Very often, the cause of unpleasant odor and itching is a fungus. This is a medical and aesthetic problem that brings considerable discomfort. You have to constantly walk in closed shoes and keep your distance from family and friends. Fungal diseases can be quickly cured with the help of special medications. Good results are shown by Dermazole (ointment). But to use the medicine is strictly according to the instructions and only after consulting a doctor.
The composition of the medication
"Dermazole" is an antifungal agent for external use. The main active ingredient is ketoconazole. As excipients, propylene glycol, stearyl alcohol, sorbitan stearate, polysorbate, isopropyl myristate, anhydrous sodium sulfate, and also purified water are used. The medicine goes on sale in aluminum tubes and special cardboard packaging. In order for the ointment to retain its useful properties longer, it should be kept in the refrigerator.
Dermazole ointment has a fungistatic effect on the skin. The mechanism is to change the lipid composition of the membrane of pathogens. They cease to multiply and soon die. The medication is active against microorganisms that contribute to the development of
multi-colored lichen, as well as some dermatomycoses. In addition, the main active ingredient can act against gram-positive cocci.
Pharmacokinetics
Ketoconazole is a fairly weak compound that dissolves quickly in an acidic environment. The maximum content of the active substance in the plasma is achieved only a few hours after the application of the drug "Dermazole". Ointment has a cumulative effect. You can’t notice the improvements from the first use. The maximum bioavailability of the drug is achieved when it is taken with food in the form of tablets. In patients who have an increased acidity of the stomach, the absorption of ketoconazole is reduced. Therefore, it can be difficult to correctly determine the dosage of a drug.
The main component binds in the liver after absorption in the gastrointestinal tract. In this case, many inactive metabolites can form. The main metabolic pathways are the cleavage of the piperazine ring. Only 15 percent of the drug is excreted in the patient's urine. No more than 5 percent comes out unchanged. More than 60 percent of ketoconazole is excreted from the body along with feces.
Indications
It can be used in various cases "Dermazole" (ointment). Instructions for use states that the medicine can be used externally for many diseases. Most often it is used to treat various candidiasis. Often helps to cope with the neglected form of the foot fungus ointment "Dermazole". What else will the drug save? The ointment is prescribed for the treatment of inguinal epidermophytosis, epidermophytosis of the hands and feet, pityriasis versicolor, seborrhea.
With topical application, acute vaginal candidiasis or a chronic recurrent form of this disease can be cured. Also, the medication is used for preventive measures. The ointment is applied to the genitals to avoid the re-development of a fungal infection. It is necessary to protect yourself with a reduced resistance of the body or after a course of treatment with antibacterial agents. It is worth remembering that antibiotics kill not only pathogens, but also beneficial ones. And as a result, microflora suffers.
Dermazole ointment may not give the desired effect when applied topically. Then the medication is prescribed orally in the form of tablets. The drug is used for diseases such as histoplasmosis, blastomycosis, paracoccidioidomycosis, as well as coccidioidomycosis.
Contraindications
The medication can not be used with individual intolerance to its components. It is necessary to take Dermazole (ointment) with caution in patients who have chronic liver disease. The decision to use the drug should be made by the doctor. The medication in tablet form cannot be prescribed for children under three years of age, as well as for pregnant and lactating women. Ointment "Dermazole" during pregnancy and lactation is allowed.
The drug in the form of tablets is incompatible with many drugs. Using it without first consulting a doctor can lead to serious side effects. Be sure to consult a dermatologist for people who suffer from chronic diseases and are forced to constantly take medications. In rare cases, unpleasant symptoms begin to appear even when using multivitamins in conjunction with Dermazole. Allergic reactions associated with hypersensitivity may occur.
special instructions
It can not be prescribed for fungal meningitis ointment "Dermazole". The use is impractical, since the main active component does not penetrate the blood-brain barrier. Some patients have a high risk of hepatotoxicity. Therefore, the specialist must conduct a number of necessary tests, weigh the pros and cons. The drug is prescribed only when the benefit exceeds the potential risk to the patient.
People with increased activity of liver enzymes that arose during treatment with other medicines should not take Dermazole (ointment). Reviews show that the positive effect under such conditions is almost imperceptible. In this case, the patient can cause even greater harm to his body. For people with severe liver failure, an
antifungal ointment is generally contraindicated. Before prescribing a medicine, a specialist must study
the liver function of the patient. To do this, a number of analyzes are carried out. If the drug is still prescribed, it is necessary to constantly monitor the picture of peripheral blood. This allows you to notice the first symptoms of hepatotoxicity in a timely manner and cancel the Dermazole ointment. You can always choose a more gentle drug.
If glucocorticosteroids were prescribed for the treatment of skin diseases , then an antifungal ointment can be prescribed no earlier than two weeks after their cancellation.
Dosage
It can be prescribed only to people who have undergone a complete examination of Dermazole ointment from a fungus. Reviews of doctors indicate that such a drug can be harmful to children. Therefore, it should be used strictly according to the instructions. The medicine is intended for external (ointment) and internal use (tablets). Ingestion is carried out in a dosage of 200-400 mg per day. For children weighing less than 30 kg, the dosage is calculated individually and is 5-10 mg per 1 kg of weight.
External use may depend on the form and extent of the disease. To treat a foot fungus or hairline, the medicine is applied several times a day to the affected area. You can also do compresses at night for feet. "Dermazole" (ointment) is applied to the nail plate and feet and put on a gauze bandage. Fungal diseases are treated at home. A dermatologist should be visited periodically to control the course of the disease.
Side effects
People with chronic diseases should use Dermazole (ointment) with caution. The instruction describes a number of side effects in which you should stop taking the drug. On the part of the nervous system, untidy symptoms such as migraine, dizziness, fatigue, weakness, drowsiness in the daytime, and insomnia at night can be observed. In most cases, such phenomena are observed when using Dermazole tablets. Sometimes patients may experience an increase in intracranial pressure. First of all, the optic nerve discs swell . Such side effects are reversible and do not require drug withdrawal.
For external use, Dermazole ointment can cause irritation, redness of the skin.
You should immediately stop taking the medicine if symptoms such as vomiting, impaired liver function are observed. All this can lead to severe hepatotoxicity. The patient may develop cirrhosis or liver failure. Such changes are irreversible.
In some cases, patients may experience a failure in metabolism. Patients begin to quickly gain weight or, conversely, refuse meals. As a result, anorexia develops, which requires additional treatment.
People who are prone to allergic reactions should also use Dermazole (ointment) with caution. Instructions for use describe the first symptoms of intolerance to the drug. This is a skin rash and itching. In rare cases, allergies manifest as swelling of the limbs and face. If such symptoms appear, you should immediately stop taking the drug.
At the initial stage of treatment, patients may also experience chills or fever. Unpleasant symptoms do not indicate changes in the body and do not require withdrawal. A few days after the start of therapy, patients feel normal.
Drug interaction
Do not take antifungal drugs in the form of tablets based on ketoconazole in conjunction with antacid drugs. Aluminum hydroxide, as well as proton pump inhibitors, reduce the absorption of the main active substance from the gastrointestinal tract. The antifungal activity of Dermazole may be significantly reduced. If the interaction of drugs cannot be avoided, the dosage must be adjusted.
Significantly reduce the bioavailability of ketoconazole such substances as rifabutin, carbamazepine, rifampicin, efavirenz, nevirapine. When taken with drugs based on these components, Dermazole may be ineffective. Similar drugs should also be used with caution. Only a doctor can choose a good substitute.
The development of side effects can provoke the combined use of ketoconazole with substances such as tamsulosin, rifabutin, carbamazepine, salmeterol, nilotinib. If such combinations cannot be avoided, it is worth constantly monitoring the patient's condition. Ideally, his treatment should take place in a hospital setting.
Dermazole ointment is well combined with other drugs.
Analogs
What to do if for a number of reasons it was not possible to purchase Dermazole (ointment)? Analogs can always be found by a doctor. The drug Nizoral, which also works on the basis of ketoconazole, is popular among specialists. The medicine is available in the form of a cream and goes on sale in aluminum tubes. Nizoral cream is prescribed for skin diseases such as pityriasis versicolor, candidiasis, seborrheic dermatitis, dermatomycosis, and inguinal epidermophytosis. The medicine has practically no contraindications. It is canceled, as in the case of Dermazole, only if the patient develops hypersensitivity to any of the components of the drug. Ointment "Nizoral" is allowed for use during pregnancy and lactation. But treatment should begin only after consulting a doctor.
Mikospor Cream is another popular antifungal drug. The main active ingredient is bifonazole. As auxiliary substances, cetostearyl alcohol, polysorbate, sorbitan stearate, cetyl palmitate, and also purified water are used. The medicine is prescribed for foot mycoses, erythrasma, superficial candidiasis of the skin. Contraindications also include only hypersensitivity to one of the components of the drug.
Thus, all these medicines are no worse than Dermazole ointment. Similar drugs do their job well.
Reviews about the drug "Dermazole"
Patients who use the drug strictly according to the instructions respond well to the drug “Dermazole”. Patients say that the medication really copes with candidiasis, mycoses. There is also "Dermazole" in the form of shampoo. Reviews indicate that this is an excellent remedy for seborrhea of the scalp (dandruff). Of course, the tool is not cheap, but it really helps.
The medication has a cumulative effect. Therefore, changes cannot be seen from the first application. A good result begins to appear on average after a week of therapy. Doctors say that a medicine based on ketoconazole acts much better on the body if the patient does not conduct treatment with other medicines at the same time. When prescribing Dermazole tablets and ointments, each specialist clarifies the patient’s presence of chronic diseases and the need to take any medications.
The drug has many side effects. Therefore, it is worth using caution "Dermazole" (ointment). Instructions, reviews - all this is worth exploring before starting treatment, before purchasing the drug in a pharmacy. The doctor will be able to provide all the necessary information.
The drug is dispensed without a prescription. You can find it in almost any pharmacy. Dermazole ointment belongs to the middle price category. For one tube you have to pay about 150 rubles. You can save significantly if you order the medicine online. In online pharmacies, prices are often 15-20% lower.
The patients' reviews show that Dermazole ointment is even more effective if it is used together with alternative methods. Against fungal diseases of the foot, a decoction of celandine perfectly helps. A little fresh grass is poured with hot water and insisted for 20-30 minutes. Celandine perfectly fights with fungal infections of varying severity. Broth can wipe the affected areas several times a day. Do not forget also about the correct medication. The ointment "Dermazole" will help to completely forget about the fungus.