Instructions for use, reviews, price, analogues of "Panangin" - such information interests a person to whom the doctor recommended taking this medication. Potassium and magnesium asparaginate, produced under the trade name "Panangin", is indicated for a wide range of pathological conditions, and is also actively used by athletes to maintain the body in shape. Consider how this composition works, what are its features, what are the contraindications and indications.
"Panangin": solution
Two forms of release are on sale: a solution for infusion infusion and tablets for oral use. First, consider the features of the solution.
The instructions for use of Panangin accompanying the preparation indicate that each ampoule contains 103.3 mg of potassium ions in the form of potassium asparaginate, as well as 33.7 mg of magnesium ions in the form of magnesium asparaginate. Additionally, the manufacturer includes purified water.
The drug should be transparent, have no color or have a greenish tint. With visually noticeable deviations from the norm, the tool can not be used.
Option for oral administration
In the instructions for the use of Panangin tablets, the manufacturer indicates the presence of 158 mg of potassium asparaginate in each instance and 140 mg of magnesium asparaginate. Additionally, auxiliary components were used to ensure the duration of storage and simplify the administration of the drug. The manufacturer used starch and talc, cellulose and povidone. A complete list of used auxiliary components is given in the documentation accompanying the tablet. Carefully familiarizing yourself with it is especially important if the patient has an allergic reaction or intolerance to any compound used in the pharmaceutical industry.
The described release option is not the only one intended for oral administration. On sale there is also a Panangin Forte, which is distinguished by positive reviews of cardiologists. The instructions for use of the drug indicate that the number of active compounds in each dose is doubled compared to the standard version of Panangina. However, doctors note that this format of the product is not suitable for every patient, since it has a fairly strong effect on the balance of electrolytes in the body, and therefore, the work of the cardiac system.
It works?
Why are the reviews of cardiologists positive about the effect of the drug? In the instructions for use of Panangin, the manufacturer similarly explains why the product is effective and shows a pronounced effect when used correctly: along with the medicinal composition, potassium and magnesium ions enter the human body, that is, electrolytes that are indispensable for the life of the body, the work of many internal systems.
The effectiveness of the drug in question is also confirmed by the responses shared by the tablets that have taken the course of the introduction of the face solution. In reviews of "Panangin", analogues (instructions for use indicate that the active components are magnesium, potassium asparaginate), many mention that the drug was prescribed as an element of maintenance therapy and helped stabilize the work of the heart. Positive feedback on the effectiveness of the composition and from the athletes who used the “Panangin” under the supervision of a coach. But unauthorized use can cause side effects and unpleasant impressions, as warned by reviews of cardiologists, and instructions for the use of “Panangin” (the price of the drug is from one hundred rubles per pack).
Why does it work?
The researchers found that potassium ions are responsible for preserving the potential of the membranes of neurons, myocytes, and some elements of the heart muscle. If the potassium content inside and outside the cell is balanced, the cardiac system works fine. If this balance is disturbed, the ability of the muscle to contract decreases, rhythm and heart rate failures occur, and cardiac glycosides become more toxic.
In the instructions for use of "Panangin" (tablets, solution), the manufacturer also indicates the importance of magnesium for the human body. This electrolyte is a cofactor for several hundred reactions involving enzymes. They also include metabolism, energy, production of essential acids, protein structures. Magnesium is necessary for cardiac functioning, as it increases the contractility of the heart and stabilizes the rhythm of the process, reduces the need for cells in oxygen. A decrease in myocytic contractility leads to vasodilation, activation of coronary blood flow. Magnesium ions are an important tool for preventing ischemia of cardiac muscle tissue.
Performance Nuances
The manufacturer tells about the reasons for the positive effect of the drug on humans (and, as a result, reviews) in the instructions for use of Panangin (tablets and solution), explaining the effectiveness by the combination of electrolytes. The simultaneous ingestion of magnesium and potassium structures into the body with the drug is justified, as long-term tests have proved. It was revealed that a lack of magnesium in the predominant percentage of cases is accompanied by a lack of potassium, which means that it is necessary to adjust the content of both electrolytes in organic tissues.
Instructions for use, reviews by cardiologists about “Panangin Fort” and “Panangin” mention that the simultaneous intake of electrolytes in the body allows to achieve an additive effect. At the same time, the toxic ability of cardiac glycosides decreases without inhibiting their inotropic effect.
About the nuances
If the doctor has prescribed a drug, before using it, you must carefully read the instructions for use. Reviews about "Panangin", the price of which is quite affordable (from 100 rubles), indicate that the tool rarely provokes undesirable effects, however it is important to comply with all established restrictions. Currently, there is no final and detailed information on the kinetics of the compounds entering the patient’s body when the medication is administered. This imposes certain restrictions and creates some risks. According to reviews, the instructions for the use of "Panangin" (the price of the drug is indicated earlier) is not difficult to follow, so you should treat your health responsibly.
When will it help?
According to reviews, in the instructions for use of “Panangin”, the manufacturer provides a description of cases in which the medication is effective that is understandable enough for a person without a special education. The manufacturer indicates that the tool is intended to correct the lack of magnesium, potassium in the human body. It is taken with cardiac ischemia as an additional element of the therapeutic course. Shown "Panangin" in acute heart attack.
The instructions for the use of "Panangin" indicate that the tool helps with a chronic form of heart failure. You can take the composition for violations of the rhythm of the heartbeat. Panangin helps to correct various arrhythmic conditions, including those triggered by an excess of heart glycosides.
Is it possible or not?
Before taking the drug, it is important to consult a doctor, to find out the reviews of cardiologists about Panangin. Instructions for use, the price of non-compliance with which is an increased likelihood of side effects, indicates that the product has certain contraindications. Prescribing the drug to the client, the doctor will necessarily take into account all these nuances, but self-prescribing funds for yourself can lead to health problems.
Among the absolute contraindications is hypersensitivity to the components contained in the tool. This applies not only to the basic compounds, but also auxiliary substances. Also in the instructions for use of “Panangin” the impossibility of using tablets for chronic or acute kidney failure, atrioventricular blockade and Addison’s disease, with cardiogenic shock is indicated. You can not take the medication if there is an excess of potassium or magnesium in the body, while carrying the baby and breastfeeding. "Panangin" is prohibited until reaching the age of majority, since the effectiveness and safety of the use of the medication by this group of patients have not been established. You can not use the composition for dehydration and insufficiency of the adrenal cortex.
You can, but carefully!
There are a number of conditions in which there is an increased likelihood of side effects, which are noted by reviews and instructions for the use of “Panangina Forte” (the price of the drug is from 300 rubles), “Panangina” (the price of the drug is from 100 rubles). These include the first degree of atrioventricular block and significant impairment of renal function, acidosis, an increased likelihood of swelling.
In the presence of renal impairment, it is especially important to carefully use the product if it is not possible to regularly check the plasma content of magnesium components. There is a risk of a cumulative effect and magnesium reaching concentrations in which the electrolyte becomes toxic to humans. In the instructions for use of “Panangina Forte”, “Panangina”, the manufacturer indicates the need for careful use of the composition with cardiogenic shock, if systolic pressure is less than 90 units, with diathesis due to metabolic processes involving calcium, magnesium, ammonium phosphate. Also, special attention is required by patients who have hypophosphatemia.
Side effects
As follows from the instructions for the use of "Panangin", the price of incorrect and incorrect use of the drug is an increased likelihood of a negative response from the body. Among other cases, the most common ailments associated with improper administration of the solution. If the procedure goes too fast, there is a risk of a sharp increase in the concentration of potassium in the body in excess of normal values ​​with manifesting effects in the form of increased fatigue, confusion and a disturbance in the rhythm of the heartbeat. There is a danger of myasthenia gravis, paresthesia. Too fast administration of the solution can cause cardiac arrest. Improper use of "Panangin" can cause heart block, arrhythmia, bradycardia.
Incorrect and incorrect use of Panangin can provoke an increased content of magnesium in the body. In the instructions for use of “Panangin”, the manufacturer indicates that such a condition indicates vomiting and lethargic state, weakening of neuromuscular activity, lowering pressure. There are known cases of phlebitis, heart block, a paradoxical response of the body, in which the number of extrasystoles increases significantly.
Many or few?
Due to the instructions for use and the price of "Panangin", which is understandable to the layman, due to which the product is available to the general public, the drug is very popular. Significant experience has been gained in its use by different groups of patients, while cases of overdose have not been recorded. It is known that excessive use of the composition can cause symptoms of accumulation in the body of potassium, magnesium.
It is possible to suspect that “Panangin” was used in excessive quantities, if the patient quickly gets tired, the consciousness gets confused, and the work of the heart is disturbed. An overdose may indicate paresthesia, myasthenia gravis.
If the use of "Panangin" provoked an excess of magnesium in the body, nervous and muscle excitability are suppressed, the patient vomits, lowers blood pressure, lethargy is possible. With a sharp increase in the concentration of magnesium ions in the circulatory system, there is a risk of paralysis of the respiratory system, inhibition of reflexes of tendons and coma.
What to do?
The manufacturer in the instructions indicates the need for an urgent termination of the use of the drug if the above symptoms of excess magnesium, potassium appear. Under the supervision of a doctor, a course of symptomatic therapy is necessary. As a rule, calcium chloride is injected into a vein - 100 g per minute. If the condition is quite serious, blood dialysis is indicated.
Is it possible to replace with something: Panangin analogues
The instructions for use indicate that the main components of the drug are magnesium, potassium asparaginates. Medicines are based on the same compounds:
There is “Potassium and Magnesium Asparaginate” for sale. It is important not only to study the instructions for use for Panangin and its analogues, choosing an alternative composition prescribed to the doctor, but also consult with a specialist. Unauthorized substitution of the drug can cause a negative response of the body or insufficiently effective course.
How to use correctly?
According to the instructions, "Panangin" in the form of a solution can be used strictly for injection into a vein. One or two ampoules (no more) are diluted in 50-100 ml of a five percent glucose solution. The procedure for introducing into a vein - drops, at a speed of not more than 20 per minute. If there is a need to repeat the event, you can again use the “Panangin” after an average of five hours (deviation up and down is an hour).
The accompanying tablets "Panangin" instructions for use by the method of use indicate the following: the drug must be used orally after a meal, two capsules at a time. Frequency of use - three times daily. As a preventative measure and to maintain the patient’s condition, “Panangin” is used one tablet three times a day. The duration of the course reaches four weeks. Repeatability is possible if the patient's condition requires it.
Mutual influence
Tests have shown that Panangin is able to activate the bathotropic, dromotropic effect of drugs designed to combat arrhythmia. If hypokalemia occurs during the use of glucocorticoids, the described drug helps to correct the patient's condition. Since the medicine contains magnesium, when it is simultaneously ingested with neomycin, tetracycline, streptomycin and polymyxin B, their effectiveness is reduced. The likelihood of an increased potassium content in the body grows against the background of a combination of the drug in question and diuretics with the effect of preserving potassium, ACE inhibitors and heparin, cyclosporine.
Using both Panangin and anesthetics, you need to remember to increase the inhibitory effect of magnesium on the central nervous system. There is a risk of neural, muscle blockade due to muscle relaxants. If the patient is forced to use calcitriol and Panangin, it is necessary to control the magnesium content in the blood, since the concentration of this electrolyte can rise significantly above normal. Under the influence of calcium preparations, the effectiveness of magnesium is reduced.
The manufacturer in the accompanying documentation for the drug in any form of release indicates that Panangin in clinical trials showed compatibility with cardiac glycosides in the form of solutions. With this combination therapy, the risk of side effects is reduced, glycoside tolerance is improved.
Important Nuances
Using "Panangin", it should be remembered that too rapid injection of a solution into a vein can cause reddening of the skin.
If the patient has pathological conditions in which the potassium content in the blood is increased, Panangin is used as carefully as possible, regularly checking blood plasma for electrolyte concentration.