What is the medication "Adenorm" prescribed for? Instructions for use of the drug and its indications are listed below. Also, this article provides information on the form in which this product goes on sale, what patients say about it, and with what analogue it can be replaced.
The composition of the drug, its description and form
In what form is a product such as Adenorm produced? Instructions for use states that this drug can be purchased in the form of solid white-yellow capsules. The active component of this medication is tamsulosin hydrochloride. As additional constituents, spherical sugar, hydroxypropyl methyl cellulose, ethyl cellulose, hypromellose phthalate, povidone, diethyl phthalate, talc and cetyl alcohol are used.
As for the hard gelatin capsule, it consists of the dye indigotine, iron oxide yellow, iron oxide red, gelatin and titanium dioxide.
Pharmacological features
In what cases use the drug "Adenorm"? Instructions for use states that this tool is often prescribed for prostatic hyperplasia (benign type).
The medication under consideration refers to antagonists of alpha1-adrenergic receptors located in the smooth muscles of the gland of the prostate, prostatic part of the urethra, as well as in the body and neck of the bladder. Thanks to the effect of this tool, their tone is reduced.
We can not say that this drug improves the detrusor, helps to eliminate the symptoms of irritation and obstruction, which are manifested due to prostatic hyperplasia.
How fast does the drug "Adenorm"? Instructions for use report that the effectiveness of this medication is noticeable two weeks after the start of treatment. In this case, a decrease in the manifestations of the disease can be noticed in the first days of the course.
Pharmacokinetic properties
For the drug "Adenorm", reviews of which are only positive, linear kinetics is characteristic. Its active substance is rapidly absorbed from the intestine. The highest plasma concentration of the drug after taking a single dose of 0.4 mg is observed after 6 hours. In this case, a fairly strong bond with proteins arises.
According to the instructions, this medication breaks down very slowly in the liver (inactive derivatives are formed). The main part of the active element is present in the human body unchanged.
With a single dose of the drug in a dosage of 0.4 mg, the half-life is 10 hours, and with prolonged use - about 12 hours.
The drug is excreted from the body through the kidneys in the form of derivatives (about 9% of the drug is excreted unchanged).
Indications for taking capsules
The drug Adenorm, the analogues of which are listed below, is used in the treatment of urinary tract disorders (lower), including in the presence of prostatic hyperplasia (benign type).
Contraindications to taking gelatin capsules
In what cases is it forbidden to prescribe Adenorm medication? Instructions for use, reviews claim that this tool can not be used with hypersensitivity to its ingredients, as well as in the treatment of patients with impaired liver function (of a severe nature).
In addition, the drug in question is not prescribed for people with a history of orthostatic hypotension .
This medicine should be used with extreme caution to those who suffer from impaired renal function (including with CC less than 10 ml / min). In addition, Adenorm capsules are not recommended for patients whose activity is related to driving or potentially dangerous mechanisms. Otherwise, work should be abandoned.
Medication "Adenorm": instructions for use
The agent in question is taken orally. The hard capsule should be swallowed in its entirety, without crushing and chewing, with plenty of water.
The medicine is used regardless of the meal. The duration of the course of treatment, as well as the dosage of the drug, is determined by the attending physician, individually for each patient.
As a rule, for adults, the medicine "Adenorm" is prescribed one capsule once a day.
For people with minor impaired liver or kidney function, dose adjustment is not required. As for patients with severe problems in this area, the advisability of taking and dosage of this drug is determined by the attending physician taking into account the overall clinical picture.
Side effects
When taking the drug in question, the following negative consequences are possible:
- the development of rhinitis;
- headaches, dizziness;
- rash on the skin, itching and urticaria;
- orthostatic hypotension, palpitations;
- asthenia.
In rare cases, patients experience: fainting, Stevens-Johnson syndrome, constipation, angioedema, nausea, retrograde ejaculation, diarrhea, priapism, and vomiting.
It should also be noted that there are cases of intraoperative instability of the iris of the visual organs during surgical intervention for cataracts in people who have been taking medications with tamsulosin as an active substance for a long time.
Overdose cases
Now you know the features of such a medicine as Adenorm. A description of the drug has also been presented above.
With an overdose of this drug in patients, blood pressure can drop sharply. In this case, maintenance therapy should be carried out in order to normalize the work of CVS. Also, infusion treatment is sometimes carried out and vasopressor drugs are prescribed.
When taking the drug, it is imperative to monitor the work of the kidneys, and if necessary, conduct general supportive therapy.
In case of excessive overdose with this tool, you should induce vomiting, rinse the stomach and prescribe laxatives and activated charcoal to the patient.
Interaction with other medicines
Joint administration of the medication in question with other alpha-1-blockers enhances its hypotensive effect.
When capsules are combined with Cimetidine, the concentration of the active substance Adenorm increases, while with Furosemide it decreases. Although at the same time its level almost always remains within the normal range, therefore, the dose should not be adjusted in such cases.
NSAIDs such as Warfarin and Diclofenac can increase the rate of elimination of Adenorm from the patient’s body.
Together with strong inhibitors of CYP3A4 and CYP2D6, increased doses of the drug in question are unacceptable or are taken with extreme caution.
Cost and analogues
The price of Adenorm medicine is about 360-400 rubles. If required, then this drug is replaced with such agents as Hyperprost, Tamsulosin or Omnic.
Reviews
As a rule, the drug in question is prescribed by urologists after the patient undergoes an ultrasound of the prostate and blood donation for PSA. Acceptance of this drug is allowed only if the patient has the appropriate indications.
Consumers claim that the drug Adenorm copes well with its task. Although some of them complain that it causes side effects such as persistent headaches and a feeling of palpitations.