Reaferon-Lipint is an antiviral drug that was created on the basis of interferon. The composition of this drug includes dried recombinant alpha-2-beta human interferon. The medication, like other medicines, which also include this compound, helps to strengthen the person’s own immunity. The use of these drugs is carried out for various infectious lesions, when their own health is weakened. For example, during immunotherapy, with systemic diseases.
Reaferon-Lipint is used:
- During prophylaxis during an acute respiratory viral infection epidemic.
- In the case of systemic ailments, such as atopic dermatitis, asthma, etc.
- With viral hepatitis B - both in acute and in chronic form.
Reaferon-EU-Lipint is available in powder form. Distilled or boiled water is added to the bottle immediately before use , and then everything is shaken vigorously. According to the instructions, this drug is recommended to be taken half an hour before a meal. However, the physician is obliged to detail his own scheme of use specifically for each patient. As a rule, the general course of treatment is no more than one month.
Existing forms of release, price
- Lyophilized powder 500,000 IU / ml (for oral administration) - the price is about 700 rubles.
- For the preparation of the suspension, the powder is lyophilized 1,000,000 IU (for oral administration) - the price is about 1000 rubles.
- To prepare the suspension, lyophilized powder 250,000 IU (for oral administration) - the price is about 410 rubles.
Reaferon-Lipint: analogues
This drug has the following analogues:
- Infagel
- "Viferon ointment."
- Viferon.
Indications for use
The lyophilized powder of 1,000,000 IU and 250,000 IU for internal use is recommended for use in the following cases:
- Treatment and prevention of acute viral respiratory infection and influenza.
- Multiple sclerosis.
- Kaposi's sarcoma related to AIDS.
- Reticulosarcoma.
- Mushroom mycosis.
- Kidney cancer
- Multiple myeloma
- Transitional form of chronic granulocytic leukemia and myelofibrosis.
- Primary and secondary thrombocytosis.
- Active viral hepatitis C.
- Myeloid leukemia in a chronic form.
- Hairy cell leukemia.
The lyophilized powder of 500,000 IU / ml Reaferon-Lipint in the form of an ointment is used for viral damage to the mucous membranes and skin integuments of various localization.
In the form of a suppository, this drug in complex therapy is used for such ailments as:
- Infectious and inflammatory childhood diseases, including in premature and newborn babies.
- Meningitis.
- Sepsis.
- Influenza, SARS, including complications of a bacterial infection.
- Chlamydial, viral and bacterial pneumonia.
- Intrauterine infection - enterovirus infection, CMV infection, herpes, chlamydia, candidiasis, including visceral mycoplasmosis.
- Chronic viral hepatitis B, C, D in adults and children, including the combination of hemosorption and plasmapheresis of chronic viral hepatitis with cirrhosis and a pronounced degree of activity.
As an interferon-correcting agent Reaferon-Lipint (price is given above) is used in case of the following diseases:
- Urogenital infection (papillomavirus infection, mycoplasmosis, vaginal recurrent candidiasis, gardnerellosis, trichomoniasis, ureaplasmosis, bacterial vaginosis, CMV infection, chlamydia).
- Recurrent or primary infection of the mucous membranes and skin.
- Influenza and other acute respiratory infections and acute respiratory infections, including those complicated by bacterial infection in adults.
Contraindications
The drug "Reaferon-Lipint" (the price depends on the form of release) has the following contraindications:
- Impaired kidney, liver, or circulatory function.
- Hypersensitivity.
- Chronic hepatitis in patients who received immunosuppressant therapy shortly before (short-term pre-treatment with steroids is an exception).
- Myocardial infarction.
- Chronic hepatitis caused by decompensated liver cirrhosis.
- Severe heart disease (including a medical history).
- Epilepsy or other disorders of the central nervous system.
In addition, Reaferon-Lipint (see drug reviews below) has some limitations for use:
- High sensitivity to the components of this drug.
- Lactation.
- Pregnancy.
Side effects
Lyophilized powder for oral administration of 1,000,000 IU and 250,000 IU Reaferon-EU-Lipint (the price depends on the form of release) has the following side effects:
- Skin allergic reactions (for example, itching or rash).
- Sleep disturbance.
- Nervousness.
- Impaired consciousness.
- Drowsiness.
- Depression.
- Ischemic retinopathy.
- Vision disorder.
- Dizziness.
- Hepatitis.
- Impaired liver function.
- Heartburn.
- Increased peristalsis.
- Flatulence.
- Constipation
- Stomach ache.
- Chills and fever
- Diarrhea.
- Weight loss.
- Dry mouth.
- Change in taste.
- Vomiting and nausea.
- Sweating.
- Joint pain.
- Headache or muscle pain.
- Poor appetite.
- Lethargy.
Reaferon-Lipint for children, lyophilized powder 500 000 IU / ml:
- Ointment - no side effects are noted.
- Suppositories - allergic reactions are rarely manifested (for example, itching or rash).
Interaction
Interferon alpha reduces the activity of P-450 cytochromes, which affects the metabolism of warfarin, propranolol, diazepam, theophylline, chimes, phenytoin, cimetidine and some cytostatics. And it can also increase the cardiotoxic, neurotoxic or myelotoxic effect of drugs that started to be taken simultaneously with it or earlier.
In addition, it is necessary to avoid co-administration of Reaferon-EU-Lipint (the price is given above) with drugs that contribute to CNS depression, as well as immunosuppressive drugs (including parenteral and oral forms of corticosteroids).
It is strictly forbidden to take alcohol during treatment.
Possible doses
The drug is taken half an hour before ingestion. For the prevention of acute respiratory viral infections and influenza - 1 capsule (500,000 IU) per day, during the month 2 times a week. In the treatment of acute respiratory viral infections and influenza - 1 capsule (500,000 IU) daily for 5 days 2 times a day. If swallowing is difficult, it is allowed to carefully open the capsule and take the contents with a small amount of water.
Dosage and administration
This medication is administered orally. Before its direct application, chilled boiled or distilled water (1-2 ml) is added to the contents of the vial. As a result of shaking for about 1-5 minutes, a homogeneous mass should appear.
1. In case of acute hepatitis, the drug is taken 30 minutes before eating food according to the following scheme:
- Children from 3 to 7 years - the drug is taken 10 days 1 time per day for 500,000 IU. After biochemical control blood tests, Reaferon-Lipint for children (the price depends on the form of release) is used for a longer time - until the full clinical recovery.
- Children over 7 years old and adults - 10 days 2 times a day for 1,000,000 IU.
2. In the case of chronic hepatitis B in replicative forms (active or inactive), including chronic hepatitis B associated with glomerulonephritis, this drug must be taken 30 minutes before meals according to the following scheme:
- Children from 3 to 7 years old should take this drug 10 days 2 times a day for 500,000 IU, then for 1 month 1 time per day (preferably at night) every other day for 500,000 IU.
- Children over 7 years old and adults - 10 days 2 times a day for 1,000,000 IU, after which for 1 month 1 time per day (at night) every other day.
3. In the case of specific therapy "Reaferon-Lipint" (reviews below) must be used 30 minutes after a meal in the morning according to the following scheme:
- In the case of atopic bronchial asthma for adults - for 10 days daily at 500,000 IU. Then, for 20 days every other day, 500,000 IU. The total duration is 30 days.
- In case of allergic rhinoconjunctivitis - for 10 days daily at 500,000 IU.
4. For the purpose of prevention and treatment of acute respiratory infections and influenza, this drug is taken half an hour before a meal. "Reaferon-Lipint", the instructions for use confirm this, you need to drink as follows:
- In the treatment of acute respiratory infections and influenza - for 3 days daily 2 times a day for 500,000 IU.
- In order to prevent acute respiratory infections or influenza - when the incidence rate rises, the drug is taken for 1 month 2 times a week once a day for 500,000 IU.
Overdose
There were no cases of exceeding the dosage of this drug. Only an increase in dose-dependent side effects is possible. In case of overdose, symptomatic treatment is provided.
Related Names
"Eberon Alpha R", "Reaferon-EU-Lipint" for children, "Realdiron", "Alpharona", "Liferon", "Intron-A".
Drug storage
It is advisable to store the drug out of the reach of small children, protected from sunlight. In this case, the storage temperature should not exceed 8 ° C.
Special recommendations
The drug does not affect the ability to drive potentially dangerous machinery and vehicles. If allergic reactions occur, you should immediately consult a doctor.
How to let go
Reaferon-Lipint for children (reviews below) is sold exclusively with a prescription from a doctor.
Reviews of specialists
This drug simultaneously has not only antitumor and antiviral activity, but also the ability to restore the immune system. It received its widespread use thanks to the treatment of viral hepatitis B, like other antiviral drugs, the earlier it was prescribed, the correspondingly there is more hope for an antiviral effect. 5 days after the disease, jaundice is no longer prescribed.
In addition, this drug is used in case of viral meningoencephalitis, but only in the first four days of the disease. Still "Reaferon-Lipint" is actively used for keratitis and viral conjunctivitis. Antitumor activity allows you to prescribe this drug for some types of cancer, especially for cancer of the blood. Excellent results have been obtained in the treatment of multiple sclerosis.
It was noted that some categories of patients can hardly tolerate the use of this drug: fatigue, weakness, fever, chills appear. However, despite this, the course of treatment, in most cases, must be continued.
Sometimes, during treatment, there is a sharp decrease in platelet and white blood cell counts, which requires a control blood test and medical supervision (about 2-3 times a week). Despite the side effects, as a rule, immediate withdrawal of the drug is excluded, since the decision to cancel it should be made exclusively with the specialist who prescribed Reaferon-EU-Lipint. This is due to the fact that the expected benefits are so great that the decision to cancel requires a deliberate and maximally balanced approach.
Benefits
- The basis of this drug is scientific development, which was awarded the prize of the Government of the Russian Federation.
- Compared to other drugs, Reaferon must be taken by mouth (orally). This factor is especially relevant in pediatrics.
- Liposomal interferon is perfect for emergency prophylaxis of acute respiratory viral infections and influenza when there has been contact with the virus, but there are still no symptoms of the disease or they are only barely noticeable.
- Liposomes contribute to prolonged circulation in the blood of interferon.
- "Reaferon" acts as an inducer, that is, it contributes to the production of its own interferon.
The composition of the drug includes recombinant interferon, which was developed by genetic engineering method in laboratory conditions. In other words, this drug is not a product of natural blood and it cannot contain dangerous infections.
special instructions
As mentioned earlier, in the process of taking this medication, it is necessary to avoid its combination with immunosuppressants, as well as medications that can have any effect on the central nervous system. Throughout the course, it is very important to monitor liver function and the content of formed elements in the blood. In order to mitigate the flu-like symptoms (side effects), it is advisable to prescribe paracetamol at the same time as taking this drug.