The medication "Itrazol" refers to the instructions for use as synthetic antifungal drugs. The drug has a wide spectrum of action. The drug inhibits ergosterol synthesis in the membrane of fungal cells. The active substance of the drug is itraconazole. The medication is active against dermatophytes, yeast, yeast-like fungi. The absorption of the drug comes from the digestive tract quickly and almost completely. When taken immediately after a meal, bioavailability is enhanced. After three to four hours, the medicine reaches its maximum concentration. The medication is able to quickly spread in fluids and tissues, including the vaginal mucosa, is found in the secret of sweat and sebaceous glands.
In therapeutic concentrations, the product is stored in the skin for two to four weeks after the completion of a month's course. In nail keratin, the content of the drug “Itrazol” (instructions for use indicates this) is achieved a week after the start of treatment. The therapeutic level of the drug is detected within six months after the withdrawal of the drug. The drug in the liver is metabolized. Excretion occurs through the intestines and kidneys.
Capsules "Itrazol". Indications. Dosage regimen
The drug is prescribed orally after a meal. Against the background of vulvovaginal candidiasis, the recommended dosage is 200 mg twice a day for one day or 200 mg once a day once every three days. With pityriasis, two hundred milligrams is prescribed once a day. Duration of admission is a week. With dermatomycosis, a dosage of 100 mg 1 time per day. The duration of the course is fifteen days. If there are lesions on the skin of the hands in the same dose, the therapy is extended for another 15 days. With fungal keratitis, 200 mg is prescribed once a day. The duration of taking Itrazol (the instructions for use indicate this) is 21 days. With onychomycosis, a medication is recommended for three months. Dosage - 200 mg once a day. The drug is taken continuously, daily. To eliminate lesions on the nails of the legs, regardless of the presence of damage on the nail plates of the hands, three courses are prescribed lasting one week. The interval between courses is three weeks. With lesions of the nail plates of the hands, two weekly courses are conducted with an interval of three weeks.
The drug "Itrazole". Instructions for use Contraindications
It is not allowed to prescribe medication to patients with intolerance to the components, pregnant women, children under three years of age, lactating women. The combined use of the drug with drugs such as Midazolam, Triazolam, Lovastatin, Simvastatin, Pimozide, Quinidine, Dofetilide and others is not recommended. Caution during treatment is observed with severe heart failure, pathologies in the liver, complicated by insufficiency of functions. Therapy of children should be supervised by a specialist. Assignment to patients from three to twelve years of age is carried out after assessing the ratio of expected effectiveness and the likely risk of taking the medication.
The drug "Itrazol". Instruction Price
The cost of the drug is from 345 rubles.