Modern statistics of infection with parasites confirms that absolutely anyone can face this problem. Specialists report that enterobiosis is the most common type of helminthiasis. Its causative agent is a parasitic worm - pinworm. Without timely treatment of a disease of this nature, serious complications can develop that can affect the functioning of many human systems and organs.
Most often, when helminthiasis occurs, the patient is prescribed drug therapy. The most popular drug used for parasitic diseases is Nemozol. Alcohol at the same time with this tool is prohibited. Other features of the mentioned medicine, as well as instructions and patient reviews will be discussed later.
Composition, shape, packaging
Why can’t you take alcohol and Nemozol at the same time? Such a ban is associated with the active substance of the drug. It does not combine with alcohol, and when taken concurrently, it can cause a number of negative consequences.
As a main component, the antiparasitic agent under consideration contains albendazole. This medicine goes on sale in three different forms:
- White tablets, round and biconvex, coated. As excipients, Nemozol contains corn starch, purified talc, sodium lauryl sulfate, colloidal silicon dioxide, povidone-30, magnesium stearate, methyl paraben, gelatin, propyl paraben, sodium starch glycolate.
As for the film coating, it consists of hydroxypropyl methylcellulose, purified talc, titanium dioxide, sodium lauryl sulfate, methanol, polyethylene glycol-400, methylene chloride.
Nemozol tablets are packaged in blisters that are in packs of cardboard.
- White chewable tablets, oval, capsular and biconvex, with a risk on one side.
The active component of such a drug is also albendazole. The following substances are used as additional substances: citric acid, corn starch, methyl paraben, sodium lauryl sulfate, colloidal silicon dioxide, mint flavor, povidone-30, magnesium stearate, propyl paraben, pineapple flavor, gelatin, sodium starch glycolate, purified talc, aspartame.
- White suspension for oral administration. The active substance of the suspension is albendazole. Also its composition includes such auxiliary components as ice cream essence, MCC, sorbic acid, sodium carboxymethyl cellulose, purified water, glycerin, potassium hydrochloride, benzoic acid, sorbitol solution, epolisorbate-80, fruit flavor.
A drug of this form goes on sale in 20-milliliter plastic bottles, which are placed in a cardboard package with enclosed instructions for use.
Drug action
Is Nemozole and alcohol compatible? What do experts say about this? Doctors say that, as with any other anthelmintic drug, this combination is unacceptable.
What is the principle of operation of the said tool based on? The effectiveness of Nemozole is associated with the inhibitory effect of its active substance on the polymerization of beta-tubulin. This effect leads to the destruction of cytoplasmic microscopic tubules of the cells of the digestive tract of helminths. There is also a change in the biochemical processes of parasites, blocking the movements of secretory granules and other organelles in the muscle tissues of roundworms. This determines their death.
Pharmacokinetic properties
According to the instructions, the interaction of Nemozole and alcohol can lead to negative consequences.
After oral administration, the antiparasitic agent is poorly absorbed from the digestive tract. In blood plasma, the drug is not determined unchanged. Its bioavailability is quite low and amounts to approximately 30%. The simultaneous administration of a drug with fatty foods increases its absorption and the volume of maximum concentration in the blood (about 5 times).
Once inside, albendazole undergoes a rapid transformation in the liver, resulting in the formation of such a primary metabolite as albendazole sulfoxide. It also has anthelmintic activity.
The maximum concentration of albendazole sulfoxide in the blood is observed within 2-5 hours, and its connection with plasma proteins is 70%.
According to the instructions, albendazole sulfoxide is completely distributed throughout the infected body. This metabolite is found in bile, urine, liver, as well as in cystic fluid and the wall of the cyst, cerebrospinal fluid.
In the liver of albendazole, sulfoxide is converted into a secondary metabolite - albendazole sulfone and other oxidized products. Its half-life is 8-12 hours. It is excreted along with urine.
Can Nemozole be taken with alcohol?
Not all patients during the treatment of a parasitic disease can refuse their favorite habits, including drinking alcohol. But how do alcohol and Nemozol combine?
The main advantage of the drug in question (compared with other similar means) is its ability to destroy adult parasites and eggs with larvae. The wide spectrum of action of Nemozole allows it to be prescribed against many types of helminths.
As mentioned above, the active component of an antiparasitic drug is albendazole. This substance is metabolized in the liver. An overdose of the drug can cause severe functional disorders of this organ, up to the development of destructive changes. Similar effects can occur with a combination of alcohol and Nemozol. Therefore, doctors are adamant about combining treatment with antiparasitic drugs and drinking alcohol. In addition, experts report that for the duration of therapy it is imperative to exclude any liquids and products containing alcohol from your diet.
Possible consequences
According to the instructions, it is forbidden to take Nemozole and alcohol at the same time. The consequences of such a combination will not have to wait long. If the doctor's recommendations are not followed, the probability of developing negative effects increases sharply. The latter include:
- pain (acute) in the liver;
- bitter taste in the mouth (saliva);
- yellowing of the skin;
- persistent nausea, vomiting of bile.
All of these conditions indicate serious violations in the liver. By the way, the bitter taste in the mouth (saliva) indicates intoxication of the body.
Negative symptoms arising from the combination of Nemozole and alcohol (reviews of the drug are discussed below) can develop in waves (disappearing and returning).
An increase in the intensity of side effects indicates destructive processes in the liver and the likely complete dysfunction of this organ.
Ambulance
How much alcohol can I use after Nemozole? This question is asked by many people taking the drug. Experts say that any alcohol-containing drinks and products are prohibited for use for the entire period of treatment of a parasitic disease, as well as for two weeks after it. If this rule is violated and the first symptoms of intoxication appear, all necessary measures should be taken to clean the digestive tract. The best choice in this case is an enema using a weak solution of soda.
If for one reason or another the patient is contraindicated in the use of soda or enema, doctors recommend using a laxative.
Such a cleansing procedure, as an enema, allows you to save the patient's digestive tract from the remnants of the drug and its metabolites. Next, the patient must consult a specialist.
With delayed treatment of intoxication, there is a high risk of developing diseases such as:
- fatty liver disease;
- cirrhosis;
- pathology of the biliary tract;
- stones in the liver, etc.
Indications
Why is Nemozolum (in tablets) prescribed for children and adults? Instructions for use inform about the following indications:
- ascariasis;
- strongyloidosis;
- enterobiosis;
- trichinosis;
- echinococcosis;
- alveococcosis, etc.
In addition, the drug in question can be recommended for patients with a mixed form of helminthiasis. Also, it is often taken for preventive purposes.
Contraindications
In what cases should children and adults not use Nemozolum (in tablets)? Instructions for use indicate the following contraindications of the mentioned funds:
- kidney disease
- liver dysfunction;
- pathology of the biliary tract;
- peptic ulcer disease;
- hypersensitivity to drug substances.
Also, this drug is not prescribed for women during pregnancy and lactation, children under two years of age.
With extreme caution, Nemozole is used for impaired liver function and hematopoiesis.
The drug against parasites "Nemozol": instructions for use
For prevention for adults and children, this tool can only be used after consulting a specialist.
The average therapeutic dose of this drug in the treatment of nematodoses is 400 mg (by mouth, once). The medication is taken with food.
In case of a parasitic disease, Nemozol therapy should be administered simultaneously to all family members.
With echinococcosis and neurocysticercosis, people up to 60 kg and above are prescribed 400 mg 2 r / d. With a body weight of less than 60 kg, the dosage is set at the rate of 15 mg / kg per day (in 2 doses).
The highest daily dose of the drug is 800 mg.
The therapeutic course for neurocysticercosis is 10-30 days, and for echinococcosis - three cycles of 4 weeks with a two-week interval.
Side effects
In some cases, the drug "Nemozol" can cause the following side effects:
- Leukopenia, impaired liver function, dizziness, pain in the abdomen, reversible alopecia, nausea, skin rash, vomiting.
- Itching, granulocytopenia, meningeal symptoms, agranulocytosis, headache, thrombocytopenia, increased blood pressure, pancytopenia.
- Acute renal failure, fever, allergic reactions.
Patient reviews about the drug
"Nemozol" is a fairly popular anthelmintic drug, so there are a lot of reviews about it. The ratio of positive and negative messages about this tool is 50/50. Some patients claim that such a medicine is not only affordable and effective, but also quite safe, since it rarely causes side effects. However, there are also people who were dissatisfied with the results of treatment. They claim that this drug had no effect on their parasitic disease.
Another disadvantage of this medication is the impossibility of parallel use of alcohol. In some cases, this combination causes severe intoxication of the body.