The drug "Clarithromycin" is an antibiotic from the group of semi-synthetic macrolides of the 3rd generation. Able to inhibit protein synthesis. In this article you will learn useful information about the drug "Clarithromycin" - analogues, indications and contraindications, possible side effects from the use.
The release form of the drug "Clarithromycin" is 500 mg, 250 mg in tablet form. 10 tablets are available in a plastic container or plastic pack.
For which microorganisms is Clarithromycin active?
- intracellular: Chlamydia pneumoniae, Legionella pneumophila, Mycoplasma pneumoniae, Chlamydia trachomatis, Ureplasm urealyticum;
- gram-positive bacteria: Streptococcus spp. (including Streptococcus pneumoniae and pyogenes), Staphylococcus spp, Corynebacterium spp, Listeria monocytogenes;
- Gram-negative bacteria: Haemophilus influenzae and parainfluenzae, Moraxella catarrhalis, as well as Vordetella pertussis, Neisseria meningitidis, Haemophilus ducreyi, Borrelia burgdorferi, Campylobacter spp., Helicobacter pylori;
- anaerobes: Bacteroides melaninogenicus, Peptococcus spp., as well as Clostridium perfringens, Eubacterium spp. Propionibacterium spp;
The drug "Clarithromycin", its analogues. Indications for use
- Respiratory system diseases: laryngitis, sinusitis, tonsillitis, tracheitis, pharyngitis, bronchitis, bacterial pneumonia.
- Diseases of the skin and soft tissues: wound infection, impetigo, furunculosis, folliculitis.
- Digestive system diseases: gastric and duodenal ulcer.
The drug "Clarithromycin", its analogues. Contraindications
Hypersensitivity to the active substance; simultaneous administration of the drugs "Cisapride", "Pimozide", "Terfenadine" and "Astemizole"; porphyrin disease. The drug "Clarithromycin" and its analogues should be used with caution in the treatment of elderly people and children up to six months (since the safety of the use of the medication has not been established), as well as if the patient has renal or hepatic insufficiency.
During pregnancy, the drug "Clarithromycin" can be used in the absence of an alternative only if the expected benefit will exceed the risk of undesirable effects in the unborn child. Studies that would confirm the safety of the use of this antibiotic during the gestation period have not been conducted. With lactation during treatment, it is necessary to stop breastfeeding.
Side effects of the drug "Clarithromycin" and its analogues
Possible side effects from the following systems:
- nervous: headache, anxiety, dizziness, fear, insomnia, tinnitus, nightmares, changes in taste sensations: less often - hallucinations, disorientation, psychosis, confusion, hearing loss after discontinuation of the drug, paresthesia;
- digestive: a feeling of nausea, vomiting, discomfort in the abdomen, diarrhea; glossitis, stomatitis, cholestatic jaundice: less often - pseudomembranous enterocolitis, hepatitis, liver failure;
- cardiac and vascular: thrombocytopenia, leukopenia; rarely - an increase in the QT interval, ventricular arrhythmia, paroxysmal ventricular tachycardia, ventricular fibrillation;
- Genitourinary: renal failure , interstitial nephritis .
It is also possible the development of allergic reactions: skin rash, itching, malignant erythema, exudative, anaphylactic shock. In rare cases, the resistance of microorganisms to the drug "Clarithromycin" and its analogues develops.
The drug "Clarithromycin" - analogues.
Each analogue contains the same active substance - clarithromycin.
Excipients can be: magnesium stearate, starch, purified talc, aerosil, microcrystalline cellulose, polyvinylpyrrolidone, sodium starch glycolate, hydroxypropyl methyl cellulose, titanium dioxide, various dyes.
To date, there are the following analogues of the drug “Clarithromycin” - these are the medicines “Klabaks”, “Klatsid”, “Clerimed”, “Clarithromycin Verte”, “Arvitsin Retard”, “Criksan”, “Binoklar”, “Claritsit”, “Klarbakt” , "Klasin", "Fromilid", "Klareksid", "Klaritrosin", "Klatsid SR", "Ekozitrin", "Clarithromycin-Protekh", "Seidon-Sanovel", "Arvitsin".
When choosing an analogue, you should consult your doctor. When buying a patient, a too low price and an unknown manufacturer should be alerted.