With vaginosis, which is triggered by Candida's yeast-like fungus, doctors usually prescribe Clotrimazole or Pimafucin. Doctors consider them the most effective in this situation. But in order to determine which is more effective, it is necessary to study in detail the composition of each drug, as well as the spectrum of action and other features. What is better "Pimafucin" or "Clotrimazole" for thrush?
The properties
The effectiveness of therapy with a particular medication depends on the characteristics of the body and the severity of the fungal infection. What is Pimafucin from?
In the body, fungi can appear in large numbers, which sometimes exceeds the permissible level. It is difficult to cope without pharmacological treatment. Specialized drugs help to significantly reduce their number. But along with this, you must follow a diet, as well as hygiene rules and other advice of a medical specialist.
In order for the elimination of the fungus to be the most effective, in addition to drug treatment, the diet should be adjusted.
One of the frequent indications for the use of "Clotrimazole" and "Pimafucin" is considered candidiasis. This is a fungal disease that appears in the absence of hygiene as a result of chronic infections. Candidiasis happens:
Both drugs are based on imidazole and polyene antimicrobials. The substances of the preparations help not so much the inhibition of fungal activity as they do not allow the fungus to spread further. They are used in the treatment of fungal infections of the vagina, male penis, skin integument.
If we are talking about sexual diseases, then when one person is infected, both partners should undergo therapy. What is Pimafucin from? The active substances of the two medicines are different. The active microelement "Pimafucin" is natamycin, and in the second preparation - clotrimazole.
"Clotrimazole" is not suitable for general use, since it is immediately excreted from the body.
"Clotrimazole"
According to the instructions for use, Clotrimazole tablets appeared in the seventies of the last century. The active component disrupts the cell membrane of the fungus and key substances come out of it, which helps to eliminate fungal cells. The drug affects various pathogens:
- Candida fungi;
- staphylococci;
- streptococci.
Candida fungi are most susceptible to the drug. Clinical studies have confirmed that it is a safe and effective remedy for thrush.
According to the instructions for use, Clotrimazole tablets are not suitable for systemic treatment, since the drug is removed from the body almost immediately, and an increase in dosage can provoke intoxication of the body.
Pimafucin
The active ingredient is natamycin, it is considered a natural antimicrobial substance. "Pimafucin" refers to antifungal drugs that are produced by actinobacteria. Its effect is directed to ergosterol, with which the trace element binds, as a result of which prevents the growth of fungal elements.
Natamycin is not absorbed by the mucous cavities of the gastrointestinal tract; addiction to it does not appear with prolonged use of the medication.
"Pimafucin" eliminates such fungi:
- nail;
- vaginal;
- cutaneous;
- urethral.
A comparison of Clotrimazole and Pimafucin is based on the following statements.
Both drugs belong to the same therapeutic group - antifungal drugs. They differ in active substances. The medication based on natamycin has the following forms:
- vaginal suppositories;
- ointment;
- capsules.
The second drug has more dosage forms. These are gel, cream, ointment, suppositories, vaginal tablets, solution for external application, granules and powder. Both drugs were created to eliminate fungal infections.
What are the similar medicines
Pimafucin and Clotrimazole have the following similar characteristics:
- They are used to treat candidiasis and other fungal diseases in both mild and severe forms.
- They are released from pharmacy points without a prescription.
- Different forms of release.
Both the one and the other drug belong to the same therapeutic group.
What is the difference between "Clotrimazole" and "Pimafucin"
In addition to similar aspects, there are certain differences between the drugs. These include:
- Natamycin acts more gently and practically does not penetrate the blood when applied.
- "Pimafucin" can be used throughout pregnancy in the absence of sensitivity to substances, the second drug can be used in the second and third trimester.
The composition of "Pimafucin" and "Clotrimazole" includes different active substances. "Pimafucin" acts softer, during use, the drug practically does not penetrate the blood. Clotrimazole does not have a release form in tablets for oral use.
The indications for taking the two medicines are also different, but not significantly, the possible adverse reactions also differ.
The cost of drugs is also different, but here the differences depend largely on the manufacturer. What is the instruction for use and price of Pimafucin and Clotrimazole?
Russian-made drugs are much cheaper than foreign ones, but have a similar effect. "Pimafucin" - from 200 to 700 rubles, "Clotrimazole" - from 20 to 260 rubles.
Which is cheaper
The price and instructions for use with "Pimafucin" "Clotrimazole" depends on the manufacturer. For example, a foreign-made Clotrimazole cream can cost up to two hundred rubles, and an ointment with that name from a domestic manufacturer is slightly cheaper. Another medicine in the form of a cream will cost more.
The differences relate to the cost of the drug for vaginal use. For example, vaginal tablets "Clotrimazole" cost about fifty rubles, and suppositories with a different name - up to five hundred rubles.
Which is better: "Clotrimazole" or "Pimafucin"
The pharmacological effect and the effect of the drug on healthy organs largely depends on how the body reacts to the substances of a particular drug. It is also necessary to consider whether patients have other diseases or pathological processes in which it is not recommended to use both medicines, or it is possible, but under the strict supervision of a doctor.
With candidiasis
Both he and the other medication are recommended for thrush. But it’s difficult to determine exactly what works more efficiently. The impact depends on the form in which the disease occurs - acute or recurring, whether a person suffers from diabetes and other diseases.
With vaginal candidiasis, as a rule, local therapy is prescribed: suppositories, vaginal tablets, ointments.
If a woman is diagnosed with thrush, then she is prescribed local antifungal medications: suppositories, tablets, creams or ointments. In other situations, the decision is made by a medical specialist individually.
From actinomycosis (fungal infection)
When choosing a liniment from a skin fungus, one should take into account the characteristics of the body and the prohibitions on applying this or that medication. Among them are both considered drugs. They are best affected by the treatment of yeast infections in the arms, legs and body.
Ointment "Clotrimazole" is considered to be a representative of the pharmacological group of antifungal drugs for external use. They are used for treatment, which is aimed at eliminating the source of the infectious process caused by drug-sensitive pathogens.
Its antifungal effect is to inhibit the growth and spread of fungal cells and their subsequent elimination due to impaired formation of ergosterol, which is the main component of the fungal cell wall.
This leads to a change in permeability, with its subsequent elimination and death of the fungal cell. In small concentrations, Clotrimazole inhibits the growth and reproduction of the fungus, at a higher dosage it leads to the destruction and death of the fungal cell.
In a large dosage, the active component of the drug provokes a change in the metabolic processes in the mitochondria of fungal cells with an increase in the intracellular level of hydrogen peroxide. The medication has an increased activity against yeast and mold fungi, as well as dermatophytes, sources of pink lichen and erythrasma.
Cream "Pimafucin" refers to local antifungal drugs.
Liniment is an antimycotic antimicrobial agent with a wide range of effects. Under the influence of the active substance, the growth and spread of fungi and other pathogens that are sensitive to Natamycin are suppressed. The drug destroys the membrane of the fungus, gets inside and provokes the death of the pathological element.
The most sensitive to the drug are yeast-like fungi of the genus Candida, the least sensitive are dermatophytes.
Information on the use of the drug among children under the age of one year is not available, therefore, before treatment, you should always consult with a medical specialist. Which is better: "Clotrimazole" or "Pimafucin"?
When eliminating vaginal candidiasis in women, it is best to simultaneously undergo a course of therapy and its sexual partner, otherwise the disease will be transmitted to each other. During treatment with "Pimafucin" fungal lesions of the genitals, it is necessary to refrain from intimacy.
During pregnancy
For women during an “interesting situation”, specialists usually recommend these medicines for treatment and for prophylactic purposes to prevent thrush in the form of creams, vaginal suppositories or ointments.
But it must be borne in mind that Pimafucin should be used in all trimesters of pregnancy, and the second medication only in the second and third trimester. In addition, suppositories can be prescribed before birth to reduce the risk of a baby's fungal disease when passing through the birth canal. It is difficult to determine exactly which is better: Clotrimazole or Pimafucin - both drugs are effective in their own way.
For women
Women use drugs in any form, as a rule, for the purpose of therapy and prevention of candidiasis and other fungal infections. Especially for women, a medication in the form of vaginal suppositories has been developed.
For men
Both drugs are prescribed for men to prevent candidiasis balanoposthitis. With proper therapy, the disease completely disappears in fourteen days. When applying Pimafucin cream, itching and burning are reduced after a few days, the symptoms completely disappear within ten days. When using a second medication, they go away much faster - in about seven days.