Type 2 diabetes mellitus - the disease is very dangerous. If untreated, with such an ailment, patients may eventually come in a coma. Of course, many drugs have been developed to treat this disease. And, perhaps, the most effective of all these funds today is Yanumet. The analogues of this medicine for the most part have earned not so good reviews from patients and doctors.
Composition and form of release
The peculiarity of this medicine is, first of all, that it contains two active substances that complement each other at once. The main therapeutic component of this drug is metformin hydrochloride. The medicine "Yanumet" is available in the form of tablets. That is, it should be taken orally. Metformin in the composition of one such tablet may include 500, 850 or 1000 mg.
The second active ingredient of Yanumet is sitagliptin. This ingredient, regardless of the content of metformin hydrochloride, is always included in the amount of 50 mg in one tablet. Both active substances of the drug are able to effectively control the blood sugar level of the patient.
Of course, as with any other pill, the composition of "Yanumet" includes auxiliary ingredients. But not one of them has a therapeutic effect on the patient’s body.
In the manufacture of tablets of this drug are coated, having, of course, a fairly complex chemical composition. Thanks to this form of release, the Yanumet tablets do not have any harmful effect on the gastric mucosa of patients.
What is metformin hydrochloride?
The benefit of this substance for patients with type 2 diabetes mellitus is, first of all, that when it enters the body, it reduces:
This component of Yanumet and analogues of this drug with a similar composition is able to increase the sensitivity of cells to insulin through the capture and utilization of glucose. Many inexpensive substitutes for this drug, belonging to the group of mono-drugs, are made on the basis of just metformin as an active substance.
How does sitagliptin
This second active substance of Yanumet in the body of a patient with type 2 diabetes inhibits the enzyme DPP-4, which leads to an increase in the concentration of the active hormones GLP-1 and HIP, which are responsible for self-regulation of glucose. The activity of DPP-4 when taking patients "Yanumeta" is suppressed for about 24 hours. In comparison with metformin, sitagliptin is considered to be a slightly less dangerous substance for the patient’s body in terms of side effects. Monopreparations intended to control the blood sugar level in patients with diabetes are also often made on its basis.
Additional substances
In addition to metformin hydrochloride and sitagliptin, the composition of Yanumet includes such auxiliary components as:
The shell of these tablets contains, among other things, polyvinyl alcohol, titanium dioxide, talc, black and red iron oxide, macrogol. If a patient with diabetes is allergic to any of these substances, you may need to refuse to take Yanumet.
The most effective analogues
The price of Yanumet tablets depends primarily on the amount of metformin hydrochloride included in their composition. This medicine comes from the Netherlands (with packaging in Russia), unfortunately, is quite expensive. For example, the packing of tablets "Yanumet" in the amount of 56 pcs. at a dosage of 500 mg will cost the patient, depending on the region, 2500-3000 p. Therefore, many people with type 2 diabetes, of course, are interested in including whether this medicine has cheaper analogues.
Unfortunately, preparations with the same composition as Yanumet are not yet produced in Russia. Most foreign substitutes are not inferior in price to this tool. The only analogue synonym for the drug “Yanumet”, sold at a lower price, in Russia at the moment is “Galvus Met”.
The most effective substitute for this drug with the same composition is currently considered Velmetia. Those who are looking for an analogue of Yanumet 1000 + 50 mg, for example, should pay attention primarily to this drug.
Also, in some cases, this medicine may be replaced by:
"Combogliz Prolong."
"Gentadueto."
For these analogues of Yanumet, the instructions for use are provided for almost the same as for this drug itself. However, these drugs have a slightly different composition. Therefore, control of sugar with their use can be carried out according to other schemes. In any case, it is worth changing the "Yanumet" to these drugs, as, indeed, to any other analogues, on the recommendation of a doctor.
Also, in some cases, “Janumet” can be replaced by a combination of two less expensive drugs - “Januvia” (Netherlands) and “Glucophage”, which is an original metformin.
The medicine "Galvus Met"
This drug belongs to the category of “Yanumet” group analogues. 1000 to 50 mg is one of its common dosages. One of the main active ingredients in it is also metformin. But instead of sitagliptin, vildagliptin is included in its composition in an amount of 50 mg. A month of treatment with this drug will cost a patient with diabetes about 1600 p. This medicine is also available in tablets and is intended for oral administration.
Metformin is also included in the composition of the analogues of Yanumet, Combogliz Prolonga and Gentadueto. In this case, the first medicine additionally contains saxagliptin, and the second - linagliptin.
Analog "Velmetia"
This medicine is produced by the well-known manufacturer in Russia, Berlin-Chemie. It is made mainly at the enterprises of Italy and Spain. The main active ingredients of this drug, like Yanumet itself, are metformin and sitagliptin. Moreover, such a medicine is supplied to the market in two dosages: 850 + 50 mg and 1000 + 50. In Russia, the Velmetia analogue of Yanumet, unfortunately, can only be purchased on order. In addition, this medicine is also very expensive.
Cheap substitutes
In Russia, analogues of Yanumet 1000 + 50 mg, 850 + 50 mg, etc., thus, there are several. But all such drugs, which are essentially synonymous with this medicine (since they have the same or similar composition), unfortunately, are expensive. However, cheap analogues of this medicine, made on the basis of other components or in another way, for example, domestic production in pharmacies, of course, are also available. In most cases, judging by the reviews of patients, they lower blood sugar somewhat worse than the expensive Yanumet, which was developed taking into account the latest scientific achievements. But still, such drugs for diabetes, of course, can be very useful.
For example, the following drugs can be attributed to the group of inexpensive analogues of the Yanumet drug:
"Diabeton."
Glidiab.
Diabetalong.
"Gliclada", etc.
Such drugs are often prescribed to people with diabetes by doctors. Many patients consider all these domestic analogues of Yanumet to be quite effective.
Indications for use
The drug “Yanumet” is prescribed by doctors for patients with diabetes quite often. Of course, this medicine, like any other similar ones, in therapy is only an addition to the diet and exercise regimen specially developed for the patient. It is especially effective if the person’s disease is accompanied by obesity.
Quite often, doctors prescribe patients with type 2 diabetes mellitus “Janumet” in combination with other drugs. For example, in many cases it is combined with sulfonylurea derivatives, PPAR agonists, and with insulin.
Contraindications
This modern medicine is prescribed, like any other, of course, not all patients can. When can’t you use the drug “Yanumet” to control blood sugar levels according to the instructions and analogues 1000 + 50 mg, 500 + 50 mg, 850 + 50 mg of this medication? Such drugs are not prescribed, of course, to those patients who have hypersensitivity to their two main or any auxiliary components. It is also believed that you can not take such drugs in patients with acute conditions that can adversely affect kidney function:
shock;
with severe infections.
Doctors prescribe diabetes patients "Yanumet" and some of its analogues in chronic or acute diseases leading to tissue hypoxia:
In no case should you take this drug for intoxication, for example, with alcohol. Of course, this applies to any analogues of the Yanumet medicine. Along with alcohol, as you know, it is strictly forbidden to take almost any medication, with the exception of sorbents.
Also, "Yanumet" is not prescribed for:
acidosis;
impaired renal function.
You can not drink this medicine to patients during the period of radiological studies if they were injected with iodine-containing contrast agents. It is forbidden to take this drug 48 hours before the procedure and 48 hours after it.
With type 1 diabetes mellitus, this remedy does not have any beneficial effect on the patient's body. Therefore, in this case, of course, it is also not prescribed to patients. Like many of its analogues and substitutes, "Yanumet" is not prescribed for patients under the age of 18 years. Children's age is one of the contraindications for this medication.
Can I use during pregnancy and lactation
Unfortunately, since the Yanumet preparation is still quite new, it has not been studied in terms of a possible negative effect on the bearing fetus. No data are currently available on its safety for pregnant women and their unborn children. Therefore, like almost any other blood sugar control agent, Yanumet is contraindicated for use during the period of bearing a child. This drug is also not prescribed for lactating women.
In what cases should be taken with caution
Both main active ingredients of Yanumet and analogues of this drug of the same composition are excreted through the kidneys. As you know, with age, the activity of this organ in humans decreases. Therefore, the drug "Yanumet" for older people should be prescribed with caution. The doctor must choose the dosage for such a patient very carefully. Also, the treatment of elderly patients with type 2 diabetes should be carried out exclusively under the supervision of a specialist. Renal function in such patients should be monitored regularly.
Elderly patients are supposed to write “Yanumet” only after checking the kidneys and confirming that this body performs its function well. Otherwise, such a patient is very likely to experience serious side effects when taking Yanumet. Of course, with caution, this drug should be prescribed to young patients who have any kidney problems.
What side effects can cause
This drug is carried by people with diabetes, judging by the reviews of patients and doctors, it is usually very good. Side effects in their treatment are rare. They usually occur with the same frequency as with complex therapy with metformin with placebo. But, of course, like any other drug, Yanumet and analogues of this drug with a similar composition can in some cases have a negative effect on the patient’s body.
At the very beginning of treatment with such drugs, patients sometimes experience side effects from the gastrointestinal tract. This may be, for example, nausea, vomiting, diarrhea. Also, many patients note the appearance of a metallic taste in the mouth when taking Yanumet. Sometimes this remedy also causes flatulence and abdominal pain. The latter is usually reduced during meals.
On the part of the cardiovascular system, anemia may occur in patients treated with this drug. This is primarily due to the fact that the absorption of folic acid and vitamin B12 is impaired in the body of the patient taking Yanumet.
Also, during treatment with this drug in patients, side effects such as:
drowsiness and weakness;
respiratory disorders;
hypotension;
abdominal pain.
In some cases, this medicine may cause a rash on the patient’s body.
How to use
How to drink this medicine according to the instructions? Analogues of Yanumet with the same or similar composition as this drug itself, most often patients take once or twice a day with food. To avoid side effects, the dose of this medicine is supposed to be increased to the necessary gradually. Doctors recommend whole swallowing Yanumet tablets. To achieve maximum effect, they are not allowed to break, crush or chew.
In some cases, tablets of this drug may not be completely digested in the digestive tract. If their remains are regularly found in feces, it is imperative to inform the attending physician about this. After this, the doctor should check the effectiveness of glycemic control using this tool.
What dosages are provided
Of course, you should take strictly according to the instructions "Yanumet" and analogues of 1000 + 50 mg, 500 + 50 mg, 850 + 50 mg of this drug, as well as any others. The amount of Yanumet medicine that the patient needs to drink should, of course, be determined solely by the doctor. Typically, the initial dose of this drug is 500 mg of metformin + 50 mg of sitagliptin twice a day.
Quite often, "Janumet" is prescribed to those patients who are not helped by monopreparations containing only one of these substances. In this case, the initial dosage should be prescribed in accordance with certain rules. In the absence of the control effect of metformin, for example, at first the patient is prescribed “Janumet” in such an amount that he takes no more than 100 mg of sitagliptin per day.
In the event that before treatment with Yanumet the patient was treated with sitagliptin, he was recommended a dose equivalent to 500 mg metformirn + 50 mg sitagliptin 2 times a day. Of course, for this drug, as for any other, there are maximum allowable dosages. It is believed that patients with type 2 diabetes should not take this drug in amounts of more than 2000 mg of metformin and 100 mg of sitagliptin.
Overdose
It is, of course, necessary to take this medicine in exactly the same way as the attending physician prescribed. Overdoses of Yanumet cannot be tolerated. Sitagliptin, even in sufficiently large quantities, does not usually cause particular harm to the human body. For example, it was found that a dose of 800 mg of this substance by people is well tolerated. Unfortunately, it is not known how a greater amount of sitagliptin affects the human body, since such studies have not been conducted.
In this case, it is believed that an overdose of metformin, unfortunately, is still possible. In this case, the patient may develop hypoglycemia. Also, overdoses of metformin lead to the development of lactic acidosis. Unfortunately, this happens quite often - in 32% of cases.
Lactic acidosis is called a very dangerous complication, in which the acid-base balance is disturbed in the human body. In severe forms, this pathological condition becomes, among other things, the cause of heart failure. Subsequently, lactic acidosis can lead to collapse and anurea, and then to hyperlactacidemic coma.
Help with lactic acidosis
In the event of such a complication, measures to save the patient must be taken very quickly. Help the patient with lactic acidosis by intravenously introducing 4% or 2.5% sodium bicarbonate solution. The maximum dose of this drug is considered to be 2000 ml per day. In addition, with lactic acidosis, “short” insulin therapy can be used to treat patients, using craboxylase preparations, reopoiliglukin solution, blood plasma, and heparin.
How dangerous lactic acidosis can be can be seen below in the photo. “Janumet” and analogues of this medicine with the same or different composition must be taken, of course, exclusively at the dosages at which the doctor recommended it.
What drugs can weaken the effect of taking "Yanumet"
Some types of drugs at the same time with this drug is not recommended. To weaken the effect of this agent (metformin) can, for example:
Among other things, it is believed that Yanumet itself is able to change the effect of certain drugs on the patient’s body. These include, for example:
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"Furosemide";
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"Cyclosporin."
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There are practically no shortcomings in this drug, judging by the reviews of people with diabetes. Perhaps the only drawback of this medicine, according to patients, is its high cost. Unfortunately, not all people in need can take this drug, unfortunately.
Reviews of doctors about the drug
Doctors, like the patients themselves, consider Yanumet a very effective medicine. Doctors prescribe it to their patients with type 2 diabetes, often enough. In addition to the effectiveness of the action, specialists, like the patients themselves, also relate to the undoubted advantages of this drug that it, unlike many other similar drugs, rarely causes various kinds of side effects. That is why from many doctors on the Web there are very good reviews about Yanumet. Analogues and substitutes for this medicine on the patient’s body, according to doctors, often have much more negative effects. Transfer to Yanumet from other medicines for this reason, doctors of their patients quite often.
Due to the fact that this medicine does not have any significant effect on the development of, for example, hypoglycemic syndrome, it, of course, also earned good reviews from doctors. Analogues of "Yanumet" are inexpensive to take in this regard have to be more careful.
Despite the fact that the medicine is almost completely safe, specialists nevertheless do not advise to self-medicate using this tool. Dosages of this drug should be selected exclusively by doctors. Only in this case, the medication will not have a harmful effect on the patient's body and will work as efficiently as possible.
How to store
In pharmacies "Yanumet" and analogues of this drug, both domestic and foreign, in most cases are sold exclusively by prescription. Of course, in order for this medicine to work effectively if it is necessary to control the level of sugar in the blood, it, among other things, must be properly stored. Keep this medicine, like most other drugs, should be in a dark place. It is believed that Yanumet preserves its properties only if the ambient temperature does not rise above +25 ° C. Therefore, in the summertime on very hot days, such tablets may need to be refrigerated.
Of course, you need to store this drug in such a way that children or, for example, pets cannot access it. The shelf life of the medicine "Yanumet" is 2 years from the date of issue. After this time, such a medication is not allowed to use to control blood sugar levels. After 2 years from the date of release, the medicine should be disposed of.