What do you know about a drug like Komfoderm? Instructions for use, price, reviews, analogues and general characteristics of this medication are known to few. Therefore, in this article, we decided to provide all the information about this medication.
Form, composition and description
The drug "Komfoderm", the instructions for use of which are described below, is made in the form of a white cream with a specific smell (it can be without it, and also have a creamy tint).
The active components of this topical agent are methylprednisolone aceponate and urea. Also, the composition of the medicinal ointment includes auxiliary ingredients, which are presented in the form of liquid paraffin, propylene glycol, polysorbate-80, carbomer interpolymer (type A), trometamol, methiparahydroxybenzoate and purified water.
Healing properties
What is the local drug Komfoderm (cream)? Instructions for use reports that it is a glucocorticosteroid and keratolytic agent at the same time. Its action is due to the characteristics of the components that make up its composition. Consider their properties in more detail.
Methylprednisolone aceponate is a synthetic non-halogenated steroid. When used externally, it is able to suppress allergic and inflammatory skin reactions, as well as reactions that are associated with increased proliferation. Such an effect leads to a significant reduction in objective signs of the inflammatory process (erythema, edema, wetness) and subjective sensations (itching, irritation, pain, etc.).
It is impossible not to say that when using this substance in the recommended dose, its systemic effect on the human body is minimal.
After prolonged and repeated use of methylprednisolone aceponate on large surfaces of the skin (40-60%), as well as when it is applied under an occlusive dressing, the adrenal glands are not disturbed in patients, including the level of cortisol.
The substance in question is able to bind to glucocorticoid intracellular receptors, causing a number of biological effects. In particular, this chemical process leads to the induction of macrocortin synthesis. Moreover, the latter inhibits the release of arachidonic acid and the formation of inflammatory mediators such as leukotrienes and prostaglandins.
What role does urea play in Comfoderm? Instructions for use states that this component has moisturizing and keratolytic effects. It binds water, as a result of which it softens the stratum corneum of the skin.
In addition to keratolytic action, urea also exhibits proteolytic activity.
Kinetics
Is Komfoderm cream absorbed? The instructions for use states that after applying this agent methylprednisolone, aceponate is hydrolyzed almost immediately in the dermis and epidermis.
The most active and main metabolite of this substance is 6alpha-methyl-prednisolone-17-propionate.
The degree of skin absorption of the drug in question depends on the condition of the human integument and the method of its use (without or with an occlusive dressing).
Percutaneous absorption of the drug in people with psoriasis and atopic dermatitis is about 2.5%, which is slightly higher than that in healthy volunteers (approximately 0.6-1.5%).
When 6alpha-methylprednisolone-17-propionate enters the systemic bloodstream, it conjugates fairly quickly with glucuronic acid, and then it is inactivated.
The metabolites of the drug in question are eliminated mainly through the kidneys, after 16 hours. The active components of this drug do not cumulate in the body. Due to the low absorption of urea with local application of the cream, the probability of its systemic effects is negligible.
Indications
What is Comfoderm (ointment) for? Instructions for use contain the following list of indications:
- microbial eczema;
- allergic dermatitis (contact);
- neurodermatitis, atopic dermatitis;
- true eczema;
- dermatitis simple contact;
- eczema is dyshidrotic.
In other words, the drug in question is prescribed for inflammatory skin diseases accompanied by impaired keratinization, as well as showing high sensitivity to treatment with topical glucocorticosteroids.
Contraindications
The drug "Komfoderm", the instructions for use of which is mandatory for reading by all patients, is prohibited for use with:
- hypersensitivity to the elements of the cream;
- tuberculosis or syphilitic processes in the field of drug administration;
- viral diseases (including with chickenpox, shingles);
- rosacea, perioral dermatitis in the area of application of the ointment;
- any manifestations for vaccination;
- at a minor age.
Medication "Komfoderm" (ointment): instructions for use
The price of the funds in question is about 480-530 rubles. The drug is applied to the affected skin in a small layer, once a day.
The duration of continuous and daily treatment with this cream should not exceed 12 weeks. It should be noted that the treatment of skin lesions of the face must be carried out for 5 days.
Side effects
What adverse reactions are able to cause the drug "Komfoderm M2"? Instructions for use report that such effects are very rare. As a rule, they appear in the form of the following local reactions: itching, erythema, burning, formation of a vesicular rash.
In the event that the medication was used for more than four weeks or on large areas of the skin, the patient may develop atrophy of the skin or telangiectasia, as well as acneform changes, striae and systemic effects that are caused by absorption of the corticosteroid.
Also, sometimes the drug in question causes hypertrichosis, folliculitis, skin depigmentation, perioral dermatitis and allergic reactions.
Customer reviews and analogues of Komfoderma
To analogues of this drug include only the cream "Advantan".
What do patients say about Comforderm ointment? According to their reviews, the medication in question is a very effective local remedy. Its use allows you to get rid of various skin diseases, including eczema, neurodermatitis and dermatitis. In some cases, this drug is used even for psoriasis.
The disadvantages of ointment "Komfoderm" include its high cost, as well as the inability to use in childhood.