Migraine is the ailment that can not be transferred without taking analgesics. The attack can last up to 4 days. A person in such a period loses his ability to work. At the same time, he uses potent drugs to get rid of throbbing pain. But, unfortunately, most of the means that can eliminate such discomfort cause dependence and lead to the fact that the disease takes on a chronic form. Modern pharmacology has developed a great new drug. Exedrine is a remedy that perfectly relieves migraines, restores disability, but does not cause dependence, at the same time. Analogues of the drug are no less effective.
a brief description of
The migraine medicine Exedrine is a combination drug that belongs to the group of analgesics-antipyretics. It is used for severe headaches. Effectively means "Excedrine" for migraine. However, it can even prevent an attack.
The composition of the drug
The effectiveness of the drug lies in its components. The medicine contains:
- acetylsalicylic acid;
- caffeine;
- paracetamol.
It is thanks to these elements that a versatile effect on the body occurs. As a result, a quick effect is guaranteed, the pain syndrome is completely stopped.
Paracetamol in an amount of 250 mg, acetylsalicylic acid - 250 mg and caffeine - 65 mg contains one tablet of the medicine "Exedrine". The composition, therefore, in this agent of active substances is very significant. That is why it is recommended to use the drug with extreme caution. Patients should strictly consider the dosage and not exceed it.
In addition, this preparation includes auxiliary ingredients:
- hyprolosis;
- microcrystalline cellulose;
- stearic acid.
Effects on the body
Exedrine Migraine Tablets are made from three different substances that have different properties. Their combination allows you to get rid of pain of any nature. Since migraine attacks are accompanied by a sufficiently long and severe discomfort, a very strong medicine is needed to get rid of it. This is exactly what Exedrine is.
What is its effect and what effect does this remedy have? The answer to the question lies in the effect on the body of each component contained in the medicine:
- Paracetamol. The substance has excellent anti-inflammatory and antipyretic properties. It can affect the brain center, which is responsible for controlling the temperature in the hypothalamus. It is the anti-inflammatory quality that plays an important role in eliminating migraines, since fever does not belong to the symptoms of the disease.
- Acetylsalicylic acid. The component is distinguished by pronounced antipyretic properties. It is able to inhibit and eliminate inflammatory processes. At the same time, it reduces pain. Acetylsalicylic acid can prevent blood clots. It stops the process of their formation at the cellular level, perfectly improves blood circulation in the inflamed areas.
- Caffeine. The role of this substance in reducing pain is most significant. Acetylsalicylic acid and paracetamol can temporarily eliminate discomfort. Caffeine has a positive effect on blood circulation in the brain and helps get rid of the causes of pathology. In addition, it excites the respiratory and vasomotor centers, promotes the expansion of narrowed blood vessels, and prevents platelet binding. Caffeine perfectly relieves fatigue and drowsiness. It significantly increases the working capacity of the body and its tone, thereby improving the overall well-being of the patient. The combination of acetylsalicylic acid with this substance can increase blood flow and positively affect the blood vessels of the brain.
Pathologies in which the drug is used
It is advisable to use Exedrine tablets for pain syndromes of mild and moderate intensity of various origins:
- migraine;
- headache;
- neuralgia;
- toothache;
- myalgia, arthralgia (discomfort in the joints and muscles);
- algodismenorea (pain during menstruation);
- febrile syndrome.
Pharmacokinetics of the drug
In most cases, Exedrine is well tolerated by the body. Customer reviews fully confirm this. The drug is obliged to such an effect by its components:
- Paracetamol is perfectly absorbed in the digestive tract. It is metabolized in the liver, and excreted by the kidneys in the form of sulfate conjugates and glucuronides. Less than 5% of the substance leaves unchanged. With plasma proteins, the relationship is negligible with the usual therapeutic dose. But with an increase in the latter, it increases. Hydroxylated metabolite, formed in small quantities in the liver under the influence of mixed oxidases and usually neutralized by binding to glutathione, can accumulate during an overdose of paracetamol and cause liver damage.
- Acetylsalicylic acid is completely and very quickly absorbed. It undergoes hydrolysis in the digestive tract, blood and liver. In this case, salicylates are formed. They are subsequently metabolized in the liver.
- Caffeine is also rapidly absorbed in its entirety. The maximum concentration in the body is observed for 5-90 minutes after using the drug on an empty stomach. Excretion occurs as a result of hepatic metabolism. The substance is distributed throughout all body fluids. Communication with plasma proteins reaches 35%. The component is completely metabolized and excreted by the kidneys.
Dosage regimen
Intended for oral administration tool Exedrine. The medicine is taken during or after a meal. It is recommended to drink plenty of water.
A single dose for adults and adolescents (from 15 years old) is 1 tablet every 4-6 hours. If a person feels signs of impending migraine, it is recommended to use 2 pills immediately. This will prevent an attack of the disease. However, it should be remembered that consuming more than 6 pieces per day is strictly prohibited.
Important Caution
An effective medicine is allowed to be used to eliminate pain discomfort for 3 days. During this time, the patient should consult with his doctor, who will choose the perfect alternative remedy to combat the pathology.
In some cases, the patient is recommended to prolong the use of the drug. But only a specialist can make such a decision on the basis of relevant evidence. It is not recommended to use Exedrine migraine tablets on your own for more than 3 days. Increasing the dose can lead to serious consequences. Such as liver damage due to the accumulation of metabolites in the body.
Side effects
The use of medication may not completely positively affect the body. Since it has a number of side effects, Exedrine. Analogues of the drug can be recommended by the attending physician if the above medicine is not suitable for the patient.
So, the following side effects are possible:
- nausea, vomiting;
- gastralgia;
- hepatotoxicity;
- erosive and ulcerative lesions of the gastrointestinal tract;
- nephrotoxicity;
- allergic reactions;
- increase in pressure;
- tachycardia;
- dizziness;
- bronchospasm;
- headache;
- visual impairment;
- decrease in platelet aggregation ;
- noise in ears;
- hemorrhagic syndrome (gum bleeding, nosebleeds, purpura);
- exudative malignant erythema (or Stevens-Johnson syndrome);
- deafness;
- epidermal toxic necrolysis (or Lyell's syndrome);
- damage to the kidneys (papillary necrosis is possible);
- development of Raynaud's syndrome in children (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, impaired liver function).
Contraindications
Unfortunately, an effective medicine is not intended for all people. After all, the tool has a number of contraindications. They must be taken into account before use. But to despair, if the medicine did not fit, it is not worth it. The attending physician will very easily replace Exedrine. Analogs will achieve an acceptable result.
The medicine is contraindicated in the following pathologies and conditions:
- hypersensitivity to ingredients;
- gastrointestinal ulcers in the acute stage;
- bronchial asthma,
- gastrointestinal bleeding;
- recurrent polyposis of the nose (paranasal sinuses);
- intolerance to NSAIDs;
- surgical interventions that accompany bleeding;
- hemorrhagic diathesis;
- arterial hypertension;
- hemophilia;
- hypoprothrombinemia;
- portal hypertension;
- glaucoma;
- severe ischemia of the heart;
- vitamin deficiency K;
- lack of glucose-6-phosphate dehydrogenase;
- renal failure;
- pregnancy;
- lactation;
- sleep disturbances;
- increased irritability;
- children's age (the drug is not used up to 15 years).
Drug overdose
The medicine "Excedrine" for migraine should be taken only in the above doses. Because abuse of the drug can lead to many unpleasant symptoms.
The following symptoms indicate an overdose of paracetamol :
- During the first day, pale skin, vomiting, nausea, abdominal pain, impaired glucose metabolism, anorexia, metabolic acidosis are observed .
- After 12-48 hours, there may be signs of impaired liver function, expressed by insufficiency with the progression of encephalopathy. With very severe overdoses, coma and death are possible. Renal failure accompanied by tubular necrosis, pancreatitis, arrhythmia can be observed.
An overdose provoked by acetylsalicylic acid gives the following symptoms:
- In mild cases - vomiting, nausea, dizziness, blurred vision, tinnitus, headache.
- In severe poisoning - shortness of breath, cyanosis, suffocation, sticky cold sweat, respiratory acidosis, respiratory paralysis.
Caffeine-related abuse results in the following symptoms:
- gastralgia;
- excitement, anxiety;
- confusion of consciousness;
- motor anxiety;
- dehydration;
- arrhythmia;
- frequent urination;
- tachycardia;
- hyperthermia;
- increased pain and tactile sensitivity;
- tremor;
- tinnitus;
- nausea, vomiting (sometimes with blood);
- epileptic seizures.
In case of an overdose of the drug, it is urgent to seek help from doctors. During the first 4 hours, it is recommended to rinse the stomach, provoke vomiting. Laxative and Activated Carbon should be used.
Analogues of the drug
Remember that any drug should be prescribed by a doctor, since each remedy has its own indications and contraindications.
And only a doctor is able to replace Excedrine with another drug. Analogues for the active component are as follows:
- "Aquacitramone."
- "Acifein."
- "Askofen."
- Coficil Plus.
- "Citramarine."
- Migrenol Extra.
- "Citramon."
- "Citrapar."
Drug cost
For all its effectiveness, the Exedrine medicine for migraines is inexpensive for consumers. The price of packaging (10 tablets) varies from 120-150 rubles. The cost of the drug from 20 pills is 210-250 rubles.
Interaction with other medicines
Patients who use the drug "Exedrine", should understand that it can enhance the effect on the body of other drugs, such as:
- Heparin
- indirect anticoagulants;
- "Reserpine";
- hypoglycemic drugs;
- steroid hormones.
Please note that the simultaneous use of Exedrine with other NSAIDs can lead to side effects. So, for example, the interaction of the drug with antigout, antihypertensive drugs, means "Furosemide" leads to lesser effectiveness of these groups of drugs.
Consumer opinion
Any drug has (not an exception and Exedrine medicine) reviews both positive and negative.
Some consumers frankly narrate that, having tried the medicine once, they no longer part with it. Many women carry an effective product in their purse. After all, you never know when a pain attack will overtake you. Such patients notice that one tablet can eliminate an unpleasant syndrome within an hour. And in the case of severe migraines, 2 pills of the Exedrine medicine eliminate the pain. Reviews indicate the excellent effectiveness of this tool.
Other consumers take a different point of view, claiming that the drug is useless. They argue that the active ingredients of the drug can be purchased separately much cheaper at the pharmacy. However, such consumers forget that the drug received its effectiveness as a result of the correct combination of all components that complement each other perfectly.