Pyridoxine hydrochloride is a vitamin of group B. Pyridoxine or vitamin B6 combines three bio compounds: pyridoxine, pyridoxamine and pyridoxal.
With a lack of vitamin A, hypo- or vitamin deficiency may occur in the body. Pyridoxine deficiency in the body quite often manifests itself in the form of dermatitis, epileptic seizures, hypofunction of the red bone marrow, growth and development is delayed and stopped. The nervous system is affected. In the blood, hemoglobin level and iron concentration decrease, anemia develops. Vitamin is ingested by eating food. They are rich in pyridoxine: walnuts, green vegetables, yeast, rice, legumes, unrefined grains of cereal plants, cereals (wheat and buckwheat), avocados, bananas, soybeans, corn, cabbage, potatoes, molasses, liver of cattle and cod, meat, oysters, fish, egg yolk, heart, kidneys. Vitamin B6 is also synthesized by the microflora of the gastrointestinal tract.
Pyridoxine hydrochloride in the human body is phosphorylated and forms pyridoxal phosphate. The specified coenzyme is involved in the processes of lipid and protein metabolism. The portion of the vitamin that is coupled to the proteins is absorbed by the mucous membrane of the digestive tract after enzymatic hydrolysis of the proteins. With the flow of blood, the vitamin enters the liver, and then into other organs. As a result of the phosphorylation of pyridoxine, the hydrochloride forms phosphates of pyridoxal, pyridoxamine and pyridoxol. Every day, 2-3% of the vitamin supply is updated in the human body. Vitamin is excreted from the body mainly with urine. The main metabolites of pyridoxine in the urine are 4-pyridoxyl acid, which is about 20–40%.
As a coenzyme, it is part of many enzymes (racemase class) that are involved in the exchange of tyrosine and tryptophan, etc. Pyridoxal-5-phosphate is involved in the creation of the tertiary structure of phosphorylase. Vitamin B6 improves the body's absorption of polyunsaturated fatty acids and prevents the development of fatty infiltration. It delays the accumulation of cholesterol, as well as lipids and calcium on the walls of blood vessels, thereby pyridoxine prevents the development of atherosclerosis. B6 preparations normalize the functioning of the liver, digestive glands, increase the absorption of food nutrients, optimize the work of the spleen, lymph nodes and blood-forming organs, and increase the immunological resistance of the body.
Pyridoxine hydrochloride eliminates the adverse effects of antidepressants, enhances the effect of taking diuretics, it can not be mixed with a solution of vitamins B1 and B12 in the same syringe. During the use of hormonal contraceptives, the body's need for vitamin B6 increases significantly.
Pyridoxine hydrochloride instructions for use. Indications for use of the drug are food (alimentary) or secondary pyridoxine deficiency in the body, toxicosis of pregnant women, postencephalitis parkisonism, pellagra, convulsive syndrome in newborns, gastric ulcer or duodenal ulcer, peripheral uneven system diseases, hypochromic macrocytic anemia, system, which is characterized by motor excitement, as well as paresis and paralysis), hepatitis, dermatitis, exudative diathesis. The course of treatment is from one to two months. The drug can be administered parenterally (intravenously, subcutaneously, intramuscularly). When prescribing the drug, allergic side effects may occur, cases of anaphylactic shock are known. If skin reactions are observed, the drug is canceled. With caution, learcism is prescribed for liver lesions, cardiovascular diseases, and stomach ulcers.