Currently, there are a huge number of infectious diseases, which it is almost impossible to cope without using antibiotics. It is desirable that the drug was able to have a negative effect on a large number of microorganisms. These include "Cefoperazone + Sulbactam." Let's get acquainted with the indications for the use of this drug in more detail.
Release form and composition
This drug is available in powder form for the preparation of a solution. It is administered intravenously or intramuscularly. The active substance is cefoperazone in an amount of 1 g.
The drug "Cefoperazone + Sulbactam" (trade name - "Sulperazone" or "Sulperacef") and belongs to the group of antibacterial drugs.
Pharmacological action of the drug
This drug refers to combination agents. The medicine "Cefoperazone" is a broad-spectrum antibiotic. It has a negative effect on most aerobic and anaerobic bacterial organisms.
Sulbactam is an irreversible beta-lactamase inhibitor. It does not allow the destruction of penicillins and cephalosporins, since when combined with them it shows synergism.
The drug “Cefoperazone + Sulbactam” has a negative effect on cells by inhibiting mucopeptide, which is an indispensable part of the walls of bacteria.
From the body, the drug is excreted in about 8 hours with urine. The half-life is about two hours. If the patient taking this medication suffers from liver diseases, then the time of elimination of the drug increases.
The OKPD code “Cefoperazone + Sulbactam” is 24.42.11.228. The drug is made in India.
Indications for use of the drug
The drug is prescribed in the presence of infectious diseases that are provoked by microorganisms sensitive to the active substance. These include:
- Pharyngitis.
- Tonsillitis.
- Bronchitis.
- Pneumonia.
- Lung abscess.
- Urinary tract infections, for example, cystitis, gonorrhea, prostatitis, vulvovaginitis.
- ENT diseases.
- Skin pathologies of an infectious nature: furunculosis, pyoderma, abscess and others.
- Infections inside the joints.
- Sepsis.
- Meningitis.
The medicine is also taken as a prevention of bacterial complications after surgery.
The drug "Cefoperazone and Sulbactam Jodas" is also indicated for peritonitis, cholecystitis, cholangitis and other intra-abdominal infections. Only a doctor should be engaged in prescribing the medicine and determining the duration of therapy and treatment regimen.
Means "Cefoperazone and Sulbactam Spencer" is also prescribed for prevention.
Who is not recommended to take the medicine
Despite the wide spectrum of action, this tool can not be taken in some conditions:
- In the presence of hypersensitivity to the components of the drug.
- During breastfeeding, “Cefoperazone + Sulbactam” is also contraindicated.
- Renal hepatic failure requires very careful use.
- In the presence of colitis in the patient’s history.
Before starting treatment with this drug, it is necessary to discuss with the doctor the presence of contraindications.
Adverse manifestations during therapy
The drug "Cefoperazone + Sulbactam", the trade name of which is "Sulperazone", during treatment can cause the manifestation of the following side effects:
- From the urinary system, the development of hematuria is possible.
- The cardiovascular system can respond by lowering blood pressure or vasculitis.
- A blood test during treatment with the drug often shows a decrease in hemoglobin, a decrease in hematocrit, thrombocytopenia, eosinophilia, leukopenia and other abnormalities.
- Decreased albumin levels.
- Bilirubin encephalopathy is possible in newborn babies with jaundice.
- From the gastrointestinal tract, digestion, vomiting, nausea, and pseudomembranous colitis are possible .
- Urticaria, maculopapular rash, and severe itching may appear on the skin.
- Laboratory studies show an increase in liver function tests.
- At the injection site, pain is possible, with intravenous administration through a catheter, phlebitis.
- Least of all there is a headache, fever, other anaphylactic reactions of the body.
If any unwanted manifestations appear, it is necessary to discuss this issue with your doctor. It may be necessary to reconsider the dosage of the drug “Cefoperazone with Sulbactam” or completely cancel it.
What to expect with an overdose of medication
If you take this drug under the strict supervision of a doctor, then you can not worry about an overdose, but with independent therapy this is often possible. If medication has received much more than is required, then neurological disorders, including seizures, are possible.
Treatment in this case is carried out in accordance with the symptoms. The most effective is hemodialysis.
Treatment regimen and dosage
If the medicine “Cefoperazone + Sulbactam” is prescribed, the instructions for use recommend that the drug be administered intravenously or intramuscularly. For adult patients, the daily dose is usually from 2 to 4 grams of active substance. This amount must be divided into two methods.
If the patient has a severe infection, the dose can be increased to 8 g, which must also be divided into two doses per day. If there are no concomitant chronic diseases, then most patients and a daily dose of 12-16 grams are tolerated without visible side effects.
The duration of therapy is determined by the doctor. For example, with gonococcal urethritis without complications, a single dose of 500 mg of the drug is administered.
In order to prevent complications after surgery, the drug is administered to the patient 1-2 g intravenously one hour before surgery. This dose can be re-entered after 12 hours. If an operation is performed with an increased risk of complications in the form of an infection, then the prophylactic administration continues for 3 days after it.
For patients who have impaired renal function, Cefoperazone + Sulbactam is prescribed in a dosage of not more than 4 g per day. If there are problems with the liver, this dose is reduced by another half.
Since the medicine can be administered intravenously and intramuscularly, there are some features in its use.
When administered intravenously as a solvent for the powder, you can use:
- 5% dextrose solution.
- Saline.
- Sterile water for injection.
When administered intravenously, the powder in one vial must be dissolved in 10 ml of a suitable solvent. It is necessary to wait for complete dissolution and enter the drug slowly, for 3-5 minutes.
If there is a drip of the drug "Cefoperazone + Sulbactam", the instructions for use recommend 1 gram of the active substance. That is, the contents of one bottle should be dissolved in 5 ml of water for injection, and then added to the infusion solution, bringing the concentration to 20-100 mg / ml. Given the amount of solution for drip, the duration of the manipulation can be from 10 to 30 minutes.
When administered intramuscularly, either water for injection or sodium chloride can be used to dissolve the powder. The ratio is usually used as follows: 2 ml of solvent is taken per 0.5 g of the drug.
Since when administering the medicine pain usually occurs at the injection site, it is recommended to add the drug “Lidocaine 2%” when preparing the solution, but only if the patient is not allergic to the medicine.
In case of any infectious disease, injections give a positive effect faster, therefore, they are prescribed “Cefoperazone + Sulbactam” in injections. Pills act much more slowly.
Use of the drug in childhood
Toddlers often suffer from infectious diseases in which antibiotics simply cannot be dispensed with. The daily dose of the main active substance of cefoperazone should be from 50 to 200 mg per kilogram of body weight of the child. It is necessary to administer the drug in equal parts, dividing into two doses.
It is advisable that the daily dose does not exceed 12 g. If the medicine is administered by jet, then a single dose should not exceed 50 mg / kg.
50-200 mg of the drug per kilogram of weight can also be administered to newborn babies, dividing it into two doses after 12 hours. Based on the long-standing practice of using this drug in children’s therapy, it can be said that doses up to 300 mg per kilogram of body weight per day were well tolerated by babies even in the presence of bacterial meningitis.
The use of the drug during pregnancy
A medicine with the active substance cefoperazone is prescribed to women in a position only in such conditions when the benefit for the expectant mother is several times higher than the potential risk for the developing baby. If you need to use the medicine during breastfeeding, the doctor will recommend for this period of time to transfer the baby to artificial nutrition.
Interaction with other drugs
The drug "Cefoperazone" in its pharmacological properties is not combined with aminoglycosides. If there is a need for therapy with these two groups of drugs, then they are prescribed in the form of a fractional injection through two separate catheters.
Co-administration of this medication with thrombolytics, antiplatelet agents and non-steroidal anti-inflammatory drugs increases the risk of bleeding.
For patients with kidney problems, taking the medicine “Cefoperazone Sulbactam” together with aminoglycosides and diuretics is fraught with the development of nephrotoxicity.
During therapy with Cefoperazone, it is undesirable to take alcohol, otherwise it may lead to the appearance of the following symptoms:
- Nausea.
- Vomiting
- Strong headache.
- Tachycardia.
- Lowering blood pressure.
- Stomach ache.
Before you begin treatment with this drug, you must inform your doctor about all the medicines that are currently being taken.
What to do if Cefoperazone is contraindicated for you? Analogs may well replace it.
Some nuances of using the drug
During treatment with this drug should be especially careful for those patients who often have allergic reactions. The risk of such an increased sensitivity is even fatal. If at least slight allergic manifestations are observed during therapy, the drug “Cefoperazone + Sulbactam” should be immediately canceled and replaced with another agent.
If the patient has a severe degree of biliary obstruction, liver disease, and kidney problems, then an individual dose adjustment is required. In the presence of renal-hepatic insufficiency, regular monitoring of the concentration of the active substance of the drug in serum is necessary. Even without control, the dose of the drug should not exceed 2 g per day.
In some patients, vitamin C deficiency developed during treatment with Cefoperazone. Most often, such a problem appeared in those who have an inadequate diet, suffer from malabsorption or have been on intravenous nutrition for a long time. In patients undergoing anticoagulant treatment, prothrombin time is constantly required to be monitored, and if necessary, vitamin K supplementation should be prescribed.
If a long course of treatment with Cefoperazone is required, then an increase in microorganisms that are not sensitive to this medication is possible. Here we need periodic monitoring of the functioning of internal organs, especially the liver, kidneys and hematopoiesis. This is especially important in the treatment of newborns, infants, as well as premature babies.
During treatment with the drug, you should refrain from driving a car and performing work that requires an increased concentration of attention.
Analogues of the drug
If we consider any drug, then we can name two groups of drugs for it: analogues and synonyms. Synonyms include drugs that have the same active substance in their composition. For the drug "Cefoperazone" these are:
- "Bakperazon".
- Sulzoncef.
- Sulmomer.
- "Sulcef."
- "Cebanex."
- "Pactoceph" and others.
If we compare the medicine “Cefoperazone”, analogues may have additional components, which in combination with the main substance have a slightly different effect. That is why the choice of such drugs should be approached responsibly and taken only as directed by a doctor.
Another group of analogues includes drugs with the same pharmacological effect. If you take the drug "Cefoperazone + Sulbactam", analogues from this group are as follows:
- Powder "Azaran" for intravenous injections.
- Axon.
- Powder for injection "Bestum".
- Wicef.
- "Claforan."
- Kefoteks.
- Capsules "Zedeks".
- "Cemidexor" (tablets).
- Cephantral and many others.
Even with the same pharmacological effect, drugs due to various active substances can have different effects on the body, so you should not choose your own medicine based on the instructions for use.
Patient Reviews
Those patients who have repeatedly resorted to the help of the drug “Cefoperazone + Sulbactam” for the treatment of infectious diseases, note its high effectiveness. Many claim that infections of the genitourinary system can be cured quickly enough and without complications.
Moms of babies leave positive reviews about the medicine “Cefoperazone”. They noticed that children tolerate the drug well even in the presence of concomitant diseases. It must be recalled that such therapy should be carried out only in a hospital, especially for newborns.
Taking any antibiotic requires increased attention to the digestive system. To maintain the balance of microflora, it is advisable to simultaneously take appropriate drugs, for example, Linex. This question can always be discussed with your doctor.