use, for children "Creon 10000" is prescribed only by the attending physician.
Excess drug
An overdose can occur as an increase in uric acid in the blood. Then the drug is canceled and the therapy is replaced depending on the symptoms.
special instructions
If a patient while taking “Creon 10000" chewed, but did not swallow a capsule, then pancreatin enzymes will be released in the oral cavity. This can, firstly, cause irritation of the oral mucosa, and, secondly, reduce the effectiveness of the active substance. A similar situation can also occur when mixing the drug with food or drinks with an acidity level above 5.5. It is recommended to avoid negative side effects, when using the contents of the capsules "Creon 10000" without a shell, rinse the mouth thoroughly after taking the medication.
During treatment with Creon 10000, it is important to provide the patient with a sufficient amount of fluid to drink on an ongoing basis, especially with its excessive loss (vomiting, diarrhea). Due to the low fluid intake the patient may develop constipation.
"Creon 10000" doctors do not recommend taking during an exacerbation of pancreatitis. Patients with a pancreatic genetic disease who are taking high doses of pancreatin are likely to have strictures in the colon. It is worth remembering that the dose should be comparable to the amount of enzymes required for the absorption of fats and should not be more than 10,000 units / kg per day.
If negative symptoms appear, it is recommended to conduct an examination, especially in patients using Creon 10000 in doses exceeding 10,000 units / kg per day. Digestive disorders can occur in patients with personal hypersensitivity to the active substance "Creon 10000".
According to the instructions, "Creon 10000" does not affect the ability to adequately drive a vehicle. There is no tangible negative impact on the ability to work with complex apparatuses and to perform functions that require concentration and speed of reactions.
Application for carrying a child and natural feeding
Clinical studies in animals did not reveal a negative effect on the reproductive functions and development of the unborn child. To date, there is no data on therapy with drugs containing digestive enzymes of animal origin, women in a state of pregnancy, so they are prescribed a medication with caution. According to the instructions for use, "Creon 10000" during pregnancy is prescribed if the benefits of treatment exceed potential negative risks. In this condition, women should be careful when taking drugs.
Similarly, no harmful effects are expected, according to the instructions for use of "Creon 10000", for infants through mother's milk. The medication can be used during the period of natural feeding.
Use in children
Irregular or loose stools, gas, food allergies are all signs of an upset digestive system. As a rule, this problem occurs in toddlers and young children. The causes of the disorders are as follows:
- adverse environmental conditions;
- regular nervous breakdowns in children due to complex relationships in the environment of the child;
- weak muscle structure;
- enzyme deficiency.
Children begin to eat poorly, it is not enough to put on weight, complain to mothers about abdominal cramps and a feeling of heaviness after eating. According to reviews and instructions for use for children, "Creon 10000" in this case is an indispensable drug. It normalizes the digestive processes in the body, because the structure of the drug contains those enzymes that take an active part in such activities. The rational enzymatic composition of the drug helps to digest the incoming food, ensuring the normal absorption of these beneficial substances. Pills "Creon 10000" stimulate the production of enzymes by the pancreas.
According to reviews and instructions for the use of "Creon 10000" by children, the drug can be taken by small patients subject to the dosing regimen. In children, the likelihood of constipation increases with a high activity of the lipase contained in the enzyme, so the dosage should be increased in stages.
Interaction with other drugs
An analysis of the interaction of pancreatin with other medicines was not conducted in a clinical setting. We list the main points that you need to pay attention to:
- Pancreatin may reduce the absorption of concomitant iron supplements.
- The drug may decrease the effectiveness of acarbose.
- Drugs intended for the treatment of gastrointestinal diseases by neutralizing hydrochloric acid can reduce the effectiveness of pancreatin.
Storage conditions
According to the instructions for use, "Creon 10000" tablets must be kept in an airtight vial, out of the reach of small children, at a temperature of up to 25 ° C. Shelf life - two years, after the initial opening of the bottle - three months. A drug without a prescription is dispensed from pharmacies.
Reviews
Many doctors prescribe "Creon 10000" to treat the deficiency of digestive enzymes in the body in children, because they believe that only symptomatic treatment is not enough. According to the results of the analysis of feces, after taking a course of medication, as a rule:
- significantly reduced amount of undigested food residue in the stool,
- the quality of the chair improves
- skin becomes clean.
Reviews about "Creon 10000" from patients are usually very positive:
- there is an improvement in the general condition of the patient after a few days of therapy;
- emphasizes the normalization of digestion and stool, the disappearance of pain and discomfort in the abdomen and sides, nausea after eating.
Many patients take it on their own and advise other people to use this medication as an ambulance for malnutrition. Despite the fact that there are many other drugs, including an order of magnitude cheaper, patients do not recommend rushing to replace Creon 10000 with other medicines, since they believe that the analogues are not effective enough compared to the described drug.
It is worth mentioning that there are negative reviews about the “Creon 10000" from people in whom it caused negative effects.
Analogues of the drug
Preparations similar in action, analogues of "Creon 10000" are:
- "Gastenorm forte" and "Gastenorm forte 10000". Drugs are available in tablets. They are indicated for pancreatic diseases affecting its main function: pancreatitis, cystic fibrosis.
- "Creon 25000."
- Mezim and Mikrazim. Medicines are made in capsules.
- "Pangrol 25000." German medication available in capsules. He performs replacement therapy for exocrine pancreatic insufficiency in adults and children.
- Pancreasim The medication is made in tablets. Not applicable for cystic fibrosis.
- Pancreatin An agent that promotes the digestion of the contents of the stomach, including enzymatic agents. The drug is available in tablets and dragees.
- Pancreatin forte. Pills to restore disorders of exocrine pancreatic function, accompanied by digestive upset.
- Penzital. Indian enzyme drug designed to normalize digestion. It is available in tablets.
- Enzistal-P. An enzyme medication that improves digestive processes. The drug contains digestive enzymes that break down beneficial elements, contributing to their full absorption in the small intestine.
- Hermitage. Digestive enzyme agent in capsules with a different dosage of active substances of the pancreas. The active component of the drug is pancreatin.
Stomach problems are a modern human problem. Improper nutrition, an unadjusted meal schedule - all this leads to digestion, discomfort in the pancreas or the stomach itself after eating. Quickly get rid of the problem will help "Creon 10000". Varieties of the drug "Creon 10000" and "Creon 25000" are dispensed in a pharmacy without a prescription.