Pathologies of the heart and blood vessels today firmly occupy a leading position in the list of diseases of the twenty-first century. These diseases are often fatal. Coronary heart disease with various forms of heart failure and myocardial disturbances occur in every third inhabitant of the planet. In the event that these pathologies are ignored, the patient’s well-being will only worsen, which will eventually result in a stroke or other serious illnesses.
The main objective of therapeutic therapy for patients with heart problems is to reduce the myocardial oxygen demand, and, in addition, to increase tolerance to physical and mental stress. One of the drugs prescribed for patients with ischemia, angina pectoris, and other similar diseases is a medicine called Cardionate. Instructions for use for it will be presented below. This drug is part of complex therapy, can reduce the negative manifestations and symptoms of the main diagnoses.
Pharmacological properties
The drug acts as a synthetic analogue of butyrobetaine. According to the pharmacological effects, this tool belongs to the enhancers of the tissue metabolic process.
Cardionate is able to improve energy metabolism, preventing the accumulation of long chain fatty acids in cells. This medication reduces the production of carnitine. As part of a systematic administration, this medicine improves oxygen transport and at the same time reduces the need for myocardium in oxygen molecules.
In patients with different forms of heart failure, as well as those who have ischemic myocardial damage, this drug produces the following therapeutic effect:
- Shortening the recovery period after acute myocardial damage.
- Slowing the development of necrosis. In this case, the medicine reduces the area of the necrotic area.
- Elimination of mental and physical stress due to restoration of oxygen balance in organs and tissues.
- Improving stamina and human performance.
- Increased tissue immunity.
- The provision of cardioprotective action.
"Cardionate" is effective in the presence of metabolic disorders in the tissues, in connection with this, its use helps people with pathologies of dystrophic fundus.
The composition and form of release of the drug
According to the instructions for use with Cardionate, its active substance is meldonium in the form of dihydrate. This medicine is released in the form of an injection solution, which is poured into ampoules from medical glass. Each pack contains five or ten ampoules. 1 ml of solution contains 80.2 milliliters of meldonium. For internal use, you can use "Cardionate" capsules, which are delivered in twenty or forty pieces per pack.
So, then we will consider in which diseases the drug may be useful for patients.
Indications for its use
According to the instructions for use, Cardionate has an extensive complex effect. Influencing the body, it restores the functioning of the nervous system, and also improves the functioning of the heart, blood vessels, increases the general tone.
The presented drug is used as a kind of stimulant, which allows you to increase the working capacity and stamina of a person. These properties explain the list of indications for the use of "Cardionate". Indications for use of this drug include the following diseases and conditions:
- The presence of increased loads on the body, which require enhanced energy synthesis. Thus, its use is advisable when playing sports, and, in addition, when participating in various competitions, competitions and the like.
- The presence of weakness and reduced performance.
- The presence of impaired blood circulation in the spinal cord and brain.
- The development of retinal thrombosis, especially the central veins and their branches.
- The presence of withdrawal symptoms in people who suffer from a chronic form of alcoholism.
- The period after surgery. In this case, the drug helps to accelerate recovery processes.
- The presence of ischemic damage to the heart muscles and brain.
- The presence of various forms of heart failure.
- The presence of retinopathy, which is a lesion of the eyeball without an inflammatory focus, including the hypertensive and diabetic forms of this disease.
- Blood circulation in the retina.
- Presence of retinal hemorrhage.
Dosage and administration
The final dosage of "Cardionate" should be calculated by the attending physician. In this case, the specialist proceeds from factors that can affect the risks of adverse reactions or the level of absorption of the active substance. The age of the patient, the main, and at the same time concomitant diagnoses, lifestyle and so on are taken into account.
Cardionate
The drug is administered intravenously, that is, Cardionate can be administered intramuscularly. The exception is pathology of the retina and fundus. A single dose in most cases is 500 milliliters. It is in this quantity that Cardionate is used to treat the following diseases:
- As part of the treatment of alcohol dependence, the drug is administered twice a day.
- In order to treat vascular disease and heart disease, the drug is administered once a day. If necessary, the dose can be increased to two ampoules.
- For the treatment of circulatory disorders in the spinal cord and brain, the drug is administered once a day.
- In the presence of chronic circulatory disorders in the brain space, the drug is administered once a day.
Against the background of chronic fatigue, as well as in the presence of high loads or reduced working capacity, “Cardionate” is used in high dosages, namely, two ampoules are administered once a day. Duration of use is from seven to fourteen days.
In the presence of dystrophic changes in the retina of the eye, and, in addition, in case of vascular diseases of the fundus, Cardionate is administered retrobulbarly (that is, for the eyeball) in a dosage of 0.5 milliliters. The duration of treatment is usually ten days.
This is confirmed by the instructions for use for "Cardionate".
How does the drug interact with other drugs?
The use of the drug can enhance the pharmacological effect of certain drug groups, for example, cardiac glycosides, antihypertensive drugs, and coronary dilating drugs.
In some cases, the simultaneous use of "Cardionate" with other medicines can cause a moderate increase in heart rate along with a decrease in blood pressure. In this regard, people suffering from heart disease should undergo combination therapy only after consultation with a cardiologist. Increased caution requires taking tablets "Cardionate" in combination with the following pharmacological categories and drugs:
- Medications designed to lower blood pressure.
- Peripheral vasodilators .
- Adrenergic blockers, as well as drugs in the form of "Nifedipine" and "Nitroglycerin."
Now we find out in which cases the drug is not suitable for patients to use.
Contraindications
"Cardionate" is the drug of choice for the treatment of pathologies of metabolism in tissues. It is often prescribed for the treatment of conditions that require enhanced energy metabolism. The fact is that "Cardionate" practically does not have any contraindications for use.
In addition to the individual patient intolerance to meldonium, the reasons for refusing to use this drug can only be intracranial formations, which are accompanied by an increase in pressure, as well as impaired outflow of venous blood.
"Cardionate" during pregnancy
At the time of treatment with Cardionate, breast-feeding of the baby must be stopped. As for the safety of the medicine in relation to the effect on the fetus, it has not been proven. In this regard, during pregnancy, treatment with the use of the drug is contraindicated.
Side effects
Negative reactions with the use of "Cardionate" can be extremely rare, but unfortunately they cannot be completely excluded. The manufacturer warns consumers about the following adverse reactions that may occur during the treatment period: pressure surges can occur along with dyspepsia, allergies, neurosis and tachycardia.
The severity, and at the same time the danger of adverse reactions, should be evaluated by the doctor. If necessary, the doctor makes a decision to cancel the drug or to correct the scheme of its administration and dosing.
Shelf life of the drug
Preparations that are developed on the basis of meldonium, including tablets and injections "Cardionate", must be stored at a temperature of up to twenty-five degrees in a place that is closed from sunlight. Shelf life is two years from the date of manufacture.
Cost
“Cardionate” refers to the group of the middle price segment. Its average price in Russia is:
- The price of capsules ranges from one hundred eighty to two hundred rubles.
- The cost of the injection solution is about two hundred and fifty rubles.
Analogs of "Cardionate"
In the event that, for any reason, the use of Cardionate is contraindicated for the patient, you can change it to a similar drug with the same active component. So, the analogues of "Cardionate" are:
- The drug "Meldonium", the cost of which is one hundred and fifty rubles.
- The medicine "Mildronate", which will cost three hundred and seventy rubles.
- Means "Idrinol", the price of which is 200 rubles.
- The drug "Meldonium Organics" with a cost of one hundred and seventy rubles.
Indications for use of Mildronate (for all dosage forms of the drug):
- IHD (in combination with other drugs and treatment methods);
- peripheral artery disease ;
- reduced performance;
- encephalopathy;
- physical overload (including in sports);
- postoperative period (to accelerate the recovery of the body);
- chronic heart failure;
- cardialgia (pain in the left side of the chest), caused by dishormonal myocardiopathy;
- bronchial asthma;
- COPD
- alcohol withdrawal (as an addition to specific therapy);
- stroke.
It is worth noting that in no case can you decide on a drug replacement on your own, since a dose adjustment may be required, which should be done taking into account the individual characteristics of the patient and the course of the underlying disease.
Next, we find out that people write about this drug in their reviews.
Reviews about "Cardionate"
In their reviews of this drug, people write that Cardionate is actually effective. Patients who underwent therapy with this medicine write that they have increased performance, improved mental and emotional state, and, in addition, the work of the heart muscle normalized and the nervous system stabilized.
Another interesting property of the drug is that it enhances immunity. Patients who took Cardionate during an exacerbation of infectious diseases note that their immune system has become much stronger. Many managed to avoid respiratory diseases. Also, patients write in reviews about “Cardionate” that due to the effectiveness and efficiency of this drug, doctors prescribe it quite often.
Thus, based on the reviews, it can be said that this medicine has high efficiency, with a minimum of side effects and contraindications. In their comments, people say that it is well tolerated. Satisfies consumers and the price of this drug, which in the conditions of financial instability also plays a big role.