The drug "Prestance" (tablets) is a fixed combination of two well-known drugs "Amlodipine" and "Prestarium A". Today, according to experts, this tool is one of the most effective. This antihypertensive combination allows not only effectively, but also safely, in an adequate time to lower blood pressure in patients with varying degrees of arterial hypertension.
According to the manufacturer, the drug Prestance is successfully used in more than thirty countries of the world.
Both substances in the composition of the drug restore the elasticity and softness of the vessel wall. The drug thus prevents the development of stroke and heart attack. Along with this, studies have proven good tolerability of the drug. The manufacturer claims that after taking the drug there is no swelling, headache, cough, which is explained by the properties of the active substances.
The medicine is available in four combinations. So, the drug "Prestance" 10/5, 5/5, 10/10, 5/10 is produced. In combination, the first digit indicates the content of perindopril arginine (the drug "Prestarium A"), and the second - amlodipine benzylate. Dosage is in milligrams.
The drug "Prestans" recommended for use in patients with IHD and arterial hypertension.
Perindopril, which is part of it, is used in the treatment of high blood pressure of varying severity. When taking the drug, a decrease in both systolic and diastolic pressure is noted. Perindopril helps to reduce the total peripheral resistance in the vessels, this leads to a decrease in blood pressure, as well as an improvement in peripheral blood supply without changes in the heart rate. When taking the drug, increased renal blood flow. Moreover, the glomerular filtration rate is constant.
The active component of perindopril has a vasodilating property, helps to reduce hypertrophy in the left ventricle.
The antihypertensive effect of Prestans (instructions for use indicates this) reaches a therapeutic maximum after a single dose after 4-6 hours and lasts at least a day. In this case, a decrease in blood pressure is noted almost immediately after administration.
Persistent therapeutic effect is observed after a month from the first use. In this case, the patient's condition is not accompanied by tachycardia. Upon termination of treatment, withdrawal syndrome is not noted.
The amlodipine component inhibits the transmembrane transition to smooth muscle cells in the walls of blood vessels and cardiomyocytes of calcium ions. The substance has a direct effect on smooth muscle cells. The ability of amlodipine to provoke the expansion of peripheral arterioles, reducing total peripheral vascular resistance, has been proven. In this case, heart rate remains unchanged, and the need for myocardial oxygen does not increase.
Contraindications to the use of the Prestance medicine include instructions on the use of hereditary lactose intolerance, glucose-galactose malabsorption, lactase deficiency, up to eighteen years of age, renal failure, and hypersensitivity to the components. The drug is not prescribed for severe arterial hypotension, a history of angioedema, unstable angina, obstruction of the exit path in the left ventricle.
The drug "Prestans" instructions for use prohibits the appointment during pregnancy.
The medicine is usually prescribed as a tablet once a day. It is advisable to take the remedy in the morning, before breakfast. The dosage of the drug is set individually.
Before using the drug "Prestance" you need to consult a doctor.