High blood pressure is an indicator of over 120/80. If it exceeds both values or only one (upper or lower), you need to take some measures to stabilize it. Otherwise, unpleasant consequences develop, in extreme situations even a fatal outcome is possible. Medicines can lower blood pressure.
The reasons for the increase in blood pressure are diverse. For a short time it rises after physical exertion, taking coffee, tea, alcohol, and also with the use of certain medications. After a short period of time, the level stabilizes. At high pressure, as a rule, tablets "Iruzid" help well. Some patients are looking for the drug Izurid, but such a medication does not exist. Its trade name is "Iruzid." It is this medicine that can be purchased at pharmacies. Consider the instructions for its use, as well as the most effective analogues.
Drug characteristics
"Iruzide" is a complex drug with antihypertensive as well as diuretic effects. The drug is available in tablet form. Active substances are lisinopril and hydrochlorothiazide.
Each pill is biconvex. Their color depends on the dosage:
- Blue. Lisinopril and hydrochlorothiazide are contained in amounts of 10 and 12.5 milligrams, respectively.
- Light pink. The active substances in the pill are 20 and 25 mg.
- Yellow. Dosage - 20 and 12.5 mg.
The tablets are packed in blisters of thirty pieces. In a pack, as a rule, one blister.
What are the medicinal properties of the medicine
"Iruzide" from pressure is considered a hypotensive complex drug. It has a diuretic and antihypertensive effect. The active substances have an additive antihypertensive property. It begins to appear after about six hours, the effect persists for a day. The duration of the positive effect also depends on the concentration of the drug.
The effect of high blood pressure is observed in the first day after the start of therapy. The condition stabilizes in most patients after one to two months. With the abrupt cancellation of the Iruzid tablets from pressure, a marked increase in this indicator is not observed. In addition to lowering blood pressure, lisinopril also reduces the appearance of protein in urine (albuminuria).
With hyperglycemia, the use of Iruzid tablets helps to stabilize the functions of the damaged glomerular lump. Lysinopril does not affect the blood glucose level in patients with diabetes mellitus. In addition, this substance does not provoke the occurrence of hypoglycemia.
Hydrochlorothiazide is a thiazide diuretic. Its effect is associated with a violation of the reverse absorption of potassium, chlorine ions, as well as water in the far neuron. The occurrence of hypotensive effects is provided due to the expansion of small arteries. It has antihypertensive effects, delays the elimination of uric acid and calcium.
It has practically no effect on stable blood pressure. The occurrence of urinary effects is observed after about a couple of hours, reaches a maximum concentration after four hours. The duration of the positive effect varies from six to twelve hours, which is indicated in the reviews for the drug "Iruzid 10/12, 5" and in the instructions. A drug with a different dosage has approximately the same indicators.
Many patients report that it may take three to four weeks to achieve the optimal pharmacological effect.
Lisinopril is absorbed from the stomach and intestines quickly, absorption from eating does not depend and is thirty percent. The maximum concentration reaches eight hours after the use of the drug.
When a medication is prescribed
According to the instructions for use, Irusid tablets are prescribed to eliminate high blood pressure if there are indications for the implementation of complex treatment.
Limitations
The drug should not be used in the presence of the following conditions and ailments:
- Anuria (a pathological condition that is provoked by various diseases, the symptom of which is the cessation of urine into the bladder).
- Severe renal failure.
- Angioneurotic edema (an acute condition characterized by the rapid appearance of local edema of the mucous membrane, as well as subcutaneous tissue and the skin itself).
- Hypercalcemia (increased plasma calcium).
- Hyponatremia (a disease in which the concentration of sodium ions in the blood decreases below normal).
- Porphyria (congenital lesion, which is accompanied by a violation of the metabolism and structure of hemoglobin).
- Precoma (a serious disease for a patient's life that precedes a coma).
- Age to eighteen.
- Lactation.
- Individual intolerance to the substances that make up the drug.
- Primary hyperaldosteronism (the result of the production of aldosterone in the glomerular layer of the adrenal cortex).
- Hypertrophic cardiomyopathy (autosomal dominant disease, which is characterized by hypertrophy of the wall of the left or, in rare cases, the right ventricle).
- Aortic stenosis (narrowing of the aortic opening in the valve area, which makes it difficult for blood to escape from the left ventricle).
- Artery stenosis of a single kidney (a disease that contributes to clogging of the carotid artery with a thrombus or atherosclerotic plaque, the main cause of ischemic stroke).
- Bilateral renal artery stenosis (narrowing of the lumen of the vessel, which is provoked by congenital pathologies, as well as atherosclerosis and inflammatory changes).
- Conditions after a kidney transplant.
- Bone marrow hypoplasia (a condition in which myeloid tissue is replaced by adipose tissue).
- Arterial hypotension (a common pathological disease that manifests itself as a constant, as well as persistent tonometer indicator below the standard level).
- Hypovolemic conditions (a pathological process that is caused by a rapid decrease in the volume of circulating blood).
- Hyponatremia (a disease in which the content of sodium ions in the blood falls below normal).
- Diabetes mellitus (a group of thyroid diseases that develop due to a deficiency or lack of insulin in the body, resulting in a significant increase in blood glucose).
- Systemic lupus erythematosus (a serious pathological condition in which the own immune system perceives the cells of the human body as strangers).
- Deterioration of bone marrow hematopoiesis.
- Gout (a chronic metabolic lesion characterized by metabolic disorders and the inability of the kidneys to excrete uric acid).
- Hyperkalemia (a pathological condition that provokes an abnormally high content of potassium in the blood).
- Hyperuricemia (a disease in which the level of uric acid in the blood exceeds the limit).
- Cerebrovascular ailments (a group of diseases of the brain that are caused by pathologies of cerebral capillaries with impaired microcirculation of the brain).
- Coronary heart disease (organic and functional damage to the muscles of the heart, which is provoked by a deficiency or termination of myocardial microcirculation).
How to take the drug
In the reviews and instructions for use with "Iruzid" it is reported that the medication is taken orally. As a rule, doctors recommend one tablet (10 / 12.5 mg or 20 / 12.5 mg, in some cases 20/25 mg) once a day. If the use of "Iruzide" is prescribed for kidney diseases, the initial dosage should be from 5-10 milligrams of lisinopril.
Secondary arterial hypotension may occur after consuming the initial dosage of “Iruzide”. As a rule, such situations are observed in people who have had a loss of electrolytes and fluids due to the previous use of diuretics. In this regard, before using the drug "Iruzid" for two to three days, treatment with diuretics is stopped.
Side effects of "Iruzida"
According to the instructions for the drug, during its administration, such negative reactions can be observed:
- Headache.
- Anorexia (a neuropsychic disorder, which manifests itself in an intense desire for weight loss, as well as a fear of fullness).
- Jaundice (staining of the skin and visible mucous membranes in yellow, due to the increased content of bilirubin in the blood and tissues).
- Dizziness.
- Pancreatitis (an inflammatory lesion of the pancreas).
- Cholestatic or hepatocellular hepatitis (a common form of malignant neoplasm in the liver).
- Diarrhea.
- Tachycardia (heart palpitations).
- Photosensitivity (increasing the body's sensitivity to ultraviolet or visible radiation).
- Orthostatic hypotension (a disease that is characterized by a sharp decrease in blood pressure with a change in body position).
- Bradycardia (slow heart rate).
- Violation of atrioventricular conduction (the time during which the electrical impulse produced by the sinoatrial node reaches the working ventricular myocardium through the conduction system of the heart).
- Urticaria (a disease of an allergic or toxic nature, which manifests itself in the form of pinpoint red spots).
- Bronchospasm (a pathology that occurs when the smooth muscles of the bronchi are contracted and their lumen is reduced).
- Violation of respiratory rate.
- Impaired attention span.
- Mood swings.
- Paresthesia (a secondary disease in which the sensitivity of the skin and mucous membranes is impaired, which develops against the background of irritation of nerve endings).
Overdose
According to the reviews for the medicine, “Iruzide”, if used incorrectly, can provoke the following reactions:
- Fatigue.
- Asthenic syndrome (a psychopathological disease that is characterized by progressive development and accompanies most diseases of the body).
- Oliguria (decrease in the amount of allocated urine compared to the norm).
- Anuria (a pathological condition that is provoked by various causes. A symptom of the disease is the cessation of urine into the bladder).
- Uremia (an acute or chronic disease that occurs with severe renal damage due to a delay in the body's nitrogenous metabolic products and other toxic substances).
- Anemia (a condition of the human body characterized by a reduced concentration of hemoglobin per unit volume of blood).
- Erythrocytopenia (low red blood cell count per unit blood volume).
- Leukopenia (low white blood cell count in the general cellular composition of the blood).
- Thrombocytopenia (a pathological condition characterized by a decrease in the number of blood clots circulating in the peripheral blood).
- Agranulocytosis (a pathology in which a decrease in the level of leukocytes due to granulocytes and monocytes is observed).
- Neutropenia (low level of neutrophilic granulocytes in the general cellular composition of the blood).
- Hypochloremia (a decrease in the concentration of chlorine minerals in the blood).
- Hyperglycemia (a pathological condition that is accompanied by diabetes mellitus of the first and second types, and is also characterized by a significant increase in sugar level).
- Hyperuricemia (a disease in which the level of uric acid in the blood exceeds the norm).
- Hypokalemia (decreased potassium concentration).
- Hyperkalemia (a pathological condition that provokes an abnormally high content of potassium in the blood).
- Hypomagnesemia (a disease in which a small amount of magnesium is contained in the human body).
- Hyponatremia (a pathology based on a decrease in the content of sodium ions in the blood).
- Hyperbilirubinemia (a pathological disease of blood serum, which manifests itself in an increase in bilirubin content).
- Hypertriglyceridemia (increased plasma triglycerides).
- Hypercholesterolemia (a pathological condition in which there is an abnormal increase in blood cholesterol).
- Hypercalcemia (increased plasma calcium concentration).
- Renovascular hypertension.
- Eosinophilia (a condition in which there is an absolute or relative increase in the number of eosinophils).
- Itching
- Vasculitis (autoimmune inflammation of the vessel wall, in which any vessels of different calibers can be affected: arterioles, veins, arteries, venules).
- Fever.
Generics
According to reviews, the analogues of "Iruzida 10 / 12.5" are:
- Lysoretic.
- "Co-Diroton."
- Lisinopril.
- "Liten N."
- "Rileys-Sanovel plus."
- Lister Plus.
- "Sinorezid".
- Scopril Plus.
- "Zoniksem NL".
It is necessary to store the drug at temperatures up to plus twenty-five degrees. This medication is prescribed by a doctor’s prescription.
Next, the most effective analogues of "Iruzida 10 / 12.5" will be considered.
"Co-Diroton"
A complex drug that has a diuretic as well as antihypertensive effect. It is used to normalize blood pressure.
The occurrence of the antihypertensive effect after taking the drug begins after about six hours and persists for a day. The medication has about the same composition as "Iruzid". The active substances in it are lisinopril and hydrochlorothiazide. The difference is in the auxiliary products used in the production, which do not have a therapeutic effect.
“Co-Diroton” - an analogue of “Iruzid 20 / 12.5" - begins to influence in about an hour, the maximum content is noted after seven hours. The effect of the component with high blood pressure is observed on the first day after the start of therapy, the occurrence of a stable effect can be noted after two months.
An intense increase in blood pressure with a sharp cessation of "Co-Diroton" is not observed. In addition to lowering blood pressure, lisinopril helps reduce albuminuria. In patients with hyperglycemia, the function of the disturbed glomerular endothelium is stabilized. The active substance does not affect the concentration of glucose in the blood in patients with diabetes mellitus.
From the reviews and instructions for the analogue “Iruzida 20 / 12.5” it is known that the most pronounced decrease in blood pressure is observed with a decrease in the volume of fluid, which is provoked by the use of diuretics, a decrease in salt in food, dialysis, as well as diarrhea or vomiting.
In people with chronic heart disease (without kidney failure), an intense decrease in blood pressure is likely. As a rule, it is detected in patients with severe diseases of the heart and blood vessels after taking diuretics in high concentrations.
Therapy in such people must begin under the strict supervision of a doctor. Similar recommendations should be followed when prescribing "Co-Diroton" to patients suffering from cardiac ischemia, as well as cerebrovascular insufficiency, since a sharp decrease in blood pressure can cause the appearance of myocardial infarction or stroke. Transient blood hypotension is not a limitation for further treatment.
If possible, normalize the sodium content and replenish the volume of fluid before therapy. In this case, careful monitoring of the effect of the initial dosage of the drug on the patient's health is shown. In chronic heart diseases, a marked decrease in blood pressure after the start of treatment with angiotensin-converting enzyme inhibitors can lead to further deterioration of the kidneys.
Studying reviews of the analogue of “Iruzid” (we are talking about “Co-Diroton”), one can come across reports of cases of acute kidney damage. While taking ACE inhibitors in people with bilateral narrowing of the renal arteries, an increase in serum urea and creatinine was noted. Typically, this disorder occurs in patients suffering from renal failure. In such situations, the medicine should be stopped and established to monitor human health.
Lisinopril
Tablets belong to the therapeutic group of antihypertensive drugs. They are used to lower high blood pressure in various pathological processes of the heart and blood vessels.
According to the instructions for the analogue of "Iruzida 10 / 12.5", this effect of the drug leads to the appearance of a number of biological effects:
- Reducing the total resistance to blood flow present in the vascular system of the body.
- Lower blood pressure.
- Reduce the severity of the load on the heart.
- Pressure reduction in the pulmonary circulation.
- To increase the resistance of the heart to stress, especially in people with heart failure.
As written in the instructions for use with the analogue of "Iruzide", "Lisinopril" to a greater extent expands the capillaries, rather than veins. Prolonged use of the medication helps to reduce pathological expansion of the heart muscle, improve myocardial nutrition. In addition, the drug prolongs the life of people who have suffered coronary heart disease.
After using the tablet, the orally active component is absorbed into the blood from the intestine in an incomplete volume. It evenly spreads through the tissues, practically does not pass through the placental barrier into the fetus during pregnancy. The drug is not exchanged in the body, it is excreted by the kidneys with urine. The elimination half-life is twelve hours.
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- A decrease in the functional activity of the kidneys in acute myocardium is considered a ban on taking the drug.
- The use of a medication for renal artery stenosis can lead to a significant decrease in the functional activity of the kidneys.
"Sinorezid"
This is a comprehensive antihypertensive drug that has antihypertensive and diuretic effects. Active ingredients - lisinopril and hydrochlorothiazide. The first disrupts the transformation of angiotensin one into biologically active angiotensin two, which increases peripheral vascular tone and also helps the adrenal glands to produce aldosterone.
The drug reduces the general peripheral resistance of capillaries, blood pressure, reduces the load, as well as pressure in the pulmonary vessels, provokes an increase in the minute volume of blood. The medication contributes to the expansion of arteries to a greater extent than veins.
Certain effects are explained by the effect on the human hormonal system, which regulates blood pressure and blood volume. With prolonged use, it reduces the intensity of the increase in the muscles of the heart and arterial walls. Improves myocardial microcirculation. Angiotensin-converting enzyme inhibitors prolong the life of people with heart disease, as well as slow down the further development of left ventricular disorders in patients after myocardial infarction.
"Sinorezid" begins to act one hour after consumption, reaches a maximum concentration after about seven hours, the duration of the effect is 24 hours. At high pressure, the pharmacological effect can be observed on the first day of treatment, but stabilization of blood pressure occurs after one to two months.
Hydrochlorothiazide is a thiazide diuretic whose diuretic effect is associated with a violation of the reverse absorption of chlorine ions, as well as potassium and magnesium.
This component of the drug inhibits the excretion of calcium, as well as uric acid. It has an antihypertensive effect. The antihypertensive effect occurs due to the expansion of capillaries. Absolutely does not change normal blood pressure. The diuretic effect occurs two hours after ingestion, reaches a maximum after four hours and lasts about twelve hours.
When used together, two active substances (lisinopril and hydrochlorothiazide) have an additive effect that reduces pressure.
When taking "Sinorezid" a strong decrease in blood pressure, as a rule, appears with a decrease in the volume of circulating blood, provoked by treatment with diuretic drugs.
In chronic heart diseases, an intensive decrease in blood pressure after the start of the use of angiotensin-converting enzyme inhibitors can lead to impaired renal function. When using the medication, situations of acute renal failure were noted.
Lysoretic
This is an antihypertensive drug, which, with the help of the constituent substances, also has a diuretic effect.
According to the instructions for use with the analogue of "Iruzide", the drug is widely used for high pressure therapy and is dispensed by doctor's prescription.
Lysoretic is an effective drug whose active components are lisinopril and hydrochlorothiazide.
The medication enters into drug interactions, has certain prohibitions and adverse reactions, it is contraindicated during the "interesting situation" and when breastfeeding.
Patient opinions
According to reviews, "Iruzid" is considered an effective tool in situations where complex treatment is indicated. It is noted that blood pressure drops sharply, but after proper dosage selection, the medication is well tolerated by patients.
Many write that at the beginning of treatment they are scared by an impressive list of contraindications and side effects. However, nothing bad happens if you take the tablets, observing the dosage prescribed by your doctor.
Some people lament that the drug cannot be bought at pharmacies without a prescription. But this is correct, as uncontrolled intake of pills can only do much harm.
The cost of the drug varies from 400 to 700 rubles.