St. John's wort herb is a unique herbal component of many medicines. Since ancient times, infusions and decoctions of it in combination with other substances have been popular in the treatment of depression, anxiety, and sleep problems. "Negrustin", with instructions for use and reviews to which you can find in this article, is a combined drug. He owes his action to the main active ingredient - St. John's wort herb extract.
Composition and form of release
The drug is available in two forms:
- gelatin capsules;
- solution for making a drink.
The main active ingredient of the drug is the dehydrated extract of St. John's wort herb. This concept means that the squeeze from the leaves and stems of the plant was subjected to a special treatment, after which it did not lose its healing properties.
Capsules "Negrustin" have an anti-anxiety, sedative effect. Effective in various kinds of pathologies of the nervous system, which are not provoked by traumatic brain injuries or organic lesions, but have psychological reasons.
St. John's wort extract is also able to reduce the toxic effect on neurons. For example, during the period of withdrawal and hangover, taking the drug can prevent the death of nerve cells. This affects the patient’s well-being in such a way that he is able to sleep soundly: in some cases, it helps prevent the development of delirium tremens and a psychotic state.
Indications for use
Instructions for Negrustin (patient reviews confirm its effectiveness) report that the drug is effective in the following diseases, mental disorders and conditions of the nervous system:
- weakness, asthenia, low energy levels for everyday activities;
- the period of a hangover and withdrawal syndrome;
- premenstrual period in women;
- depressive and anxiety disorders;
- manic-depressive psychoses;
- acute psychotic conditions (as part of complex therapy);
- motor restlessness, tremor of limbs;
- bulimia and nervous overeating;
- attention deficit hyperactivity disorder.
Reviews on Negrustin report that the therapeutic effect of taking the capsules comes faster than when taking the medicine in the form of a liquid. This result is due to the fact that the capsules are better absorbed by the body and have a more prolonged effect.
Side effects
Reviews of "Negrustin" report that in some cases, the drug can provoke the development of the following side effects:
- on the part of the nervous system: delayed reaction, drowsiness, feeling of depression and fatigue (especially in the first week of taking the capsules, this condition may occur, but from the second or third week of taking it leaves);
- from the organs of the gastrointestinal tract: indigestion, pain in the epigastric region, diarrhea or, on the contrary, constipation;
- from the endocrine system: St. John's wort can inhibit the release of calcium metabolites, which in rare cases can cause the development of hypercalcemia.
Most often, such symptoms occur in the first week of admission. when it appears, you can try to reduce the dose. For example, instead of two capsules, start taking one - side effects should go away.
Reviews of Negrustin report that some patients have developed such a side effect as a decrease in appetite. At the same time, St. John's wort itself has no effect on the areas of the brain responsible for satiation.
Neurologists attribute this effect to the fact that overeating often has psychosomatic causes. And sedative pills bring the nervous system and psyche in a relative order. After this, the patient no longer wants to seize up his nervous state and stress. Young girls are usually prone to "seizing" problems, and this can lead to the development of bulimia.
Contraindications
There are a number of absolute contraindications for taking capsules based on St. John's wort extract:
- chronic renal failure;
- liver diseases (fibrosis, cirrhosis, toxic hepatitis);
- severe forms of depression (the advisability of the reception is decided by the attending psychiatrist);
- psychotic conditions in which the patient is inadequate and threatens himself or others;
- taking MAO inhibitors;
- taking some psychotropic drugs (barbiturates, benzodiazepines).
Reviews of Negrustin report that some patients nevertheless ventured to take the drug in parallel with tranquilizer treatment. Such a combination is contraindicated and cannot enhance the therapeutic effect of drugs. Patients in their reviews noted that in addition to severe drowsiness, jumps in blood pressure, dizziness and asthenia, no improvement was noticed. Thus, “Negrustin” in combination with other sedatives does not make sense.
Drug interaction
Instructions for use with Negrustin reports that co-administration with MAO inhibitors, benzodiazepine tranquilizers, and barbiturates is prohibited.
With the simultaneous administration of SSRIs with antidepressants, the side effects of the latter intensify.
With the simultaneous administration of “Negrustin” with “Amitriptyline”, “Cyclosporine”, “Theophylline”, a reduction in the absorption of the active components of the former is possible.
Parallel administration of capsules based on St. John's wort extract with oral contraceptives can cause uterine bleeding.
special instructions
Almost all patients, having seen that the main active component of Negrostin - St. John's wort grass, do not take it seriously. Only people with a medical education realize that this is a very serious component that causes a number of side effects and is not compatible with many drugs.
At therapy "Negrustinum" it is not necessary to be in a sunlight for a long time. Long-term use of St. John's wort enhances the sensitivity of the epidermis to ultraviolet light. Reviews of Negrustin patients confirm that sunburns are much easier to get while taking the drug.
If the patient has fructose intolerance, care should be taken when taking the drug.
The effect of the agent on the ability to drive vehicles and operate precise mechanisms may be noted, especially if Negrustin was taken simultaneously with alcohol or other tranquilizers. A double sedative effect on the cells of the nervous system leads to the fact that a person gives a delayed reaction, can fall into a deep and prolonged sleep.
If the drug was used simultaneously with alcohol, the development of the so-called alcoholic coma is possible. In appearance it is a deep sleep during which the patient’s breathing is almost inaudible and the pulse is poorly felt. in fact - this is a kind of coma, which was provoked by a double intake of the strongest sedatives - ethanol and St. John's wort.
Cost and terms of leave from pharmacies
Reviews about the drug "Negrustin" confirm that the tool can be easily found on sale in any region of our country. It is possible to purchase it, both in private pharmacies, and in network points of sale of medicines (for example, "Healthy City").
The cost of one package is from five hundred rubles and more. The price may vary, depending on the region of the place of purchase and the margin of the pharmacy chain. To buy the drug does not require a prescription from a doctor.
Reviews when applying for insomnia
Reviews on Negrustin tablets for insomnia are different. About half of those taking it were able to establish a little sleep, it became easier to fall asleep. The other half of the patients are completely dissatisfied with the effect of the drug, regretted the money spent and called the effect of St. John's wort “fictitious”.
This variation in opinion is obvious. After all, the causes of insomnia are very different. If sleep problems are caused by endocrine disorders, an imbalance of hormones and neurotransmitters, other treatment will be required, and there will be little sense in taking capsules with hypericum. Hence the abundance of negative reviews: “Negrustin” was simply powerless.
Reviews on the use of depression
Instructions for use with the drug warns that Negrustin is powerless with endogenous causes of depression. It is also undesirable to take it during a period of psychosis provoked by depressive states. For this, more serious pharmaceuticals are needed (for example, benzidiazepine tranquilizers).
Doctors' comments about Negrustin indicate that the drug can have a therapeutic effect in any form of depression at the initial stage of their development. If the condition has been tormenting the patient for years, and he only recently went to the doctor, antidepressants of the SSRI group, antipsychotics, nootropics and, in some cases, normotics will be required. Negrostin can be combined with all these medicines only with the approval of the attending psychiatrist.
Reviews of neuropathologists about Negrustin report that the drug has an excellent effect, first of all, on people who are suspicious, prone to hypochondria. especially effective for the elderly and the elderly in the treatment of mild neurological disorders.
Analogs and substitutes: instructions for use
Reviews of analogues report that the drug is much more effective than its substitutes in the form of dry ground grass. It can be purchased at any pharmacy, and it costs about a hundred rubles. The main analogue of the drug is St. John's wort in powdered dry form.
Doctors associate this effect with a placebo - patients taking capsules with St. John's wort are sure that the drug has a strong therapeutic effect. And when taking a decoction of St. John's wort, it seems to them that this is just another folk remedy without a serious pharmacological effect. Also perceived "Negrustin." Instructions for use, reviews, analogues - all this confirms.
List of effective analogues
Among other medicines with St. John's wort, the following analogues of Negrustin can be distinguished (reviews of which report a noticeable therapeutic effect):
- "Deprim" - sold in capsule form. The cost of packaging is about three hundred rubles. To buy the drug does not require a prescription from a doctor. Effective for anxiety, sleep problems, constant anxiety and dysphoria.
- "Gelarium Hypericum" - a drug that is produced in Germany. It is prescribed to patients with increased nervous excitability, irritability. It can be used as part of complex therapy with antidepressants and tranquilizers of the benzodiazepine series.
- "Herbion Hypericum" is an antidepressant that contains only herbal ingredients. It is safe for prolonged use and does not cause drug dependence.