"Elikvis" - a drug manufactured in the USA, is a selective inhibitor of factor Xa blood coagulation. Due to the relatively high price, people often have to look for an analogue. Elikvis has several of them.
"Elikvis" - instructions for use
The active substance in the composition of the drug is apixaban. Available in the form of tablets of 2.5 and 5 mg, 20 or 60 pieces per pack. The mechanism of its action on the body is to slow down the activity of the coagulation factor. Indicated for the prevention of venous thromboembolism after prosthetics of the knee or hip joints. The drug is used under the strict supervision of a specialist, as there is a risk of bleeding. This is especially true for patients with bleeding disorders, gastrointestinal ulcers, arterial hypertension, bacterial endocarditis, hemorrhagic stroke.
Also at risk are those who have undergone surgery on the brain or spinal cord, ophthalmic surgery. Contraindications: allergic reactions, diseases of the liver, kidneys, pregnancy, lactation, age under 18 years, diseases associated with impaired blood coagulation and the risk of bleeding. Patients note its high efficiency in the postoperative period. But the high price (about 2500 rubles for a large package of 60 tablets) makes us choose cheaper analogues instead of Elikvis.
Xarelto. Description
"Xarelto" made in Germany is the most popular analogue ("Elikvis" has another active substance). The drug is a direct-acting anticoagulant. Available in the form of tablets of 5 and 10 pieces. The active component is rivaroxaban, which is a direct inhibitor of blood coagulation factor Xa, has a high bioavailability when used internally. During treatment, constant monitoring of the level of blood coagulation is not needed.
The drug is rapidly absorbed, the maximum concentration is observed 2-4 hours after ingestion, regardless of the meal. It is excreted in urine and feces. It is used to prevent venous thromboembolism after surgery on the lower extremities.
Contraindications and side effects
A lot of contraindications have an analogue (Elikvis is also rich in them). These include:
• hypersensitivity to the components of the drug, lactose intolerance;
• active bleeding (intracranial, gastrointestinal);
• disorders associated with the risk of bleeding (gastric ulcer, cancer, brain or spinal cord injury, cerebral hemorrhage and others);
• simultaneous use of other anticoagulants;
• liver diseases, accompanied by a risk of bleeding (cirrhosis B and C classes);
• pregnancy, lactation;
• age less than 18 years.
It is not recommended for severe renal failure. Just like the Elikvis medicine, the analogue has a large list of possible negative consequences.
Side effects appear in the form of disruptions:
- hematopoietic systems (anemia, thrombocythemia);
- cardiovascular system (hypotension, tachycardia);
- organs of vision (eye hemorrhage);
- digestive system (gastrointestinal bleeding, gums, rectal; pain, nausea, constipation, diarrhea, vomiting);
- liver (jaundice);
- nervous system (dizziness, headache, rarely - fainting);
- genitourinary system (bleeding);
- respiratory system (nosebleed);
- the immune system (allergic reactions);
- skin tissue (itching, rash).
During treatment with the drug, pain in the extremities, fever, deterioration of the general condition of the body are possible.
Warfarin
“Warfarin” is another analogue (“Elikvis”, in contrast to it, is an anticoagulant of direct action). The warfarin Nycomed produced in Denmark is popular. Also in pharmacies you can find the Latvian "Warfarex", the Finnish "Marevan", the Russian "Warfarin". Compared with other substitutes for the drug "Elikvis", domestic analogues are most acceptable in price.
The active substance warfamine is an indirect anticoagulant derived from coumarin. It is rapidly excreted from the body through the gastrointestinal tract and skin. Indicated for use in the treatment and prevention of blood vessel embolism , postoperative thrombosis, repeated myocardial infarction, with prosthetic heart valves. It is used in the treatment of thrombosis (surgical or medication) as an additional therapy.
Contraindications warfamine
Due to the large number of side effects, instructions for use should be carefully studied before taking "Elikvis". Analogs in this do not lag behind and have the following contraindications:
- blood pathology, its change;
- diseases with a risk of bleeding;
- recent brain, eye surgery;
- gastrointestinal ulcer;
- diseases of the respiratory system;
- aneurysms;
- DIC;
- severe liver and kidney disease;
- diseases of the genitourinary system;
- arterial hypertension;
- pregnancy.
Whether it is safe to use by persons under the age of 18 is not established.
Possible side effects:
- bleeding, anemia, skin necrosis;
- dermatitis, skin rash, itching, swelling;
- nausea, abdominal pain, vomiting, hepatitis, diarrhea;
- chills, vasculitis;
- headache, dizziness, tiredness, taste disturbance.
Pradaxa
Pradaxa is an analogue produced in Germany (Elikvis differs in composition). It is a direct thrombin inhibitor. The active ingredient is dabigatran etexilate mesylate. Available in capsule form of 10 and 60 pieces per pack. When taken quickly absorbed in the stomach. "Pradax" is used for the prevention of:
- venous thromboembolism after surgery on the lower extremities;
- stroke and systemic thromboembolism;
- recurrent thrombosis;
- pulmonary embolism.
It is also a treatment for acute thrombosis. Pradaxa reduces mortality due to these diseases.
Contraindications to the use of "Pradaks"
The presence of many side effects speak about the drug "Elikvis" reviews. Analogs also have their contraindications and possible negative consequences. Contraindications include:
- hypersensitivity to the active or auxiliary components of the drug;
- renal failure (severe form);
- active bleeding, impaired hemostasis, hemorrhagic diathesis ;
- organ damage due to bleeding;
- gastrointestinal ulcer;
- malignant tumors;
- injuries to the brain, spinal cord, recent operations;
- transferred intracranial hemorrhage;
- liver disease, impaired function;
- vascular aneurysms;
- taking other anticoagulants.
There is no information on the effect of the drug on patients under the age of 18. Use the drug with caution in case of impaired renal function, patient weight less than 50 kg, persons over 75 years old and in the presence of diseases with the risk of bleeding.
Side effects, the appearance of which is possible when taken, are similar to previous drugs:
- bleeding
- skin inflammations;
- disorders of the nervous, digestive, respiratory, genitourinary systems;
- chills, fever, headaches and muscle aches and others.
Compare prices
As has already become apparent, in pharmacies you can buy substitutes for the drug "Elikvis". Analogs are cheaper, but no less high-quality, they are produced in different countries, with different composition from each other. Therefore, their prices are different. So, the average cost of "Xarelto" is in the range of 1,500 rubles. Buying Pradaxa will cost 700-800 rubles. The most budgetary option is warfamine-based drugs. They are produced by pharmaceutical companies in several countries. "Warfarin Nycomed" Danish production - about 150 rubles. The price of the Finnish "Marevana" is in the same range. Unlike the expensive Elikvis drug, analogues are cheaper, but not inferior in quality. Confirmation of this is the numerous cases of successful completion of the postoperative period. The most economical analogues of domestic production, such as Warfarin, its acquisition will cost about 70 rubles.