How effective is Pyrogenal? Reviews about this tool are reviewed at the very end of the article. In addition, the properties of this medication, its release form and methods of application will be presented to your attention.
Form, description of the drug, composition
The drug in question comes on sale in the following forms:
- "Pyrogenal" - injections. Reviews of experts report that such a tool is available in the form of a colorless and transparent intramuscular solution in ampoules of one milliliter. Its main substance is lipopolysacchard, which was isolated from bacteria Salmonella typhi. Also in the composition of this medicinal fluid is a phosphate-buffered saline solution with a pH of 6.7-7.3.
- "Pyrogenal" - rectal suppositories. Reviews of pharmacists indicate that such suppositories have a yellowish-white color, as well as a cylindrical shape, pointed at one end. The active component of this agent is a bacterial type lipopolysaccharide and such auxiliary elements as lanolin, purified water and cocoa butter.
Pharmacology of the drug
What is the medicine "Pyrogenal"? The reviews of experts claim that this is a non-specific highly active immunomodulator that can cause a whole complex of complex physiological and immunological changes in the patient’s body, as well as activate the fibrinolytic, hypothalamic-pituitary and reticuloendothelial systems.
The drug in question exhibits desensitizing, anti-inflammatory and adjuvant properties, and also increases the specific and general resistance of the human body and affects the thermoregulation centers of the hypothalamus.
Features of the medication
What is remarkable for such a tool as Pyrogenal? According to doctors, this medicine is able to activate macrophages, enhance phagocytosis, stimulate the production of interleukin-1, which causes the proliferation of body cells, interleukin-2, necessary to support lymphocyte growth, induction of interferon (endogenous), tumor necrosis factor and active forms of O2. It should be noted that an increase in the activity of phagocytes accelerates the formation of antibodies and contributes to the growth of antimicrobial resistance of the human body.
Thus, due to the activation of monocyte-macrophage cells and the cytokines secreted by them, the working activity of the humoral and cellular immune response is noticeably enhanced.
Under the influence of the Pyrogenal preparation, the development of fibroblasts and the formation of collagen fibers in the connective tissue are suppressed, which ultimately leads to a rejuvenation of the composition of cells and a slowdown of glial scarring.
It should also be noted that the use of the agent in question is able to prevent the formation of new and resorption of previously formed dense scars and adhesions at the sites of damage, as well as to prevent obliteration of blood vessels and stimulate epithelization and tissue regeneration.
Drug properties
What features are characteristic of such a medication as Pyrogenal? Reviews indicate that this tool not only stimulates the activity of hyaluronidase and the kinin system well, but also improves the fibrinolytic properties of blood, as well as increases the active activity of lysosomal enzymes and tissue permeability, accelerates the penetration of drug elements into the lesion, eliminates the inflammatory process and restores circulation.
It should also be said that the use of "Pyrogenal" helps to activate the pituitary system, increase the concentration of hormones in the blood, anti-inflammatory and analgesic effect.
Indications for use
What is prescribed Pyrogenal medication from? The use (reviews of this tool are presented below) of the drug in question is indicated for non-specific therapy:
- with traumatic injuries of the peripheral and central NS, cerebral arachnoiditis and spinal hernias;
- in surgery for adhesive disease, post-burn keloid scars and contractures, injuries, vascular diseases, as well as to prevent vascular obliteration;
- with infertility and inflammation of the uterus;
- with chronic liver diseases;
- with adhesive diseases of the abdominal cavity;
- with torpid current form of tuberculosis at the stage of resorption;
- with severe burns of the visual organs, iridocyclitis, uveitis, clouding of the cornea, herpesvirus infection of the eyes, neuralgia of the auditory and optic nerve, conjunctivitis and viral keratitis;
- with strictures of the ureters and urethra, as well as chronic urethritis and prostatitis;
- with sexually transmitted diseases, psoriasis and other skin ailments of a chronic nature;
- with the resistance of microorganisms to antibiotic and chemotherapy.
It should also be noted that as a pyrogenic drug, the drug in question is actively used for indications for pyrotherapy, including dermatovenerology, narcology and psychiatry.
Bans to use
In what cases can not be used the drug "Pyrogenal"? Reviews indicate the following contraindications to the use of the drug:
- chronic diseases in the stage of decompensation and exacerbation, except those that are indications for the appointment of a medication;
- blood diseases;
- febrile illness (acute);
- lactation and pregnancy.
Patients suffering from kidney diseases, chronic ailments of the cardiovascular system and diabetes should be treated with Pyrogenal only under the supervision of a doctor.
In the presence of febrile seizures and convulsive readiness, the medication in question is either not used or is administered together with anticonvulsant therapy.
The drug "Pyrogenal": instructions for use
Reviews of doctors report that intramuscular injections of this medication should be carried out every other day at 1 injection per day.
To prepare a medicinal solution, the contents of the ampoule must be mixed with sodium chloride.
The course of treatment with this agent begins with a dosage of 2.5 mgk, after which it is gradually increased (every day) by 5 mgk. The maximum permissible single dose of Pyrogenal is 100 mgk.
The course of treatment with the drug in question is usually limited to 15-30 injections. Repeated injections can be carried out only after two months.
How should I use the drug in the form of candles? According to the instructions, rectal suppositories are used one at a time (50 mgk). The highest dosage of this drug per day is 200 mgk.
Patients using this form of medication must adhere to the following treatment regimen - rectal suppositories are administered three times a day at a dosage of 50, 150, 100 or 120 mgk.
Usually, about twelve suppositories are consumed per course of therapy. Most often, such suppositories are used for immunorehabilitation and for immunopreventive treatment in the process of recovering a patient after acute bacterial and viral diseases at a dose of 100 or 50 mgk. As a rule, the course of such therapy is limited to 10 suppositories.
Combining injections and suppositories of Pyrogenal is not prohibited.
Negative effects
What side effects does medication “Pyrogenal” cause? Reviews of men and women say that when using suppositories, they often increase body temperature to 37.6-37.8 degrees, and also manifest such primary flu symptoms as chills, fatigue, fever, nausea, headaches, arthralgia and myalgia .
As for the solution for injection, when it is introduced, the patients experience the same adverse reactions, lower back pain occurs.
Interaction
"Pyrogenal" is acceptable to combine with drugs used to treat the above indications. It should be remembered that as part of complex therapy, this drug can enhance the effect of chemotherapeutic drugs.
Similar means
There are no analogues of the Pyrogenal preparation for the main active substance. As for similar drugs in pharmacological action, the following are referred to them: “Prodiogizan” and “Transfer Factor”. By the way, the last drug is considered the most effective and high-quality.
Drug Reviews
What do the experts say about the Pyrogenal preparation? Reviews of gynecologists and other doctors are very diverse. According to them, the provocation with the Pyrogenal medication contributes to a more rapid diagnosis, as well as the timely start of adequate treatment.
As for patients, most of them respond to this remedy exclusively from the negative side, paying particular attention to the pronounced soreness of the injections.
It should also be noted that many are simply not ready for such side effects as fever and malaise, which appear at the very beginning of therapy. Although the therapeutic effect of this drug in patient reviews is not criticized.